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    VERFAHREN ZUM BESCHICHTEN VON TABLETTEN
    54.
    发明公开
    VERFAHREN ZUM BESCHICHTEN VON TABLETTEN 有权
    方法片剂包衣

    公开(公告)号：EP2306987A1

    公开(公告)日：2011-04-13

    申请号：EP09772483.5

    申请日：2009-07-01

    Applicant: BASF SE

    Inventor： KOLTER, Karl ,  ROTTMANN, Nils ,  ANGEL, Maximilian

    IPC: A61K9/28

    CPC classification number: A61K9/284 ,  A61K9/2853

    Abstract: The present invention relates to a polymer composition for coating solid substrates (S) comprising: a) 0.5-90 wt.-% polyethylene glycol with a weight-averaged molecular weight in the range of 1,500 to 20,000 g/mol (Component A), b) 0.5-20 wt.-% of a water-soluble polyvinyl pyrolidone with a K value according to Fikentscher in the range of 12 to 90 (Component B), c) 0-95 wt.-% of a solvent (L), and d) 0-70 wt.-% of one or more non-polymeric auxiliaries (Component C).

    PHARMAZEUTISCHE FORMULIERUNG FÜR DIE HERSTELLUNG VON SCHNELL ZERFALLENDEN TABLETTEN
    55.
    发明公开
    PHARMAZEUTISCHE FORMULIERUNG FÜR DIE HERSTELLUNG VON SCHNELL ZERFALLENDEN TABLETTEN 有权
    PHARMAZEUTISCHE FORMULIERUNGFÜRDIE HERSTELLUNG VON SCHNELL ZERFALLENDEN TABLETTEN

    公开(公告)号：EP2164462A2

    公开(公告)日：2010-03-24

    申请号：EP08760389.0

    申请日：2008-06-03

    Applicant: BASF SE

    Inventor： KOLTER, Karl ,  SCHÖNHERR, Michael ,  GEBERT, Silke ,  MEYER-BÖHM, Kathrin ,  MASCHKE, Angelika

    IPC: A61K9/00 ,  A61K9/20 ,  A61K9/16

    CPC classification number: A61K9/2018 ,  A61K9/0056 ,  A61K9/2027 ,  A61K9/2054

    Abstract: The invention relates to a pharmaceutical formulation in the form of agglomerates containing A) an adjuvant consisting of a) 60 - 97 % by weight of sugar or sugar alcohols, b) 1 - 25 % by weight of a disintegration agent c)1 - 15 % by weight of water insoluble, film-forming polymers d) 0 -15 % by weight of water soluble polymers, and e) 0 - 15 % by weight of additional conventional pharmaceutical adjuvants, the sum of the components a) to e) totalling 100 % by weight, and B) at least one active ingredient.

    Abstract translation: 本发明涉及附聚物形式的药物制剂，其含有A）佐剂，其包含a）60-97重量％的糖或糖醇，b）1-25重量％的崩解剂c）1-15 重量％的水不溶性成膜聚合物，d）0-15％重量的水溶性聚合物，和e）0-15％重量的另外的常规药物佐剂，组分a）-e）总量 100重量％，和B）至少一种活性成分。

    PHARMAZEUTISCHE FORMULIERUNG FÜR DIE HERSTELLUNG VON SCHNELL ZERFALLENDEN TABLETTEN
    57.
    发明公开
    PHARMAZEUTISCHE FORMULIERUNG FÜR DIE HERSTELLUNG VON SCHNELL ZERFALLENDEN TABLETTEN 有权
    药物制剂FOR FAST崩解片剂的制造

    公开(公告)号：EP2164460A1

    公开(公告)日：2010-03-24

    申请号：EP08760350.2

    申请日：2008-06-02

    Applicant: BASF SE

    Inventor： KOLTER, Karl ,  SCHÖNHERR, Michael ,  GEBERT, Silke ,  MEYER-BÖHM, Kathrin ,  MASCHKE, Angelika

    IPC: A61K9/00 ,  A61K9/20 ,  A61K47/26

    CPC classification number: A61K9/0056 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054

    Abstract: The invention relates to a pharmaceutical formulation in the form of compacts containing A) an agglomerated auxiliary agent fraction consisting of a1) 60 - 97 % by weight of sugar or sugar alcohols, a2) 1 - 25 % by weight of a disintegration agent selected from the group consisting of crospovidone, croscarmellose, sodium carboxymethyl starch and L-hydroxypropyl cellulose, a3) 1 - 15 % by weight of water insoluble film-forming polymers, a4) 0 - 15 % by weight of water-soluble polymers, and a5) 0 - 15 % by weight of additional conventional pharmaceutical adjuvants, the sum of the components a1) to a5) totalling 100 % by weight, B) at least one active ingredient, C) 0 to 10 % by weight, in relation to the total quantity and A) to D) of a lubricant or mould release agent, and D) optionally additional pharmaceutical auxiliary agents.

    Abstract translation: 在压坯包括a1的组成A）凝聚的赋形剂含量）为60〜97％（重量）的糖或糖醇的形式的药物制剂，A2）（重量）的崩解剂1-25％，选自交聚维酮中选出， 联羧甲基纤维素，羧甲基淀粉钠和L-羟丙基纤维素，a3）的（重量）的水不溶性成膜聚合物的A4）（重量）的水溶性聚合物的和a5）0-15％0-15％1-15％（重量）的另外的 药学惯用的赋形剂，总组分a1）至a5的）由100％是重量，B）至少一种活性成分，C）0至重量10％，基于A的总量）至D），的 润滑剂或脱模剂，和D），如果合适的话，另外的药物赋形剂。

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