公开(公告)号：EP1893569A4

公开(公告)日：2009-08-05

申请号：EP06784776

申请日：2006-06-12

Applicant: ELIXIR PHARMACEUTICALS INC

Inventor： SAUNDERS JEFFREY O ,  COULTER THOMAS ,  MORTENSON PAUL ,  NAVIA MANUEL A ,  PONS JEAN-FRANCOIS

IPC: C07D201/08 ,  A61K31/40 ,  A61K31/44 ,  C07D207/12 ,  C07D207/14 ,  C07D211/18

CPC classification number: C07D249/08 ,  C07D271/06 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04

公开(公告)号：EP1858842A1

公开(公告)日：2007-11-28

申请号：EP06738305.9

申请日：2006-03-15

Applicant: INVISTA Technologies S.à.r.l.

Inventor： ALLGEIER, Alan, M. ,  OSTERMAIER, John, ,  J.SENGUPTA, Sourav, K.

IPC: C07D201/08 ,  C07D223/10

CPC classification number: C07D223/10

Abstract: The invention relates to the field of production of lactams from aminonitriles, and in particular to the production of ϵ-caprolactam by the vapor phase hydrolytic cyclization of 6-aminocapronitrile. A crude liquid caprolactam comprising ϵ-caprolactam (CL), 6-aminocapronitrile (ACN) and water obtained from a vapor phase cyclization reaction of ACN is contacted with hydrogen in the presence of a hydrogenation catalyst to convert the ACN in the crude liquid caprolactam to a product comprising hexamethylenediamine (HMD) and hexamethyleneimine (HMI). Tetrahydroazepine (THA) in the crude liquid caprolactam is converted to HMI during this hydrogenation. The HMD and HMI have lower boiling points compared to ACN and thus they are more easily separated from CL in the subsequent distillation operations. Thus a process to make CL from ACN with fewer distillation stages, and with lower pressure drop and lower base temperature, is accomplished.

公开(公告)号：EP1838668A1

公开(公告)日：2007-10-03

申请号：EP05854931.2

申请日：2005-12-21

Applicant: INVISTA Technologies S.à.r.l.

Inventor： POLIAKOFF, Martyn ,  HAMLEY, Paul ,  CEPEDA, Eduardo Garcia-verdugo ,  AIRD, Graham Robert ,  COOTE, Alexander Stuart ,  YAN, Chong ,  THOMAS, William Barry ,  PEARSON, Ian

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: A process for the manufacture of a lactam from an amino alkane nitrile and/or its hydrolysis derivatives, comprising reacting a solution comprising at least about 5% by weight amino alkane nitrile in water at a temperature of greater than or equal to about 350°C and at a pressure of greater than about 250 bar. Optionally, a dilute acid may be added as a catalyst.

公开(公告)号：EP1289949B1

公开(公告)日：2007-09-05

申请号：EP01947366.9

申请日：2001-06-13

Applicant: BASF Aktiengesellschaft

Inventor： OHLBACH, Frank ,  ANSMANN, Andreas ,  FISCHER, Rolf-Hartmuth ,  MELDER, Johann-Peter

IPC: C07D201/08

CPC classification number: C07D201/08 ,  Y02P20/52

Abstract: The invention relates to a method for the production of caprolactam from a compound of formula (I): NC-(CH2)5-CO-R where R = a carboxamido, carboxlic acid or carboxylate ester group, characterised in that a) a compound (I), or mixtures thereof are hydrogenated with hydrogen in the presence of ammonia, a catalyst (II) and optionally a fluid solvent (VI) to give a mixture (III), b) separation of catalyst (II) and hydrogen from the mixture (III) to give a mixture (IV) and c) reaction of mixture (IV), in the presence of a catalyst (V) and optionally a fluid solvent (VII), to give caprolactam.

公开(公告)号：EP1761487A1

公开(公告)日：2007-03-14

申请号：EP05759156.2

申请日：2005-06-09

Applicant: Board of Trustees of Michigan State University

Inventor： FROST, John, W.

IPC: C07D201/08

CPC classification number: C07D223/12 ,  C07D201/08

Abstract: In various embodiments, the present invention can involve a method of synthesizing α-amino-ϵ -caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ϵ-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce α-amino -ϵ­ caprolactam, deaminating to produce ϵ-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ϵ-caprolactam and then polymerizing, wherein the ϵ-­caprolactam is derived from L-lysine.

公开(公告)号：EP1444241B1

公开(公告)日：2005-10-05

申请号：EP02790337.6

申请日：2002-11-05

Applicant: SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

Inventor： DRENT, Eit ,  VAN GINKEL, Roelof ,  VAN DER MADE, Renata, Helena

IPC: C07F9/50 ,  B01J31/24 ,  C07C253/30 ,  C07D201/08 ,  C07C67/22 ,  C08G69/02 ,  C08G69/26

CPC classification number: B01J31/1895 ,  B01J23/44 ,  B01J31/24 ,  B01J31/2414 ,  B01J2231/321 ,  B01J2531/80 ,  B01J2531/824 ,  C07C2/406 ,  C07C67/38 ,  C07C253/30 ,  C07C2531/24 ,  C07C2531/28 ,  C07D201/08 ,  C07F9/5027 ,  C07C255/19 ,  C07C69/24

公开(公告)号：EP1142858B1

公开(公告)日：2005-03-09

申请号：EP99959953.3

申请日：1999-12-21

Applicant: Mitsubishi Chemical Corporation

Inventor： FUJII, Masaru Mitsubishi Chemical Corporation ,  SETOYAMA, Tohru Mitsubishi Chemical Corporation

IPC: C07C51/31 ,  C07C51/245 ,  C07C59/147 ,  C07C55/14 ,  C07D201/08 ,  B01J29/14

CPC classification number: C07D201/08 ,  B01J29/061 ,  B01J29/072 ,  B01J29/14 ,  C07C51/313 ,  Y02P20/588 ,  C07C59/147 ,  C07C55/14

Abstract: A process for producing an aliphatic aldehydic acid (e.g., adipaldehydic acid) and/or aliphatic dicarboxylic acid (e.g., adipic acid) which comprises oxidizing a cyclic ketone (e.g., cyclohexanone) with molecular oxygen in the presence of an immobilized catalyst which comprises a composite comprising a support and supported thereon at least one metallic element belonging to Groups 4 to 11 of the Periodic Table and has an acid amount of 0.06 mmol or larger per gram of the support.

公开(公告)号：EP1089972B1

公开(公告)日：2004-08-18

申请号：EP99926540.8

申请日：1999-06-24

Applicant: Rhodia Polyamide Intermediates

Inventor： BOCQUENET, Gérald ,  CHIARELLI, Henri ,  LECONTE, Philippe

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: The invention concerns a method for evaporating aminonitrile and water in conditions limiting or eliminating the formation of heavy by-products in particular amino-carboxylic acid oligomers. To avoid said inconvenience, said method for evaporating aminonitrile and water is characterised in that the water in vapour state serves as balance gas for evaporation.

公开(公告)号：EP1109781B1

公开(公告)日：2004-04-14

申请号：EP99941882.5

申请日：1999-09-01

Applicant: DSM IP Assets B.V. ,  E.I. DUPONT DE NEMOURS AND COMPANY

Inventor： PESTMAN, Robert ,  VAN LIESHOUT, Lambertus, Hubertus, Wilhelmus, M.

IPC: C07D201/08 ,  C07C227/08 ,  C07C231/14

CPC classification number: C07C227/08 ,  C07C231/14 ,  C07D201/08 ,  Y02P20/52

Abstract: Process for preparing an aqueous mixture of ε-caprolactam and 6-aminocaproic acid and or 6-aminocaproamide which involves, as the reductive amination step, contacting 5-formylvaleric acid and/or an alkyl 5-formylvalerate in water as solvent with hydrogen and an excess of ammonia in the presence of a ruthenium on carrier, as a catalyst, wherein the carrier is titanium oxide, zirconium oxide, graphite or carbon and the catalyst also contains at least one of the metals of group 8-11, or a compound of these metals. The aqueous mixture can be used to prepare ε-caprolactam.

公开(公告)号：EP1401811A1

公开(公告)日：2004-03-31

申请号：EP02754703.3

申请日：2002-06-18

Applicant: BASF AKTIENGESELLSCHAFT

Inventor： FISCHER, Rolf-Hartmuth ,  PINKOS, Rolf ,  RÖSCH, Markus ,  STEIN, Frank

IPC: C07D207/267 ,  C07D201/08

CPC classification number: C07D207/267

Abstract: The invention relates to a method for producing pyrrolidones which are optionally N-substituted by hydrogenation in the gas phase in moisture free conditions of substrates selected from C4-dicarboxylic acids and derivatives thereof, optionally by adding ammonia or primary amines, using a Cr-free catalyst with 5 - 95 wt. % of CuO, preferably 30 - 70 wt.- % of CuO, and 5 - 95 wt.- % of Al2O3, preferably 30 - 70 wt.- % of Al2O3, and O - 60 wt.- %, preferably 5 - 40 wt. % of ZnO.

Abstract translation: 本发明涉及一种生产吡咯烷酮的方法，所述吡咯烷酮任选在气相中在选自C 4 - 二羧酸及其衍生物的底物的无水条件下通过氢化进行N-取代，任选通过添加氨或伯胺，使用无Cr 催化剂与5-95wt。 的CuO，优选30-70重量％的CuO和5-95重量％的Al 2 O 3，优选30-70重量％的Al 2 O 3和0-60重量％，优选5-40重量％ 重量。 ％的ZnO。