公开(公告)号：EP4327875A3

公开(公告)日：2024-05-22

申请号：EP23210115.4

申请日：2019-04-25

申请人： Smilebiotek Zhuhai Limited

发明人： WEI, Lai

IPC分类号： C12Q1/18 ,  A01K67/02 ,  A61K49/00 ,  A61P31/00 ,  A61P27/02

CPC分类号： C12N1/20 ,  C12Q1/025 ,  A61K49/0008 ,  A61K31/43 ,  A61K31/7036 ,  A61K31/4164 ,  A61K31/65 ,  G01N33/5088 ,  G01N2800/1620130101 ,  G01N2500/1020130101 ,  A61K35/742 ,  A61K35/747 ,  A61K35/744 ,  A61K2035/11520130101 ,  Y02A50/30 ,  C12Q1/18

摘要： Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD). For example, provided herein are screening methods for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. The screening method can be an in vitro screening method or an in vivo screening method, e.g., using an animal model described herein. Animal models are also provided herein, for example, for screening candidate therapeutics for treating or preventing eye diseases, such as AMD. Methods of preparing the animal models are also described herein. Methods of treating or preventing AMD are also provided.

公开(公告)号：EP2609162B1

公开(公告)日：2018-12-12

申请号：EP11754961.8

申请日：2011-08-25

申请人： Tyrx, Inc.

发明人： PULAPURA, Satish ,  GE, Qing

IPC分类号： C09D171/02

CPC分类号： A61L31/10 ,  A61K31/155 ,  A61K31/496 ,  A61K31/65 ,  A61K33/38 ,  A61L31/16 ,  A61L2300/204 ,  A61L2300/216 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/06 ,  C09D5/14 ,  C09D171/02 ,  Y02A50/406 ,  Y10T428/265 ,  Y10T428/31678 ,  C08L71/02 ,  C08L67/02

摘要： The present invention relates to coatings comprising polyethylene glycol and at least one polyphenolic polymer. In particular, the polyphenolic polymer could be selected from the group consisting of tyrosine-derived polyarylates, linear polyesteramides, dihydroxybenzoate polymers, and resorcinol-derived polymers. The coating of the present invention may also include a drug, such as an antibiotic. The coatings of the present invention are suitable for use as coatings for medical devices, such as orthopedic pins or stents.

公开(公告)号：EP3370794A1

公开(公告)日：2018-09-12

申请号：EP16806326.1

申请日：2016-11-04

申请人： Board of Regents, The University of Texas System

发明人： ROSENBLATT, Joel ,  RAAD, Issam

IPC分类号： A61L29/16 ,  A01N31/02 ,  A01N37/44 ,  A01N43/54

CPC分类号： A61L29/16 ,  A01N25/02 ,  A01N25/22 ,  A01N31/02 ,  A01N45/00 ,  A61J1/2096 ,  A61K31/505 ,  A61K31/65 ,  A61L29/143 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/45 ,  A61M5/178 ,  A61M25/00 ,  A61M2025/0019 ,  Y02A50/473 ,  A01N37/44

摘要： Provided are antimicrobial solutions, including catheter lock solutions. In some embodiments, the solution contains an antibiotic (e.g., minocycline or trimethoprim), EDTA, and an alcohol (e.g., ethanol), wherein the pH of the solution is adjusted to about 6-8 to reduce precipitation. Methods of using the solutions and kits are also provided.

公开(公告)号：EP3347024A2

公开(公告)日：2018-07-18

申请号：EP16763756.0

申请日：2016-09-07

申请人： Ecole Polytechnique Fédérale de Lausanne (EPFL)

发明人： ZHANG, Hongbo ,  MENZIES, Keir ,  AUWERX, Johan ,  RYU, Dongryeol

IPC分类号： A61K31/65 ,  A61K31/165 ,  A61K31/706 ,  A61K45/06 ,  A61K38/18 ,  A61K35/34 ,  C12N5/00 ,  A61P21/06 ,  A23L33/10 ,  A23L33/13

CPC分类号： A61K31/706 ,  A23L33/10 ,  A23L33/13 ,  A23V2002/00 ,  A61K31/165 ,  A61K31/65 ,  A61K35/34 ,  A61K38/1825 ,  A61K45/06 ,  A61P21/00 ,  C12N5/0658 ,  C12N2501/10 ,  C12N2501/999 ,  A61K2300/00

摘要： The present invention relates to agents that induce mitochondrial unfolded protein response (UPR mt) in muscle stem cells and prevents or reverse process of muscle stem cell senescence. Further, the invention relates to methods and compositions useful in the prevention and/or treatment of muscle stem senescence.

公开(公告)号：EP3339348A1

公开(公告)日：2018-06-27

申请号：EP17195684.0

申请日：2006-04-21

申请人： Universite De Geneve

发明人： MÖLLER, Michael ,  TRIMAILLE, Thomas ,  GURNY, Robert

IPC分类号： C08G63/08

CPC分类号： A61K47/34 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/1075 ,  A61K31/65 ,  C08G63/08 ,  C08G63/823

摘要： The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solent is not required.

公开(公告)号：EP3199163A4

公开(公告)日：2018-06-20

申请号：EP15845327

申请日：2015-09-23

申请人： AGENCIA PUBLICA EMPRESARIAL SANITARIA HOSPITAL ALTO GUADALQUIVIR

发明人： VILLEGAS BECERRIL ENRIQUE

IPC分类号： A61K31/65 ,  A61K9/00 ,  A61K9/127 ,  A61K36/28 ,  A61K36/53 ,  A61K36/886 ,  A61P27/02

CPC分类号： A61K36/53 ,  A61K9/0048 ,  A61K9/127 ,  A61K31/65 ,  A61K36/28 ,  A61K36/886

摘要： The invention relates to use of a composition comprising doxycycline in the production of a topically administered medicament for the prevention, improvement and/or treatment of ocular disorders.

公开(公告)号：EP2895160B1

公开(公告)日：2018-05-30

申请号：EP13762485.4

申请日：2013-09-13

申请人： Nogra Pharma Limited

发明人： GIULIANI, Giammaria ,  PAUS, Ralf ,  RAMOT, Yuval ,  BARONI, Sergio ,  VITI, Francesca ,  BELLINVIA, Salvatore ,  MARZANI, Barbara

IPC分类号： A61K31/196 ,  A61K8/42 ,  A61Q7/00 ,  A61K45/06 ,  A61P17/14

CPC分类号： A61K31/196 ,  A61K8/42 ,  A61K8/4973 ,  A61K8/498 ,  A61K9/0014 ,  A61K31/132 ,  A61K31/4439 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/65 ,  A61K31/7056 ,  A61K45/06 ,  A61Q7/00 ,  A61K2300/00

摘要： Provided herein are methods for enhancing epidermal regeneration in a patient in need thereof, comprising topically administering to said patient a pharmaceutically acceptable composition comprising N-acetyl-3-(4-aminophenyl)-2-methoxypropionic acid or a pharmaceutically acceptable salt or stereoisomer thereof, and a pharmaceutically acceptable excipient. For example, provided are methods for treating or ameliorating cicatricial alopecia, comprising topically administering to a patient in need thereof a pharmaceutically acceptable composition comprising the disclosed compounds. Also provided are methods for protecting hair follicle progenitor cells and compositions comprising same using the disclosed compounds.

公开(公告)号：EP3200748A4

公开(公告)日：2018-05-23

申请号：EP15846726

申请日：2015-09-27

申请人： POLYPID LTD

发明人： EMANUEL NOAM

IPC分类号： A61L27/34 ,  A61K6/06 ,  A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K9/52 ,  A61K9/70 ,  A61K31/575 ,  A61K31/65 ,  A61K31/685 ,  A61K45/06 ,  A61P31/04

CPC分类号： A61K9/1676 ,  A61K9/0024 ,  A61K9/146 ,  A61K9/148 ,  A61K9/1611 ,  A61K9/1635 ,  A61K9/1682 ,  A61K9/70 ,  A61K31/575 ,  A61K31/65 ,  A61K31/685 ,  A61K45/06

摘要： The present invention provides methods for preventing, inhibiting or treating a surgical site infection associated with a surgical operation comprising the step of applying to the surgical site a biocompatible, biodegradable substrate being impregnated and/or having its surface coated fully or partially with a matrix composition which provides local controlled and prolonged release of at least one pharmaceutically active agent at the surgical site.

公开(公告)号：EP3310353A1

公开(公告)日：2018-04-25

申请号：EP16811091.4

申请日：2016-06-16

申请人： Translatum Medicus, Inc.

发明人： BOYD, Shelley, Romayne

IPC分类号： A61K31/416 ,  A61P27/02 ,  A61P9/10 ,  C07D231/56

CPC分类号： A61K31/416 ,  A61K9/0048 ,  A61K9/0053 ,  A61K31/133 ,  A61K31/436 ,  A61K31/498 ,  A61K31/585 ,  A61K31/65 ,  A61K38/03 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2300/00 ,  A61P27/02

摘要： Disclosed herein are methods, compounds, and compositions that are useful for the diagnosis, treatment, or prevention of an ocular disorder, including in the discovery of agents that are efficacious against these disorders.

公开(公告)号：EP3277330A1

公开(公告)日：2018-02-07

申请号：EP16773584.4

申请日：2016-03-31

申请人： Orchid Medical Pte Ltd

发明人： WANG, Honglei ,  LUO, Jingnan

IPC分类号： A61L29/14 ,  A61L31/14 ,  A61L31/10 ,  A61L31/16

CPC分类号： A61L31/16 ,  A61K31/496 ,  A61K31/65 ,  A61L27/54 ,  A61L27/58 ,  A61L31/041 ,  A61L31/06 ,  A61L31/148 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/602 ,  A61N1/375 ,  A61P31/00

摘要： There is provided a controlled-release antibiotic socket for securely holding an implantable medical device that is made from: at least one film having at least one polymer layer, where the at least one film is formed into the socket; at least one antibiotic agent; and at least one opening in the socket, where the at least one polymer layer comprises a biodegradable elastomeric polymeric material; and the at least one antibiotic agent is dispersed within at least one of the at least one polymer layers and/or, when the film comprises at least two polymer layers, the at least one antibiotic agent is disposed as a separate layer between two polymer layers. Also disclosed is the film used to make the socket and uses of both the socket and film.