公开(公告)号：EP1439224A2

公开(公告)日：2004-07-21

申请号：EP04005568.3

申请日：1999-01-27

申请人： Human Genome Sciences, Inc.

发明人： Ruben, Steven M. ,  Ferrie, Ann M. ,  Rosen, Craig A. ,  Florence, Kimberly A. ,  Carter, Kenneth C. ,  Soppet, Daniel R. ,  Yu, Guo-Liang ,  Florence, Charles ,  Young, Paul E. ,  Ni, Jian ,  Feng, Ping ,  Endress, Gregory A. ,  Janat, Fouad

IPC分类号： C12N15/00 ,  C07K14/47

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这种蛋白质的基因的编码区的新型人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病的诊断和治疗方法。

公开(公告)号：EP1145721A3

公开(公告)日：2003-12-03

申请号：EP01108494.4

申请日：1995-06-06

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Li, Yi ,  Ruben, Steven M.

IPC分类号： C07K14/715 ,  A61K38/17 ,  G01N33/68 ,  C07K16/28

CPC分类号： C07K14/7158 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

公开(公告)号：EP1247862A2

公开(公告)日：2002-10-09

申请号：EP02001060.9

申请日：1997-08-13

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Duan, Roxanne D. ,  Ruben, Steven M. ,  Jimenez, Pablo ,  Rampy, Mark, A. ,  Mendrick, Donna ,  Zhang, Jun ,  Ni, Jian ,  Moore, Paul A. ,  Coleman, Timothy, A. ,  Gentz, Reiner L.

IPC分类号： C12N15/12 ,  C12N15/62 ,  C12N15/63 ,  C07K14/50 ,  C07K16/22 ,  A61K38/18 ,  A61K48/00 ,  G01N33/566

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). The invention also relates to inhibiting the action of such polypeptides. This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

公开(公告)号：EP1247530A2

公开(公告)日：2002-10-09

申请号：EP02001059.1

申请日：1997-08-13

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Duan, Roxanne D. ,  Ruben, Steven M. ,  Jimenez, Pablo ,  Rampy, Mark A. ,  Mendrick, Donna ,  Zhang, Jun ,  Ni, Jian ,  Moore, Paul A. ,  Coleman, Timothy A. ,  Gentz, Reiner L.

IPC分类号： A61K38/18

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). The invention also relates to inhibiting the action of such polypeptides. This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

摘要翻译： 刺激角质化细胞增殖的新的分离多肽选自：（I）角质形成细胞生长因子-2（KGF-2）N-末端，C-末端或N-末端和C-末端缺失突变体，其分别包含208 氨基酸序列（A;在说明书中给出），除了至少缺失：（a）（A）的前38个但不多于第一个137个N-末端氨基酸残基; （b）最后的C末端氨基酸残基（Ser208），但不超过最后55个C末端氨基酸残基，其中KGF-2 C-末端缺失突变体的N-末端氨基酸残基为Met1，Thr36 或Cys37; （c）（a）和（b）的组合; 或（II）除了至少一个氨基酸取代之外，与（I）具有至少95％氨基酸同一性或与（I）相同的多肽。 还要求的是：（1）包含KGF-2的亲水区域的分离的多肽，其中所述肽的长度不超过150个氨基酸，并且包含残基41-71,91-109,135-164或181-199 （一个）; （2）编码上述多肽的分离的多核苷酸; （3）制备重组载体的方法，包括将（2）插入载体; （4）通过（3）的方法制备的重组载体; （5）一种制备重组宿主细胞的方法，包括将载体导入宿主细胞; 和（6）通过（5）的方法制备的重组宿主细胞。

公开(公告)号：EP1148127A2

公开(公告)日：2001-10-24

申请号：EP01108495.1

申请日：1995-06-06

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Li, Yi ,  Ruben, Steven M.

IPC分类号： C12N15/12 ,  C07K14/715 ,  G01N33/68 ,  C12Q1/68

CPC分类号： C07K14/7158 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

摘要翻译： 公开了人G-蛋白趋化因子受体多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定这种多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白趋化因子受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白趋化因子受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式的水平的诊断方法。

公开(公告)号：EP1145721A2

公开(公告)日：2001-10-17

申请号：EP01108494.4

申请日：1995-06-06

申请人： HUMAN GENOME SCIENCES, INC.

发明人： Li, Yi ,  Ruben, Steven M.

IPC分类号： A61K38/17 ,  A61K31/70 ,  A61K39/395

CPC分类号： C07K14/7158 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

摘要翻译： 公开了人G蛋白趋化因子受体多肽和编码这些多肽的DNA（RNA）以及通过重组技术生产这种多肽的方法。 还公开了利用这些多肽鉴定这些多肽的拮抗剂和激动剂的方法以及分别用治疗性激动剂和拮抗剂治疗与G蛋白趋化因子受体多肽的低表达和过表达有关的病症的方法。 还公开了用于检测G蛋白趋化因子受体核酸序列中的突变并检测源自宿主的样品中受体的可溶形式水平的诊断方法。