公开(公告)号：EP2200966A1

公开(公告)日：2010-06-30

申请号：EP08837972.2

申请日：2008-10-10

Applicant: Lonza Ltd. ,  Lonza Guangzhou Research And Development Center Ltd

Inventor： BRIEDEN, Walter ,  MICHEL, Dominique ,  QUITTMANN, Wilhelm ,  RAINONE, Fabio ,  PAN, Jie-Hui ,  FANG, Hang-Bing ,  SONG, Ying-Xia

IPC: C07C201/02 ,  C07C201/12 ,  C07C203/04 ,  C07C205/57

CPC classification number: C07C201/02 ,  C07C201/12 ,  C07C203/04 ,  C07C205/57

Abstract: The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy residue, the latter being esterified with an acid other than nitric acid.

公开(公告)号：EP2170803A1

公开(公告)日：2010-04-07

申请号：EP08761150.5

申请日：2008-06-18

Applicant: Nicox S.A.

Inventor： HACK, Achim ,  WEINGARTNER, Gunter ,  KRAMER, Matthias

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C07C201/02 ,  C07C67/08 ,  C07C227/18 ,  C07C315/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/337 ,  C07D209/18 ,  C07D209/46 ,  C07D209/86 ,  C07D231/12 ,  C07D261/08 ,  C07D313/14 ,  C07D333/24 ,  C07D337/14 ,  C07D487/04 ,  C07D491/04 ,  C07C69/003 ,  C07C317/44 ,  C07C229/42 ,  C07C69/28 ,  C07C203/04

Abstract: The present invention relates to a process for the preparation of 1,4-butanediol mononitrate as intermediate for large scale preparation of high purity nitrooxybutyl ester of pharmaceutically active compounds.

Abstract translation: 本发明涉及一种制备1,4-丁二醇单硝酸酯作为大规模制备药学活性化合物的高纯度硝基氧丁基酯的中间体的方法。

公开(公告)号：EP1532098B1

公开(公告)日：2009-11-18

申请号：EP03747879.9

申请日：2003-08-06

Applicant: NicOx S.A.

Inventor： DEL SOLDATO, Piero ,  SANTUS, Giancarlo ,  BENEDINI, Francesca

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C07C269/06 ,  C07C67/10 ,  C07C69/734 ,  C07C201/02 ,  C07C203/04 ,  C07C271/28 ,  C07C303/28 ,  C07C309/73

公开(公告)号：EP2050810A2

公开(公告)日：2009-04-22

申请号：EP08253369.6

申请日：2008-10-17

Applicant: Petroleo Brasileiro S.A. Petrobras

Inventor： Rabello, Carlos Rene Klotz ,  Siqueira, Bernardo Galvâo ,  De Menezes, Raphael Bezerra

IPC: C10L1/23 ,  C10L10/12 ,  C07C201/02 ,  C07C203/04

CPC classification number: C10L10/12 ,  C07C205/50 ,  C10L1/231

Abstract: A method is presented for production of a cetane-index improvement additive for diesel oil produced from biodiesel from castor bean oil.
Said method employs nitration at the site of the hydroxyl functionality already forming part of the natural molecular chemical structure of the fatty acid ester generated in the production of biodiesel obtained from castor bean oil.
The present method is advantageous through having a lower number of processing stages, lower rate of undesired nitration of unsaturations, lower consumption of nitrating mixture, reduction in the level of attachment of NO 2 to the molecules of the additive and consequent reduction in undesirable environmental impacts caused by NO x , and utilising a raw material from a renewable source.
The present cetane improvement additive may be employed as an additive to diesel oil of mineral origin, biodiesel, or synergetic mixtures thereof in any proportion.

Abstract translation: 提出了一种用于生产由蓖麻油生产的生物柴油的柴油十六烷指数改进添加剂的方法。 所述方法在已经形成在由蓖麻油获得的生物柴油的生产中产生的脂肪酸酯的天然分子化学结构的一部分的羟基官能团的位置处进行硝化。 本方法通过具有较少数量的处理阶段，较低的不希望的不饱和硝化速率，较低的硝化混合物的消耗，降低NO 2与添加剂分子的水平以及随之而来的减少不期望的环境影响是有利的 由NO x引起，并利用可再生能源的原料。 本十六烷改进添加剂可以以任何比例用作矿物来源的柴油，生物柴油或其协同混合物的添加剂。

公开(公告)号：EP2048129A1

公开(公告)日：2009-04-15

申请号：EP07020022.5

申请日：2007-10-12

Applicant: Lonza AG

Inventor： The designation of the inventor has not yet been filed

IPC: C07C201/02 ,  C07C201/12 ,  C07C203/04 ,  C07C205/57

CPC classification number: C07C201/02 ,  C07C201/12 ,  C07C203/04 ,  C07C205/57

Abstract: The present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one hydroxy group, wherein the at least one hydroxy group may be present in form of an esterified hydroxy residue, the latter being esterified with an acid other than nitric acid.

Abstract translation: 本发明涉及一种制备具有至少一个硝基氧基和至少一个羟基的有机硝酸盐的方法，其中至少一个羟基可以以酯化的羟基残基的形式存在，后者用酸酯化 硝酸除外。

公开(公告)号：EP1560805A1

公开(公告)日：2005-08-10

申请号：EP03778304.0

申请日：2003-11-06

Applicant: Dipharma S.p.A.

Inventor： SCUBLA, Tiziano ,  FRANCESCUTTI, Nevio ,  GORASSINI, Fausto ,  CASTALDI, Graziano

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C07C203/04 ,  C07C201/02

Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.

公开(公告)号：EP1560804A1

公开(公告)日：2005-08-10

申请号：EP03772310.3

申请日：2003-11-06

Applicant: Dipharma S.p.A.

Inventor： FRANCESCUTTI, Nevio ,  SCUBLA, Tiziano ,  GORASSINI, Fausto ,  CASTALDI, Graziano

IPC: C07C201/02 ,  C07C203/04 ,  C01B21/46

CPC classification number: C01B21/46 ,  C07C201/02 ,  C07C203/04

Abstract: A process for the preparation of compounds of formula: HO-A-ONO2 (I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with 'stabilised' nitric acid is herein disclosed. The process is safer to operators and allows to obtain advantageous yields on an industrial scale.

公开(公告)号：EP1194397B1

公开(公告)日：2004-09-22

申请号：EP00942111.6

申请日：2000-06-21

Applicant: Nicox S.A.

Inventor： CASTALDI, Graziano ,  OLDANI, Erminio ,  RAZZETTI, Gabriele ,  BENEDINI, Francesca

IPC: C07C203/04 ,  C07C201/02 ,  C07C67/14 ,  C07C69/90

CPC classification number: C07C67/14 ,  C07C201/02 ,  C07C69/86 ,  C07C203/04

Abstract: A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives of formula (I) wherein R1 is the OCOR3 group characterized in that it comprises the following steps: a) reaction of a halide of a salicylic acid derivative with hydroxybenzylalcohol in the presence of a base; b) nitration of the obtained product in anhydrous conditions by a mixture of nitric acid with a different inorganic acid, or an organic acid, or an anhydride of one or two organic acids; c) recovery of the final product.

公开(公告)号：EP1194397A1

公开(公告)日：2002-04-10

申请号：EP00942111.6

申请日：2000-06-21

Applicant: NICOX S.A.

Inventor： CASTALDI, Graziano ,  OLDANI, Erminio ,  RAZZETTI, Gabriele ,  BENEDINI, Francesca

IPC: C07C203/04 ,  C07C201/02 ,  C07C67/14 ,  C07C69/90

CPC classification number: C07C67/14 ,  C07C201/02 ,  C07C69/86 ,  C07C203/04

Abstract: A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives of formula (I) wherein R1 is the OCOR3 group characterized in that it comprises the following steps: a) reaction of a halide of a salicylic acid derivative with hydroxybenzylalcohol in the presence of a base; b) nitration of the obtained product in anhydrous conditions by a mixture of nitric acid with a different inorganic acid, or an organic acid, or an anhydride of one or two organic acids; c) recovery of the final product.

公开(公告)号：EP1038862A2

公开(公告)日：2000-09-27

申请号：EP00105136.6

申请日：2000-03-10

Applicant: Dinamite Dipharma S.p.A.

Inventor： Beltrame, Andrea ,  Scubla, Tiziano

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07D493/04 ,  C07C203/04

Abstract: A process for the preparation of nitric monoesters of dihydroxyalkyl, dihydroxycycloalkyl or dihydroxy(poly)cycloalkyl compounds starting from the respective nitric diesters of dihydroxyalkyl, dihydroxycycloalkyl or dihydroxy(poly)cycloalkyl compounds, which comprises the hydrogenation of the nitric diesters with a platinum (0) catalyst.

Abstract translation: 从二羟基烷基，二羟基环烷基或二羟基（多）环烷基化合物的相应硝酸二酯开始制备二羟基烷基，二羟基环烷基或二羟基（聚）环烷基化合物的硝酸单酯的方法，其包括用铂（0 ）催化剂。