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公开(公告)号：EP3890707A1
公开(公告)日：2021-10-13
申请号：EP19816318.0
申请日：2019-12-05
申请人： Tillotts Pharma AG
IPC分类号： A61K9/20 , A61K9/28 , A61K31/606
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公开(公告)号：EP2844222B1
公开(公告)日：2019-11-13
申请号：EP13723033.0
申请日：2013-04-29
申请人： TILLOTTS PHARMA AG
发明人： BRAVO GONZÁLEZ, Roberto Carlos , BUSER, Thomas , GOUTTE, Frédéric Jean-Claude , BASIT, Abdul, Waseh , VARUM, Felipe, José, Oliveria , FREIRE, Ana, Cristina
IPC分类号： A61K9/00 , A61K9/28 , A61K31/606 , A61K47/32 , A61K47/36
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公开(公告)号：EP3890711A1
公开(公告)日：2021-10-13
申请号：EP19816319.8
申请日：2019-12-05
申请人： Tillotts Pharma AG
IPC分类号： A61K9/28 , A61K31/606
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公开(公告)号：EP2844220B1
公开(公告)日：2019-01-23
申请号：EP13719543.4
申请日：2013-04-29
申请人： TILLOTTS PHARMA AG
发明人： BRAVO GONZÁLEZ, Roberto Carlos , BUSER, Thomas , GOUTTE, Frédéric Jean-Claude , BASIT, Abdul, Waseh , VARUM, Felipe, José, Oliveira , FREIRE, Ana,Cristina
IPC分类号： A61K9/00 , A61K9/28 , A61K31/606 , A61K47/32 , A61K47/36 , A61K31/196 , A61K31/616
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公开(公告)号：EP3890709A1
公开(公告)日：2021-10-13
申请号：EP19816316.4
申请日：2019-12-05
申请人： Tillotts Pharma AG
IPC分类号： A61K9/28
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公开(公告)号：EP3187171A1
公开(公告)日：2017-07-05
申请号：EP17157257.1
申请日：2012-04-30
申请人： Tillotts Pharma AG
发明人： BRAVO GONZÁLEZ, Roberto Carlos , BUSER, Thomas , GOUTTE, Frédéric Jean-Claude , BASIT, Abdul Waseh , VARUM, Felipe José Oliveira , FREIRE, Ana Cristina
IPC分类号： A61K9/00 , A61K9/28 , A61K31/616 , A61K31/196 , A61K47/32 , A61K47/36
CPC分类号： A61K9/2886 , A61K9/0053 , A61K9/2013 , A61K9/2054 , A61K9/284 , A61K9/2846 , A61K9/2853 , A61K9/286 , A61K9/2866 , A61K9/288 , A61K9/2893 , A61K31/196 , A61K31/606 , A61K31/616 , A61K47/32 , A61K47/36 , A61K47/38
摘要： Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a non-ionic polymer as a third polymeric material which is soluble in intestinal fluid, together with a buffer agent and/or a base.
摘要翻译： 药物向结肠的延迟释放是由包含核心和核心包衣的延迟释放制剂实现的。 芯包含药物并且涂层包含内层和外层。 外层包含易受结肠细菌侵袭的第一聚合物材料和具有约pH 5或以上的pH阈值的第二聚合物材料的混合物。 内层包含非离子聚合物作为可溶于肠液的第三种聚合物材料以及缓冲剂和/或碱。
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公开(公告)号：EP3189830B1
公开(公告)日：2018-05-23
申请号：EP17156227.5
申请日：2013-04-29
申请人： Tillotts Pharma AG
发明人： BRAVO GONZÁLEZ, Roberto Carlos , BUSER, Thomas , GOUTTE, Frédéric Jean-Claude , BASIT, Abdul, Waseh , VARUM, Felipe, José, Oliveria , FREIRE, Ana, Cristina
IPC分类号： A61K9/00 , A61K9/20 , A61K9/28 , A61K31/606 , A61K47/32 , A61K47/36 , A61K31/196 , A61K31/616
CPC分类号： A61K9/2886 , A61K9/0053 , A61K9/2013 , A61K9/2054 , A61K9/284 , A61K9/2846 , A61K9/2853 , A61K9/286 , A61K9/2866 , A61K9/288 , A61K9/2893 , A61K31/196 , A61K31/606 , A61K31/616 , A61K47/32 , A61K47/36 , A61K47/38
摘要： Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid.
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公开(公告)号：EP3062776A1
公开(公告)日：2016-09-07
申请号：EP13785437.8
申请日：2013-10-29
申请人： Tillotts Pharma AG
发明人： VARUM, Felipe José Oliveira , BRAVO GONZÁLEZ, Roberto Carlos , BUSER, Thomas , BASIT, Abdul Waseh , FREIRE, Ana Cristina
CPC分类号： A61K31/606 , A61J3/005 , A61K9/0053 , A61K9/284 , A61K9/2846 , A61K9/2866 , A61K9/2886 , A61K9/2893
摘要： In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.
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公开(公告)号：EP2844220A1
公开(公告)日：2015-03-11
申请号：EP13719543.4
申请日：2013-04-29
申请人： TILLOTTS PHARMA AG
发明人： BRAVO GONZÁLEZ, Roberto Carlos , BUSER, Thomas , GOUTTE, Frédéric Jean-Claude , BASIT, Abdul, Waseh. , VARUM, Felipe, José, Oliveria. , FREIRE, Ana,Cristina.
IPC分类号： A61K9/00 , A61K9/28 , A61K31/606 , A61K47/32 , A61K47/36
CPC分类号： A61K9/2886 , A61K9/0053 , A61K9/2013 , A61K9/2054 , A61K9/284 , A61K9/2846 , A61K9/2853 , A61K9/286 , A61K9/2866 , A61K9/288 , A61K9/2893 , A61K31/196 , A61K31/606 , A61K31/616 , A61K47/32 , A61K47/36 , A61K47/38
摘要： Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid.
摘要翻译： 药物向结肠的延迟释放是由包含核心和核心包衣的延迟释放制剂实现的。 芯包含药物并且涂层包含内层和外层。 外层包含易受结肠细菌侵袭的第一聚合物材料和具有约pH 5或以上的pH阈值的第二聚合物材料的混合物。 内层包含可溶于肠液或胃肠液的第三聚合物材料，所述第三聚合物材料选自至少部分中和的多元羧酸和非离子聚合物。 在其中第三聚合物材料是非离子聚合物的实施方案中，内层包含缓冲剂和碱中的至少一种。 根据本发明的制剂的优点包括当暴露于结肠条件时加速释放药物并减少或消除给药后药物释放的食物和/或酒精效应。
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公开(公告)号：EP3278792B1
公开(公告)日：2019-02-20
申请号：EP17188821.7
申请日：2013-04-29
申请人： Tillotts Pharma AG
发明人： BRAVO GONZÁLEZ, Roberto Carlos , BUSER, Thomas , GOUTTE, Frédéric Jean-Claude , BASIT, Abdul, Waseh , VARUM, Felipe, José, Oliveria , FREIRE, Ana, Cristina
IPC分类号： A61K9/00 , A61K9/28 , A61K31/606 , A61K47/32 , A61K47/36 , A61K9/20 , A61K31/196 , A61K31/616
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