公开(公告)号：EP2542531A1

公开(公告)日：2013-01-09

申请号：EP10846930.5

申请日：2010-07-28

申请人： Gharda, Keki Hormusji

发明人： Gharda, Keki Hormusji

IPC分类号： C07D231/44 ,  C07D231/00 ,  A01P13/00 ,  C07C211/52 ,  C07C211/00 ,  C07C209/10 ,  C07C209/00

CPC分类号： C07D231/44

摘要： A process for preparation of a trifluoromethylsulfinyl pyrazole compound of formula (I) from a compound of formula (III) is provided, wherein R, R
1 and R
2 represent a group containing halogen respectively and R
3 represents a perhaloalkyl.

摘要翻译： 提供由式（III）化合物制备式（I）的三氟甲基亚磺酰基吡唑化合物的方法，其中R，R 1和R 2分别代表含卤素的基团且R 3代表全卤代烷基。

公开(公告)号：EP1761500B1

公开(公告)日：2011-09-07

申请号：EP05756166.4

申请日：2005-06-14

申请人： Merial Limited

发明人： CHOU, David, Teh-Wei ,  KNAUF, Werner ,  MAIER, Michael ,  LOCHHAAS, Friederike ,  SCHNATTERER, Stefan ,  SEEGER, Karl

IPC分类号： C07D231/44 ,  A01N43/56 ,  C07D411/12 ,  C07D405/12

CPC分类号： C07D231/44 ,  C07D405/12 ,  C07D411/12

摘要： The invention relates to 5-(substituted dithio- or dioxy-alkylamino)pyrazole derivatives of formula (I) or salts thereof: wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).

摘要翻译： 本发明涉及式（I）的5-（取代的二硫代 - 或二氧 - 烷基氨基）吡唑衍生物或其盐：其中各种符号如说明书中所定义，涉及其制备方法，其组合物及其 用于控制害虫（包括节肢动物和蠕虫）。

公开(公告)号：EP1968578A4

公开(公告)日：2011-02-23

申请号：EP06832241

申请日：2006-12-14

申请人： MAKHTESHIM CHEM WORKS LTD

发明人： ZAMIR SHARONA

IPC分类号： C07D231/44 ,  A01N43/56

CPC分类号： C07D231/44 ,  A01N43/56 ,  A01N47/02 ,  C07B2200/13 ,  C07C15/06 ,  C07C49/203

摘要： The present invention relates to novel crystalline polymorphs, solvate pseudomorphs and amorphous form of 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (fipronil). The present invention also provides methods for preparing the novel polymorphs, pseudomorphs and amorphous form, as well as insecticidal or pesticidal compositions comprising same, and methods of use thereof as pesticidal agents.

公开(公告)号：EP1765787B1

公开(公告)日：2010-03-31

申请号：EP05750617.2

申请日：2005-06-14

申请人： Merial Limited

发明人： CHOU, David, Teh-Wei ,  KNAUF, Werner ,  MAIER, Michael ,  LOCHHAAS, Friederike ,  SEEGER, Karl

IPC分类号： C07D231/38 ,  A01N43/56 ,  C07D231/44

CPC分类号： C07D231/44 ,  C07D231/38

摘要： The invention relates to 5-(oximinoalkyl- and hydrazonalkyl-amino)pyrazole derivatives of formula (I) or salts thereof: formula (I), wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).

公开(公告)号：EP2069311A1

公开(公告)日：2009-06-17

申请号：EP06744557.7

申请日：2006-04-25

申请人： Gharda Chemicals Limited

发明人： GHARDA, Keki, Hormusji ,  MALTE, Ashokkumar, Maganlal ,  JOSEPH, Pulinattu, Cherian ,  PARKAR, Sureshkumar, Dattatraya ,  SATHE, Shekhar, Vishwanath ,  DAMANIA, Pragnesh, Dalpatram

IPC分类号： C07D231/44

CPC分类号： C07D231/44

摘要： This invention relates to a process for the preparation of 5-amino-1-phenyl-3-cyano-4-trifluoromethyl sulphinyl pyrazoles as defined by Formula- I, wherein: Rl = trif luoromethyl or trif luoromethoxy, and R2, R3 = individually hydrogen, chlorine or bromine , the process comprising the step of oxidizing a compound of Formula- II, wherein: Rl = trifluoromethyl or trif luoromethoxy, and R2, R3 = individually hydrogen, chlorine or bromine , in a medium comprising at least one oxidizing agent and trichloro acetic acid, and/or the reactions product (s) of the at least one oxidizing agent and trichloro acetic acid, and at least one melting point depressant. The preferred pyrazole is Fipronil, preferably prepared using hydrogen peroxide and dichloro acetic acid at room temperature .

公开(公告)号：EP1879869A1

公开(公告)日：2008-01-23

申请号：EP06742664.3

申请日：2006-04-25

申请人： Merial Limited

发明人： SCHNATTERER, Stefan ,  MAIER, Michael ,  LOCHHAAS, Friederike ,  KNAUF, Werner ,  SEEGER, Karl

IPC分类号： C07D231/44

CPC分类号： C07D231/44

摘要： The invention relates to a process for the preparation of 5-alkylthioethylamino-1-phenyl-pyrazoles of formula (I) and the preparation of 5-methylamino-1-phenylpyrazole intermediates.

公开(公告)号：EP1841744A1

公开(公告)日：2007-10-10

申请号：EP05819854.0

申请日：2005-12-02

申请人： Merial Limited

发明人： SCHNATTERER, Stefan ,  MAIER, Michael ,  PETRY, Friederike ,  KNAUF, Werner ,  SEEGER, Karl

IPC分类号： C07D231/44 ,  C07D401/12 ,  C07D403/12 ,  A01N43/56 ,  A01N43/60 ,  A01N43/62 ,  C07D403/04 ,  A61K31/4155 ,  A61K31/496 ,  A61K31/506 ,  A61K31/551

CPC分类号： C07D231/44

摘要： The invention relates to 5-diazacycloalkylpyrazole derivatives of the formula (I) or salts thereof a process for their preparation, to compositions thereof and to their use for the control of pests, including arthropods and helminths.

公开(公告)号：EP1814862A1

公开(公告)日：2007-08-08

申请号：EP05791711.4

申请日：2005-09-27

申请人： Merial Limited

发明人： CHOU, David, Teh-Wei ,  THÖNESSEN, Maria ,  KUHLMANN, Anke ,  DÖLLER, Uwe ,  HEMPEL, Waltraud

IPC分类号： C07D231/44 ,  C07D401/12 ,  A01N43/56

CPC分类号： C07D231/44 ,  A01N43/56 ,  C07D401/12

摘要： Disclosed are 5-(vinylamino)pyryazole derivatives of formula I or pesticidcally acceptable salts thereof (I) wherein, for example, W is =N-, =CH-, =CR6- or =C(NH2)-, R6 is halogen or haloalkyl, R1 is cyano, halogen, alkyl, haloalkyl or -CS-N H2, R2 is alkyl or cycloalkyl, R3 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, aralkyl, heterocyclylalkyl, -CO-O-R9, -CO-R10, -SO-R', -S02-R12; R9, R10, R11 and R12 are for example organic groups, R4 is halogen or -NH2, R5 is haloalkyl, haloalkoxy, halogen or -SF5, and n is an integer selected from 0, 1 or 2. These compounds cab be used for controlling pests, especially by treatment of domestic animals.

摘要翻译： 公开了式I的5-（乙烯基氨基）吡唑衍生物或其农药可接受的盐（I），其中例如W是= N-，= CH-，= CR6-或= C（NH2） - ，R6是卤素或 卤代烷基，R 1为氰基，卤素，烷基，卤代烷基或-CS-NH 2，R 2为烷基或环烷基，R 3为烷基，烯基，炔基，环烷基，芳基，杂环基，芳烷基， CO-R10，-SO-R'， - SO2-R12; R9，R10，R11和R12是例如有机基团，R4是卤素或-NH2，R5是卤代烷基，卤代烷氧基，卤素或-SF5，并且n是选自0,1或2的整数。这些化合物可用于 特别是通过治疗家畜来控制害虫。

公开(公告)号：EP1761501A1

公开(公告)日：2007-03-14

申请号：EP05757057.4

申请日：2005-06-14

申请人： Merial Ltd.

发明人： SCHNATTERER, Stefan ,  MAIER, Michael ,  LOCHHAAS, Friederike ,  KNAUF, Werner ,  SEEGER, Karl

IPC分类号： C07D231/44 ,  A01N43/56

CPC分类号： C07D231/44

摘要： The invention relates to polar 5-aminopyrazole carbamate derivatives of formula (I) or salts thereof: (I), wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).

摘要翻译： 本发明涉及式（I）的极性5-氨基吡唑氨基甲酸酯衍生物或其盐：（I），其中各种符号如说明书中所定义，涉及其制备方法，其组合物及其用于 控制害虫（包括节肢动物和蠕虫）。

公开(公告)号：EP1542996A2

公开(公告)日：2005-06-22

申请号：EP03752495.6

申请日：2003-09-17

申请人： Merck & Co., Inc.

发明人： ALI, Amjad ,  ASTER, Susan, D. ,  BALKOVEC, James, M. ,  GRAHAM, Donald, W. ,  HUNT, Julianne, A. ,  KALLASHI, Florida ,  SINCLAIR, Peter, J. ,  TATA, James, R. ,  TAYLOR, Gayle, E. ,  GOULET, Joung, L.

IPC分类号： C07D417/00 ,  C07D231/44

CPC分类号： C07J71/0047 ,  C07D231/54 ,  C07D401/12 ,  C07D403/04 ,  C07D409/12 ,  C07D413/04 ,  C07D417/04 ,  C07D491/113

摘要： The present invention encompasses compounds of Formula I: or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharmaceutical compositions and methods of use are also included.