摘要:
A method for filtering a protein-containing liquid containing protein at a concentration of 20 mg/mL or more and 100 mg/mL or less, the method including a prefiltration step of filtering the protein-containing liquid by a prefilter having a pore size of 0.08 µm to 0.25 µm and including a hydrophobic resin, and a virus removal step of filtering the protein-containing liquid by a virus removal membrane including a synthetic polymer, after the prefiltration step, wherein the protein-containing liquid before conducting the prefiltration step includes 0.25 g or more of a trimer or higher multimer of the proteins having an average diameter of less than 100 nm, per 1 m 2 of the virus removal membrane.
摘要:
A blood purification apparatus includes a blood circuit, a blood purifier, citric acid solution supply means and calcium solution supply means. The blood purification apparatus is configured to: estimate, based on an input of a target calcium ion concentration for a patient's blood, an amount of calcium loss throughout the blood circuit, including an amount of calcium removed by the blood purifier when blood having the target calcium ion concentration flows through the blood circuit; calculate a flow rate of the calcium solution to be supplied to the blood circuit based on the estimated amount of calcium loss; and supply the calcium solution to the blood circuit by the calcium solution supply means based on the calculated flow rate of the calcium solution.
摘要:
The blood purification system comprises: a blood treatment circuit that supplies blood of a patient to a blood purification unit and returns the blood to the patient; a drainage circuit that discharges drainage from the blood purification unit to a drainage reservoir using a drainage pump; an external drainage circuit that discharges the contents of the drainage reservoir to the outside; a weight scale that measures the weight of the drainage reservoir; and a drainage controller that, when the contents of the drainage reservoir are not being discharged to the outside by the external drainage circuit, calculates the actual flow rate of the drainage pump from a variation of the weight of the drainage reservoir measured by the weight scale and corrects the flow rate error between the actual flow rate and the target flow rate by controlling the drainage pump, and, when drainage of the drainage reservoir is discharged to the outside from the external drainage circuit, controls the drainage pump using a corrected value of the flow rate error from immediately before initiating the discharging of drainage.
摘要:
Burdens on doctors and nurses are reduced in a blood purification therapy, and burdens on patients are also reduced while the cost reduction of the blood purification therapy is attained. A blood purification device 1 include a blood circuit 10 having two blood purifiers 20 and 21 parallelly connected thereto, switch means 11 capable of selectively supplying blood to the blood purifiers 20 and 21, and cleaning fluid supply means 12 capably of selectively supplying cleaning fluid to the blood purifiers 20 and 21. The cleaning fluid is supplied to the second blood purifier 21 while the blood is supplied to the first blood purifier 20, and the cleaning fluid is supplied to the first blood purifier 20 while the blood is supplied to the second blood purifier 21.
摘要:
Provided are a parvovirus derived from an unconcentrated cell culture supernatant, having a infectivity titer of 10 9 TCID 50 /mL or more and an {infectivity titer (TCID 50 /mL)}:{impurity protein concentration (ng/mL)} ratio more than 5000:1; and a method of producing such a high-infectivity titer and high-purity parvovirus.
摘要:
The present invention provides a filter element for a blood processing filter, comprising a nonwoven fabric, wherein the quantity of crystallization heat of the uncrystallized portion of the nonwoven fabric is 5 J/g or smaller before steam heat treatment.