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1.发明授权
公开(公告)号：EP1684750B1
公开(公告)日：2010-04-28
申请号：EP04791783.6
申请日：2004-10-22
发明人： MOUSSY, Alain , WERMUTH, Camille , GRIERSON, David , BENJAHAD, Abdellah , CROISY, Martine , CIUFOLINI, Marco , GIETHLEN, Bruno
IPC分类号： A61K31/422
CPC分类号： C07D263/48 , C07D413/04 , C07D413/14 , E21B33/038 , E21B43/121
摘要： The present invention relates to novel compounds selected from 2-aminoaryloxazoles of formula I that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl, FGFR3 and/or Flt-3 inhibitors.
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2.发明公开SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS 有权取代的唑衍生物及其作为酪氨酸激酶抑制剂的使用
公开(公告)号：EP1874305A2
公开(公告)日：2008-01-09
申请号：EP06755876.7
申请日：2006-04-04
IPC分类号： A61K31/421 , A61K31/427 , A61K31/4439 , C07D263/48
CPC分类号： C07D263/48 , C07D263/46 , C07D263/58 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl and Fit- 3 inhibitors.
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3.发明公开
公开(公告)号：EP1684750A2
公开(公告)日：2006-08-02
申请号：EP04791783.6
申请日：2004-10-22
发明人： MOUSSY, Alain , WERMUTH, Camille , GRIERSON, David , BENJAHAD, Abdellah , CROISY, Martine , CIUFOLINI, Marco , GIETHLEN, Bruno
IPC分类号： A61K31/422
CPC分类号： C07D263/48 , C07D413/04 , C07D413/14 , E21B33/038 , E21B43/121
摘要： The present invention relates to novel compounds selected from 2-aminoaryloxazoles of formula I that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl, FGFR3 and/or Flt-3 inhibitors.
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4.发明授权SUBSTITUTED OXAZOLE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS 有权取代的唑衍生物及其作为酪氨酸激酶抑制剂的使用
公开(公告)号：EP1874305B1
公开(公告)日：2014-08-27
申请号：EP06755876.7
申请日：2006-04-04
IPC分类号： A61K31/421 , A61K31/427 , A61K31/4439 , C07D263/48
CPC分类号： C07D263/48 , C07D263/46 , C07D263/58 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12
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5.发明授权
公开(公告)号：EP1318995B1
公开(公告)日：2006-03-08
申请号：EP01980812.0
申请日：2001-09-18
发明人： GUILLEMONT, Jérôme , BENJAHAD, Abdellah , MABIRE, Dominique , N'GUYEN, Chi, Hung , GRIERSON, David , MONNERET, Claude , BISAGNI, Emile , SANZ, Gérard , DECRANE, Laurence
IPC分类号： C07D401/12 , C07D213/78 , C07D407/06 , C07D417/06 , C07D401/06 , C07D213/71 , C07D405/04 , C07D213/82 , C07D213/70 , C07D213/69 , C07D409/12 , C07D417/12 , C07D405/12 , C07D491/04 , C07D215/22
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D213/78 , C07D213/80 , C07D213/82 , C07D213/85 , C07D213/89 , C07D215/22 , C07D215/227 , C07D215/36 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/06 , C07D407/12 , C07D407/14 , C07D409/04 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/04
摘要： The present invention is concerned among others with compounds of formula (1), the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein Q is halo, C1-6 alkyl or C2-6 alkenyl; X is (a-2) with q and r being O and Z being O, S or SO; R1 is aryl; R2 is selected from formyl; C1-6alkyloxycarbonylalkyl; Het?2; Het2C¿1-6alkyl, C1-6alkylthio; C1-6alkyl optionally substituted with one or two substituents each independently selected from hydroxy, and halo; R3 is selected from formyl; C1-6alkyl optionally substituted with one or two C1-6alkyloxy; R4 is hydrogen, with HIV inhibiting properties.
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6.发明公开
公开(公告)号：EP1318995A2
公开(公告)日：2003-06-18
申请号：EP01980812.0
申请日：2001-09-18
发明人： GUILLEMONT, Jérôme , BENJAHAD, Abdellah , MABIRE, Dominique , N'GUYEN, Chi, Hung , GRIERSON, David , MONNERET, Claude , BISAGNI, Emile , SANZ, Gérard , DECRANE, Laurence
IPC分类号： C07D401/12 , C07D213/78 , C07D407/06 , C07D417/06 , C07D401/06 , C07D213/71 , C07D405/04 , C07D213/82 , C07D213/70 , C07D213/69 , C07D409/12 , C07D417/12 , C07D405/12 , C07D491/04 , C07D215/22
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/71 , C07D213/78 , C07D213/80 , C07D213/82 , C07D213/85 , C07D213/89 , C07D215/22 , C07D215/227 , C07D215/36 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/06 , C07D407/12 , C07D407/14 , C07D409/04 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D491/04
摘要： The present invention is concerned among others with compounds of formula (1), the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein Q is halo, C1-6 alkyl or C2-6 alkenyl; X is (a-2) with q and r being O and Z being O, S or SO; R1 is aryl; R2 is selected from formyl; C1-6alkyloxycarbonylalkyl; Het?2; Het2C¿1-6alkyl, C1-6alkylthio; C1-6alkyl optionally substituted with one or two substituents each independently selected from hydroxy, and halo; R3 is selected from formyl; C1-6alkyl optionally substituted with one or two C1-6alkyloxy; R4 is hydrogen, with HIV inhibiting properties.
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公开(公告)号：EP3253749A1
公开(公告)日：2017-12-13
申请号：EP16703138.4
申请日：2016-02-05
申请人： AB Science
发明人： MOUSSY, Alain , BENJAHAD, Abdellah , PEZ, Didier , SANDRINELLI, Franck , MARTIN, Jason , PICOUL, Willy , CHEVENIER, Emmanuel
IPC分类号： C07D413/14 , C07D413/10 , C07D417/10 , A61K31/439 , A61K31/4155 , A61K31/4178 , A61K31/5377 , A61K31/496 , A61K31/4196 , A61K31/4192 , A61K31/427 , A61P35/00 , C07D417/14
CPC分类号： C07D413/10 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/5377 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present invention relates to compounds of general formula (I). wherein A represents an optionally substituted heterocyclyl group, B represents an aryl or heteroaryl group and wherein X, R1, R2, R3, R4 and R5 are as defined in the description. Compounds of formula (I) are useful to destroy, inhibit, or prevent the growth or spread of cells, especially malignant cells, into surrounding tissues implicated in a variety of human and animal diseases
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8.发明授权OXAZOLE AND THIAZOLE DERIVATIVES AS SELECTIVE PROTEIN KINASE INHIBITORS (C-KIT) 有权恶唑和噻唑衍生物，以作为选择性蛋白激酶抑制剂（C-KIT）
公开(公告)号：EP2736904B1
公开(公告)日：2016-03-16
申请号：EP12741307.8
申请日：2012-07-24
申请人： AB Science
发明人： BENJAHAD, Abdellah , MOUSSY, Alain , CHEVENIER, Emmanuel , PICOUL, Willy , LERMET, Anne , PEZ, Didier , MARTIN, Jason , SANDRINELLI, Franck
IPC分类号： C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , A61P35/00 , A61K31/422 , A61K31/427
CPC分类号： A61K31/422 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14
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公开(公告)号：EP2523952B1
公开(公告)日：2015-03-04
申请号：EP11702802.7
申请日：2011-01-12
申请人： AB Science
发明人： MOUSSY, Alain , BENJAHAD, Abdellah , MARTIN, Jason , CHEVENIER, Emmanuel , PEZ, Didier , SANDRINELLI, Franck , PICOUL, Willy
IPC分类号： C07D413/12 , C07D413/14 , C07D417/14 , A61K31/443 , A61K31/444 , A61K31/4436 , A61P35/00 , A61P37/00
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
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公开(公告)号：EP2523952A1
公开(公告)日：2012-11-21
申请号：EP11702802.7
申请日：2011-01-12
申请人： AB Science
发明人： MOUSSY, Alain , BENJAHAD, Abdellah , MARTIN, Jason , CHEVENIER, Emmanuel , PEZ, Didier , SANDRINELLI, Franck , PICOUL, Willy
IPC分类号： C07D413/12 , C07D413/14 , C07D417/14 , A61K31/443 , A61K31/444 , A61K31/4436 , A61P35/00 , A61P37/00
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： The present invention is concerned with substituted azole derivatives that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. In particular, several of these compounds are potent and selective Flt-3 inhibitors or/and syk inhibitors.
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