公开(公告)号：EP1206275B1

公开(公告)日：2007-09-05

申请号：EP99956954.4

申请日：1999-11-05

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  PALMER, Pamela, P. ,  HERZ, Jeffrey, M.

IPC分类号： A61K38/17 ,  A61P41/00

CPC分类号： A61K45/06 ,  A61K9/08 ,  A61K38/1793 ,  A61K2300/00

摘要： A method an solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one soluble receptor and, optionally, multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a soluble receptor, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a ν-opioid agonist.

公开(公告)号：EP1567179A1

公开(公告)日：2005-08-31

申请号：EP02793939.6

申请日：2002-11-12

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  PALMER, Pamela, Pierce ,  HERZ, Jeffrey, M. ,  TANELIAN, Darrell

IPC分类号： A61K38/00 ,  A61K31/70 ,  A61K31/55 ,  A61K31/54 ,  A61K31/495 ,  A61K31/505 ,  A61K39/395 ,  A61K39/00

CPC分类号： A61K45/06 ,  A61K31/495 ,  A61K31/505 ,  A61K31/54 ,  A61K31/55 ,  A61K31/70 ,  A61K38/06 ,  A61K38/08 ,  A61K38/177 ,  A61K38/178 ,  A61K2300/00

摘要： A method and solution for perioperatively inhibiting tumor cell adhesion and a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one anti-tumor cell adhesion agent and multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit tumor cell adhesion, pain and inflammation includes at least one anti-tumor cell adhesion agent, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokininl antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykininl antagonist, a bradykinin2 antagonist and a ν-opioid agonist.

公开(公告)号：EP1534313A2

公开(公告)日：2005-06-01

申请号：EP03772122.2

申请日：2003-07-30

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  PALMER, Pamela, Pierce ,  HERZ, Jeffrey, M.

IPC分类号： A61K38/00 ,  A61K31/56 ,  A61K31/19

CPC分类号： A61K31/573 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/00 ,  A61K31/137 ,  A61K31/167 ,  A61K31/192 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4409 ,  A61K31/445 ,  A61K31/5377 ,  A61K45/06

摘要： Solutions for perioperative intraocular application by continuous irrigation during ophthalmologic procedures are provided. These solutions include multiple agents that act to inhibit inflammation, inhibit pain, effect mydriasis (dilation of the pupil), and/or decrease intraocular pressure, wherein the multiple agents are selected to target multiple molecular targets to achieve multiple differing physiologic functions, and are included in dilute concentrations in a balanced salt solution carrier.

公开(公告)号：EP1261334A1

公开(公告)日：2002-12-04

申请号：EP99955097.3

申请日：1999-10-20

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  PALMER, Pamela, P. ,  HERZ, Jeffrey, M.

IPC分类号： A61K31/352 ,  A61K31/4439 ,  A61P29/00

CPC分类号： A61K31/352 ,  A61K31/4439 ,  A61K45/06

摘要： A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes at least one mitogen-activated protein kinase (MAPK) inhibitor and, optionally, additional multiple pain and inflammation inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a MAPK inhibitor, a serotonin2 antagonist, a serotonin3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin1 antagonist, a neurokinin2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin1 antagonist, a bradykinin2 antagonist and a ν-opioid agonist.

公开(公告)号：EP1246573A2

公开(公告)日：2002-10-09

申请号：EP00989482.5

申请日：2000-12-22

申请人： Omeros Corporation

发明人： DEMOPULOS, Gregory, A. ,  REED, Scott, W. ,  BACHMAN, Alan, B. ,  KARL, Frederick, T. ,  ALLEN, William, J. ,  ADAMS, Leland, R. ,  THATCHER, Lawrence, G.

IPC分类号： A61B17/08

CPC分类号： A61B17/1146 ,  A61B17/00491 ,  A61B17/064 ,  A61B2017/00004 ,  A61B2017/0609 ,  A61B2017/0647

摘要： A reinforcing member or stent (7) is inserted into opposite end portions (1, 1') of a lacerated tendon and secured within the tendon by adhesive so that tension applied to the tendon is transmitted across the laceration by way of the reinforcing member (7).