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    Human G-protein chemokine receptor HDGNR10 (CCR5 receptor). Pharmaceutical composition
    1.
    发明公开
    Human G-protein chemokine receptor HDGNR10 (CCR5 receptor). Pharmaceutical composition 失效
    人类G蛋白的趋化因子DHDGNR10（CCR5受体）。 一种药物组合

    公开(公告)号：EP1145721A3

    公开(公告)日：2003-12-03

    申请号：EP01108494.4

    申请日：1995-06-06

    申请人： HUMAN GENOME SCIENCES, INC.

    发明人： Li, Yi ,  Ruben, Steven M.

    IPC分类号： C07K14/715 ,  A61K38/17 ,  G01N33/68 ,  C07K16/28

    CPC分类号： C07K14/7158 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    Human G-protein chemokine receptor HDGNR10 (CCR5 receptor). Its uses
    2.
    发明公开
    Human G-protein chemokine receptor HDGNR10 (CCR5 receptor). Its uses 失效
    Menschlicher G-Protein ChemokinRezepor HDGNR10（CCR5 Rezeptor）。 塞纳Verwendungen

    公开(公告)号：EP1148127A2

    公开(公告)日：2001-10-24

    申请号：EP01108495.1

    申请日：1995-06-06

    申请人： HUMAN GENOME SCIENCES, INC.

    发明人： Li, Yi ,  Ruben, Steven M.

    IPC分类号： C12N15/12 ,  C07K14/715 ,  G01N33/68 ,  C12Q1/68

    CPC分类号： C07K14/7158 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    摘要翻译： 公开了人G-蛋白趋化因子受体多肽和编码这些多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定这种多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白趋化因子受体多肽的低表达和过表达相关的病症的方法。 还公开了用于检测G蛋白趋化因子受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式的水平的诊断方法。

    Human G-protein chemokine receptor HDGNR10 (CCR5 receptor)
    3.
    发明公开
    Human G-protein chemokine receptor HDGNR10 (CCR5 receptor) 失效
    人类G蛋白趋化因子受体HDGNR10（CCR5受体）

    公开(公告)号：EP1145721A2

    公开(公告)日：2001-10-17

    申请号：EP01108494.4

    申请日：1995-06-06

    申请人： HUMAN GENOME SCIENCES, INC.

    发明人： Li, Yi ,  Ruben, Steven M.

    IPC分类号： A61K38/17 ,  A61K31/70 ,  A61K39/395

    CPC分类号： C07K14/7158 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    摘要翻译： 公开了人G蛋白趋化因子受体多肽和编码这些多肽的DNA（RNA）以及通过重组技术生产这种多肽的方法。 还公开了利用这些多肽鉴定这些多肽的拮抗剂和激动剂的方法以及分别用治疗性激动剂和拮抗剂治疗与G蛋白趋化因子受体多肽的低表达和过表达有关的病症的方法。 还公开了用于检测G蛋白趋化因子受体核酸序列中的突变并检测源自宿主的样品中受体的可溶形式水平的诊断方法。

    Human G-protein chemokine receptor HDGNR10 (CCR5 receptor)
    6.
    发明公开
    Human G-protein chemokine receptor HDGNR10 (CCR5 receptor) 失效
    人类G蛋白的趋化因子HDGNR10（CCR5受体）

    公开(公告)号：EP1148126A3

    公开(公告)日：2003-12-03

    申请号：EP01108491.0

    申请日：1995-06-06

    申请人： HUMAN GENOME SCIENCES, INC.

    发明人： Li, Yi ,  Ruben, Steven M.

    IPC分类号： C07K14/715 ,  A61K38/17 ,  G01N33/68 ,  C07K16/28

    CPC分类号： C07K14/7158 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    Human G-protein chemokine receptor HDGNR10 (CCR5 receptor)
    7.
    发明公开
    Human G-protein chemokine receptor HDGNR10 (CCR5 receptor) 失效
    人类G蛋白的趋化因子HDGNR10（CCR5受体）

    公开(公告)号：EP1146122A3

    公开(公告)日：2003-12-03

    申请号：EP01108492.8

    申请日：1995-06-06

    申请人： HUMAN GENOME SCIENCES, INC.

    发明人： Li, Yi ,  Ruben, Steven M.

    IPC分类号： C12N15/12 ,  C07K14/715 ,  C12N5/10 ,  C12N1/21

    CPC分类号： C07K14/7158 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

    Antibody against Human G-protein chemokine receptor HDGNR10 (CCR5 receptor)
    8.
    发明公开
    Antibody against Human G-protein chemokine receptor HDGNR10 (CCR5 receptor) 失效
    针对G蛋白的趋化因子HDGNR10人抗体（CCR5受体）

    公开(公告)号：EP1146055A3

    公开(公告)日：2003-12-03

    申请号：EP01108496.9

    申请日：1995-06-06

    申请人： HUMAN GENOME SCIENCES, INC.

    发明人： Li, Yi ,  Ruben, Steven M.

    IPC分类号： C07K14/715 ,  A61K38/17 ,  G01N33/68 ,  C07K16/28

    CPC分类号： C07K14/7158 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.