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    AN INDUCIBLE BACULOVIRUS SYSTEM IN INSECT CELLS
    54.
    发明公开
    AN INDUCIBLE BACULOVIRUS SYSTEM IN INSECT CELLS 审中-公开
    苏格兰。。。。。。。。。。。。。。。

    公开(公告)号：EP2529021A1

    公开(公告)日：2012-12-05

    申请号：EP11701116.3

    申请日：2011-01-25

    申请人： Fitzgerald, Daniel Josef ,  Walzel, Bernd

    发明人： Fitzgerald, Daniel Josef ,  Walzel, Bernd

    IPC分类号： C12N15/866 ,  C12N15/63 ,  C12N1/21 ,  C12N5/16

    CPC分类号： C12N15/86 ,  C12N2710/14143 ,  C12N2830/005 ,  C12N2830/006

    摘要： The present invention describes a novel baculovirus protein expression system in insect cells, where the expression of recombinant protein(s) is inducible. By the inducible expression systems of the invention, expression of the recombinant protein of interest can be repressed d u ring virus amplification, and thereafter activated in the presence or absence, respectively, of an inducing molecule or by a change in environmental conditions. The novel expression system does not produce significant levels of recombinant protein by baculovirus-infected cells during virus amplification prior to induction, thereby reducing selection pressure on the expression cassette for the recombinant protein. When induction is initiated, an increased yield of recombinant protein is thus produced relative to presently available, non-inducible baculovirus expression methods. Further, it is demonstrated herein that the yield of protein expression derived from the described methodology further increases relative to non-inducible systems as the scale of protein expression increases.

    PROCESS FOR PRODUCING FINGOLIMOD SALTS
    59.
    发明公开
    PROCESS FOR PRODUCING FINGOLIMOD SALTS 审中-公开
    生产F木酸盐的方法

    公开(公告)号：EP2456752A2

    公开(公告)日：2012-05-30

    申请号：EP10737516.4

    申请日：2010-07-23

    申请人： ratiopharm GmbH

    发明人： GIDWANI, Ramesh Matioram ,  HIREMATH, Channaveerayya

    IPC分类号： C07C213/08

    CPC分类号： C07C213/08 ,  C07B2200/13 ,  C07C55/07 ,  C07C55/10 ,  C07C55/14 ,  C07C59/50 ,  C07C215/28 ,  C07C231/12 ,  C07C233/18

    摘要： The invention relates to a process for producing pharmaceutically acceptable salts of fingolimod (I), comprising the step of reacting N-[1,1-bis hydroxymethyl-3-(4-octyl phenyl)-propyl]-acylamide (II) with an acidic compound. Furthermore, the invention provides different pharmaceutically acceptable salts of fingolimod and a polymorphic form of fingolimod hydrochloride.

    摘要翻译： 本发明涉及制备芬戈莫德（I）的药学上可接受的盐的方法，其包括使N- [1,1-双羟甲基-3-（4-辛基苯基） - 丙基]酰胺（II）与 酸性化合物。 此外，本发明提供了芬戈莫德的不同药学上可接受的盐和盐酸芬戈莫德的多晶型。