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    ORAL COMPOSITION COMPRISING 5-AMINOSALICYCLIC ACID
    53.
    发明公开
    ORAL COMPOSITION COMPRISING 5-AMINOSALICYCLIC ACID 失效
    口腔编译S-氨基CONTAINS

    公开(公告)号：EP0951287A2

    公开(公告)日：1999-10-27

    申请号：EP97918973.0

    申请日：1997-08-12

    申请人： TILLOTTS PHARMA AG

    发明人： BUSER, Thomas

    IPC分类号： A61K47 ,  A61K9 ,  A61K31 ,  A61P29

    CPC分类号： A61K31/606 ,  A61K9/006 ,  A61K9/1274 ,  A61K47/14

    摘要： A topical spreadable composition comprising 5-aminosalicylic acid (5-ASA) as active and monoolein is provided for treatment ulcers, inflammation and lesions of the oral cavity. The composition is spread over and adheres to the lesion, and is preferably prepared in a water free state. Examples of indications that can be treated are oral Crohn's Disease, apthous ulcers, orofacial granulomatosis, oral ulcers associated with Behet's disease and oral lichen planus.

    DELAYED RELEASE ORAL DOSAGE FORMS FOR TREATMENT OF INTESTINAL DISORDERS
    55.
    发明授权
    DELAYED RELEASE ORAL DOSAGE FORMS FOR TREATMENT OF INTESTINAL DISORDERS 失效
    口服剂型持续释放肠道疾病的治疗。

    公开(公告)号：EP0572486B1

    公开(公告)日：1995-11-08

    申请号：EP92905384.1

    申请日：1992-02-21

    申请人： TILLOTTS PHARMA AG

    发明人： RHODES, John ,  EVANS, Brian Kenneth

    IPC分类号： A61K9/50 ,  A61K9/48

    CPC分类号： A61K9/4891 ,  A61K9/5026 ,  A61K31/415 ,  A61K31/65 ,  A61K33/245 ,  A61K47/52 ,  A61K47/58 ,  A61K2300/00

    摘要： An orally administrable pharmaceutical dosage form for selectively administering a drug to the intestine comprises a plurality of enteric coated granules of the drug contained in an enterically coated capsule which releases the granules in the small intestine. The granules are preferably coated with a coating which remains intact until the coated granules reach at least the ileum and thereafter provide a sustained release of the drug in the colon. Suitable coating materials are selected from the Eudragit range of (meth)acrylate and (meth)acrylic acid polymers. The invention has particular application to topically active drugs such as topically active steroids, bismuth salts and complexes, and especially, 5-amino-salicylic acid.