公开(公告)号：EP4410423A1

公开(公告)日：2024-08-07

申请号：EP24154926.0

申请日：2024-01-31

Applicant: Academia Sinica

Inventor： CHUNG, PO-WEN ,  DU, YUAN-PENG

IPC: B01J23/755 ,  B01J35/73 ,  B01J35/45

CPC classification number: B01J23/002 ,  B01J23/755 ,  B01J2235/1520240101 ,  B01J35/45 ,  B01J35/73 ,  B01J35/77 ,  B01J2235/3020240101 ,  B01J37/18 ,  B01J35/615 ,  C07C231/12

Abstract: Disclosed are bifunctional composite catalysts which have a basic mixed oxide support derived from layer double hydroxides and methods for conversion of β-hydroxy carbonyl species and preparation of amino alcohol precursor using the same. By the bifunctional catalyst, the abundant basic sites on hydrotalcite oxide (HTO) allow retro-aldol reaction to outpace direct hydrogenation, thus achieving an exceptional selectivity towards a desired product produced through retro-aldol reaction and then hydrogenation by, for example, nickel nanoparticles on the support. Accordingly, this method exhibits particular utility in the renewable production of N-acetylethanolamine from biomass-derived N-acetyl glucosamine (GlcNAc) without using homogeneous base as a co-catalyst.

公开(公告)号：EP2215042B2

公开(公告)日：2024-06-26

申请号：EP08856599.9

申请日：2008-12-02

IPC: C07C41/03 ,  C07C43/12 ,  C07C231/12 ,  C07C303/40

CPC classification number: C07C231/12 ,  C07C41/03 ,  C07C303/40

公开(公告)号：EP3418284A1

公开(公告)日：2018-12-26

申请号：EP18182552.2

申请日：2014-07-18

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： DOCKNER, Michael ,  RODEFELD, Lars ,  HEINRICH, Jens Dieter

IPC: C07F9/50 ,  C07F15/00 ,  C07C231/12 ,  C07C233/15

CPC classification number: C07C231/12 ,  C07B37/04 ,  C07C209/68 ,  C07C233/66 ,  C07F9/5004 ,  C07F9/5022 ,  C07F9/5407 ,  C07F9/5442 ,  C07C233/15 ,  C07C211/52

Abstract: Die vorliegende Erfindung betrifft Verbindungen der Formel (V)

oder Salze hiervon.

公开(公告)号：EP3359522A1

公开(公告)日：2018-08-15

申请号：EP16853064.0

申请日：2016-09-09

Applicant: Chiral Quest (suzhou) Co., Ltd. ,  Jiangxi Long Life Bio-pharmaceutical Co., Ltd.

Inventor： WU, Shengwen ,  LI, Wenge ,  WU, Lei ,  ZOU, Li ,  HU, Siming ,  XU, Tengyue ,  LIU, Hongfeng ,  TAO, Yi ,  CHI, Yongxiang

IPC: C07C271/16 ,  C07C269/06 ,  C07C271/18 ,  C07C269/00

CPC classification number: C07C269/06 ,  C07C231/12 ,  C07C269/00 ,  C07C271/64 ,  C07C233/47 ,  C07C271/22 ,  C07C233/18

Abstract: A process is provided for preparation of (R)-N-Boc biphenyl alaninol.It provides a preparation process for a compound outlined as compound 4, which includes these operations: in one of the alcohol solvents, asymmetric hydrogenation of 5 in the presence of [Rh(Duanphos)(X)]Y and hydrogen to provide compound 4. Here "Duanphos" is (Rc,Sp)-Duanphos or (Sc,Rp)-Duanphos; X is NBD or/and COD; Y is one or more of BF4, PF6, SbF6. This process has a lot of advantages, such as low cost, safe operation, less pollution and high yield. The product was obtained in >99% purity and ee which is suitable to scale up in industrial scale.

公开(公告)号：EP1833605B1

公开(公告)日：2018-08-15

申请号：EP06733627.1

申请日：2006-01-09

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： BUCHWALD, Stephen, L. ,  ANDERSON, Kevin, W.

IPC: B01J31/24 ,  C07F9/50 ,  C07C303/22 ,  C07C41/30 ,  C07C303/40 ,  C07B37/04 ,  C07B43/04 ,  C07D409/06 ,  C07C227/16 ,  C07C231/12 ,  C07C51/353 ,  C07C51/363 ,  C07C51/367

CPC classification number: C07C51/367 ,  B01J31/2404 ,  B01J2231/4211 ,  B01J2231/4227 ,  B01J2231/4266 ,  B01J2531/0266 ,  B01J2531/824 ,  B01J2531/847 ,  B01J2531/96 ,  C07B37/04 ,  C07B43/04 ,  C07C41/30 ,  C07C51/353 ,  C07C51/363 ,  C07C227/16 ,  C07C231/12 ,  C07C303/22 ,  C07C303/40 ,  C07D409/06 ,  C07F9/5022 ,  C07C65/105 ,  C07C63/331 ,  C07C63/72 ,  C07C311/16 ,  C07C229/60 ,  C07C233/65 ,  C07C309/30 ,  C07C43/215

Abstract: One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.

公开(公告)号：EP3350160A1

公开(公告)日：2018-07-25

申请号：EP16766182.6

申请日：2016-09-01

Applicant: Eastman Chemical Company

Inventor： BOAZ, Neil, Warren ,  CLENDENNEN, Stephanie, Kay ,  ZHANG, Yuan ,  FEVOLA, Michael, James ,  FÜTTERER, Tobias, Johannes

IPC: C07C305/06 ,  C07C309/14 ,  C07C227/14 ,  C07C229/12 ,  C07C237/06 ,  C11D1/62

CPC classification number: C07C309/18 ,  B01F17/0042 ,  B01F17/0092 ,  C07C227/18 ,  C07C229/12 ,  C07C231/12 ,  C07C237/06 ,  C07C303/08 ,  C07C303/22 ,  C07C309/14 ,  C09K15/20 ,  C09K15/28 ,  C12P13/001 ,  C12P13/02 ,  C07C229/16

Abstract: Disclosed are a variety of amphoteric compounds containing a quaternary nitrogen group, a covalently bound counterion, and an ester or amide group. These amphoteric compounds can be advantageously prepared via a chemoenzymatic green process, and exhibit good surfactant properties.

公开(公告)号：EP2173702B1

公开(公告)日：2018-07-04

申请号：EP06791291.5

申请日：2006-05-10

Applicant: Studiengesellschaft Kohle mbH

Inventor： GOOSSEN, Lukas ,  DENG, Guo-Jun,

IPC: C07C201/12 ,  C07C253/30 ,  C07C255/64 ,  C07C41/30 ,  C07C25/18 ,  C07C315/04 ,  C07C317/14 ,  C07C209/68 ,  C07C49/78 ,  C07C25/24 ,  C07C49/84 ,  C07C45/72 ,  C07C45/68 ,  C07C211/55 ,  C07C233/07 ,  C07C319/20 ,  C07C205/57 ,  C07C43/205 ,  C07B37/04 ,  B01J31/26

CPC classification number: C07D333/08 ,  B01J27/122 ,  B01J27/232 ,  B01J31/1815 ,  B01J31/183 ,  B01J31/2234 ,  B01J31/2404 ,  B01J31/26 ,  B01J2231/4205 ,  B01J2531/0241 ,  B01J2531/16 ,  B01J2531/17 ,  B01J2531/824 ,  C07B37/04 ,  C07C1/26 ,  C07C17/263 ,  C07C17/2637 ,  C07C17/266 ,  C07C41/30 ,  C07C45/68 ,  C07C45/72 ,  C07C201/12 ,  C07C209/68 ,  C07C231/12 ,  C07C253/30 ,  C07C315/04 ,  C07C319/20 ,  C07C2527/122 ,  C07C2531/24 ,  C07C2531/28 ,  C07C2531/30 ,  C07C2603/26 ,  C07C15/52 ,  C07C25/18 ,  C07C25/24 ,  C07C49/782 ,  C07C47/546 ,  C07C49/84 ,  C07C317/14 ,  C07C211/55 ,  C07C233/07 ,  C07C255/64 ,  C07C323/09 ,  C07C205/06 ,  C07C205/11 ,  C07C205/35 ,  C07C205/44 ,  C07C205/45 ,  C07C205/57 ,  C07C43/205

公开(公告)号：EP2896609B1

公开(公告)日：2018-06-27

申请号：EP15152927.8

申请日：2010-07-23

Applicant: ratiopharm GmbH

Inventor： Gidwani, Ramesh Matioram ,  Hiremath, Channaveerayya

IPC: C07C215/28 ,  C07C59/265

CPC classification number: C07C213/08 ,  C07B2200/13 ,  C07C55/07 ,  C07C55/10 ,  C07C55/14 ,  C07C59/50 ,  C07C215/28 ,  C07C231/12 ,  C07C233/18

Abstract: The invention relates to the citrate salt of fingolimod in crystalline form and its use in the treatment of relapsing-remitting multiple sclerosis.

公开(公告)号：EP3166405A4

公开(公告)日：2018-06-20

申请号：EP15818808

申请日：2015-07-08

Applicant: VALENT BIOSCIENCES LLC

Inventor： WANG GARY T ,  HEIMAN DANIEL F ,  VENBURG GREGORY D ,  NAGANO EIKI ,  SURPIN MARCI ,  LUSTIG JOSEPH H

IPC: A01N37/42 ,  A01N53/00 ,  C07C67/44 ,  C07C69/738

CPC classification number: A01N37/42 ,  A01N43/78 ,  A01N53/00 ,  C07B2200/07 ,  C07C51/16 ,  C07C59/90 ,  C07C67/44 ,  C07C69/738 ,  C07C231/12 ,  C07C235/78 ,  C07C253/30 ,  C07C255/31 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/16 ,  C07D277/64 ,  H05K999/99

Abstract: The invention relates to a novel class of (S)-3′-substituted-abscisic acid derivatives and (±)-3′-substituted-abscisic acid derivatives, and methods of synthesizing the derivatives.

公开(公告)号：EP3202759A4

公开(公告)日：2018-05-09

申请号：EP15847985

申请日：2015-09-24

Applicant: MEGABIOWOOD CO LTD

Inventor： PARK KI DUK ,  LEE CHANGJOON JUSTIN ,  KIM DONG JIN ,  PAE AE NIM ,  CHOO HYUN AH ,  MIN SUN JOON ,  KANG YONG KOO ,  KIM YUN KYUNG ,  SONG HYO JUNG ,  CHOI JI WON ,  NAM MIN HO ,  HEO JUN YOUNG ,  YEON SEUL KI ,  JANG BO KO ,  JU EUN JI ,  JO SEON MI ,  PARK JONG-HYUN

IPC: A61K31/16 ,  A61K31/167 ,  C07C231/12 ,  C07C237/04 ,  C07C237/06 ,  C07C237/20 ,  C07C309/04

CPC classification number: C07C237/06 ,  A61K31/16 ,  A61K31/167 ,  C07C231/12 ,  C07C237/04 ,  C07C237/20 ,  C07C309/04

Abstract: The present disclosure relates to an ±-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.