公开(公告)号：EP4106759A1

公开(公告)日：2022-12-28

申请号：EP21705972.4

申请日：2021-02-19

申请人： AB Science

发明人： MOUSSY, Alain ,  MANSFIELD, Colin

IPC分类号： A61K31/496 ,  A61P25/28

公开(公告)号：EP4069230A1

公开(公告)日：2022-10-12

申请号：EP20816176.0

申请日：2020-12-02

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/496 ,  A61K45/06 ,  A61P11/06

公开(公告)号：EP3831384A1

公开(公告)日：2021-06-09

申请号：EP19306550.5

申请日：2019-12-02

申请人： AB Science

发明人： MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/496 ,  A61K45/06 ,  A61P11/06

摘要： The present invention relates to a 2-aminoarylthiazole derivative or a pharmaceutically acceptable salt or solvate thereof, in particular masitinib or a pharmaceutically acceptable salt or solvate thereof, for use in the treatment of asthma in a subject in need thereof, wherein the subject has an elevated level of eosinophils. In particular, the present invention relates to a 2-aminoarylthiazole derivative or a pharmaceutically acceptable salt or solvate thereof, in particular masitinib or a pharmaceutically acceptable salt or solvate thereof, for use in the treatment of asthma in a subject with an eosinophil blood count at baseline ranging from 150 cells/µL to 300 cells/µL.

公开(公告)号：EP3350176A1

公开(公告)日：2018-07-25

申请号：EP16769948.7

申请日：2016-09-16

申请人： AB Science

发明人： MOUSSY, Alain ,  BENJAHAD, Abdellah ,  PEZ, Didier ,  SCHALON, Claire ,  SANDRINELLI, Franck ,  MARTIN, Jason ,  PICOUL, Willy ,  CHEVENIER, Emmanuel

IPC分类号： C07D413/14 ,  A61K31/506 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D413/14

摘要： The present invention is concerned with substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, autoimmune, allergic, hematological, inflammatory and degenerative disorders. In particular, the compounds of the invention are Syk inhibitors. The invention also relates to a process for manufacturing the compounds of the invention.

公开(公告)号：EP3144307A1

公开(公告)日：2017-03-22

申请号：EP15185910.5

申请日：2015-09-18

申请人： AB Science

发明人： MOUSSY, Alain ,  BENJAHAD, Abdellah ,  PEZ, Didier ,  SCHALON, Claire ,  SANDRINELLI, Franck ,  MARTIN, Jason ,  PICOUL, Willy ,  CHEVENIER, Emmanuel

IPC分类号： C07D413/14 ,  A61K31/506 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D413/14

摘要： The present invention is concerned with substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, autoimmune, allergic, hematological, inflammatory and degenerative disorders. In particular, the compounds of the invention are Syk inhibitors. The invention also relates to a process for manufacturing the compounds of the invention.

摘要翻译： 本发明涉及选择性调节，调节和/或抑制由涉及各种人和动物疾病如细胞增殖，代谢，自身免疫，过敏的某些天然和/或突变蛋白激酶介导的信号转导的取代的恶唑衍生物 ，血液学，炎症和退行性疾病。 特别地，本发明的化合物是Syk抑制剂。 本发明还涉及制备本发明化合物的方法。

公开(公告)号：EP3122744A1

公开(公告)日：2017-02-01

申请号：EP15711211.1

申请日：2015-03-23

申请人： AB Science

发明人： BENJAHAD, Abdellah ,  MARTIN, Jason ,  SCHALON, Claire ,  PEZ, Didier ,  CHEVENIER, Emmanuel ,  SANDRINELLI, Franck ,  PICOUL, Willy ,  MOUSSY, Alain

IPC分类号： C07D413/14 ,  C07D417/14 ,  A61K31/499 ,  A61P35/00

CPC分类号： C07D413/14 ,  A61K31/506 ,  A61K31/5377 ,  C07D417/14

摘要： The present invention is concerned with substituted oxazole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, autoimmune, allergic, and degenerative disorders. In particular, the presently disclosed compounds are Syk inhibitors.

摘要翻译： 本发明涉及选择性调节，调节和/或抑制由涉及各种人和动物疾病如细胞增殖，代谢，自身免疫的某些天然和/或突变蛋白激酶介导的信号转导的二氮杂螺环烷酮取代的恶唑衍生物 ，过敏性和退行性疾病。 特别地，目前公开的化合物是Syk抑制剂。

公开(公告)号：EP3052103A1

公开(公告)日：2016-08-10

申请号：EP14780847.1

申请日：2014-10-03

申请人： AB Science ,  ACOBIOM

发明人： PIQUEMAL, David ,  MOUSSY, Alain ,  KINET, Jean-Pierre

IPC分类号： A61K31/496 ,  A61K31/7068 ,  C12Q1/68 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  C12Q1/68 ,  C12Q1/686 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention relates to an in vitro method for determining the prognosis of pancreatic cancer in a patient. More particularly, this method comprises the following steps: a) measuring the expression level of at least one gene chosen in the group consisting in: ACOX-1, TNFRSF10B, LYN, HIF1A, UBE2H, PARP2, ABCC1, ABCC3, IGJ and RPS23 or homologous genes, in a blood sample of said patient, b) predicting the outcome of the pancreatic cancer in said patient. The invention also relates to a kit specifically designed to carry out such a method.

公开(公告)号：EP3010906A1

公开(公告)日：2016-04-27

申请号：EP14732550.0

申请日：2014-06-20

申请人： AB Science

发明人： MOUSSY, Alain ,  BENJAHAD, Abdellah ,  SCHALON, Claire ,  PEZ, Didier ,  CHEVENIER, Emmanuel ,  SANDRINELLI, Franck ,  MARTIN, Jason ,  PICOUL, Willy

IPC分类号： C07D401/14 ,  C07D413/14 ,  A61K31/427 ,  A61K31/4406 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  C07D417/12 ,  C07D417/14 ,  A61P35/00 ,  A61P37/00 ,  A61P17/00 ,  A61P29/00 ,  A61P25/00

CPC分类号： C07D417/14 ,  A61K8/49 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  A61Q19/00 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12

摘要： Disclosed are compounds of formula I or pharmaceutically acceptable salts thereof: Wherein n, R1, R2, R3, R4, R5, A, Q and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.

摘要翻译： 公开了式I化合物或其药学上可接受的盐：其中n，R1，R2，R3，R4，R5，A，Q和X如说明书中所定义。 这些化合物选择性调节，调节和/或抑制由涉及各种人和动物疾病如细胞增殖，代谢，过敏和退行性疾病的某些天然和/或突变蛋白激酶介导的信号转导。 更具体地说，这些化合物是有效和选择性的天然和/或突变c-kit抑制剂。

公开(公告)号：EP1874305B1

公开(公告)日：2014-08-27

申请号：EP06755876.7

申请日：2006-04-04

申请人： AB Science ,  Centre National de la Recherche Scientifique ,  Institut Curie

发明人： GRIERSON, David ,  BENJAHAD, Abdellah ,  MOUSSY, Alain ,  CROISY, Martine

IPC分类号： A61K31/421 ,  A61K31/427 ,  A61K31/4439 ,  C07D263/48

CPC分类号： C07D263/48 ,  C07D263/46 ,  C07D263/58 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

公开(公告)号：EP2366703A1

公开(公告)日：2011-09-21

申请号：EP11170200.7

申请日：2008-02-13

申请人： AB Science

发明人： Moussy, Alain ,  Reginault, Philippe ,  Bellamy, François ,  Lermet, Anne

IPC分类号： C07D417/04

CPC分类号： C07D417/04

摘要： The present invention relates to a polymorph form of 4-(4-Methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-phenyl]-benzamide, and to a process for the preparation thereof.

摘要翻译： 本发明涉及多晶型形式的4-（4-甲基 - 哌嗪-1-基甲基）-N- [4-甲基-3-（4-吡啶-3-基 - 噻唑-2-基氨基） - 苯基] - 苯甲酰胺，以及其制备方法。