公开(公告)号：EP4330223A1

公开(公告)日：2024-03-06

申请号：EP22724186.6

申请日：2022-04-28

Applicant: FMC CORPORATION ,  FMC Agro Singapore Pte. Ltd.

Inventor： CORBETT, Richard, M. ,  BALDYCHEV, Ivan, Sergeyevich ,  SHAPIRO, Rafael ,  STAUFFER, Christina, S.

IPC: C07C227/04 ,  C07C229/56 ,  C07C231/12 ,  C07C233/65 ,  C07C201/12 ,  C07C205/57

公开(公告)号：EP2547645B1

公开(公告)日：2018-07-04

申请号：EP11709692.5

申请日：2011-03-16

Applicant: Janssen Pharmaceuticals, Inc.

Inventor： ORMEROD, Dominic, John ,  DEPRÉ, Dominique, Paul, Michel ,  HORVATH, Andras

IPC: C07C67/03 ,  C07C67/31 ,  C07C255/57 ,  C07D309/30 ,  C07C69/757 ,  C07C201/12 ,  C07C205/57 ,  C07C235/40 ,  C07C317/44 ,  C07C215/30 ,  C07D417/04 ,  C07D417/14 ,  C07C231/12 ,  C07D251/30 ,  C07D251/28 ,  C07D491/18 ,  C07C51/02 ,  C07C51/41 ,  C07C215/20

CPC classification number: C07D417/04 ,  C07B2200/07 ,  C07C51/02 ,  C07C51/412 ,  C07C51/43 ,  C07C61/06 ,  C07C67/03 ,  C07C67/31 ,  C07C69/757 ,  C07C201/12 ,  C07C205/57 ,  C07C215/20 ,  C07C215/30 ,  C07C231/12 ,  C07C235/40 ,  C07C235/82 ,  C07C255/57 ,  C07C317/44 ,  C07C2601/08 ,  C07D251/28 ,  C07D251/30 ,  C07D309/30 ,  C07D417/14 ,  C07D491/18 ,  C07D491/22 ,  C07C62/24

Abstract: A process for preparing [(1 R ,2 R )-4-oxo-1,2-cyclopentanedicarboxylic acid II, by the resolution of racemic 4-oxo-1,2-cyclopentanedicarboxylic acid (V), said process comprising: (a) reacting 4-oxo-1,2-cyclopentanedicarboxylic acid (V) with brucine or ( 1R,2S )-(-)-ephedrine, thus preparing the bis-brucine or bis-( 1R , 2S )-(-)-ephedrine salt of (V), and (b) precipitating selectively the bis-brucine or bis-( 1R,2S )-( - )-ephedrine salt of (1 R ,2 R )-4-oxo-1,2-cyclopentanedicarboxylic acid II, while the bis-brucine or bis-( 1R,2S ) - (-)-ephedrine salt of [(1 S ,2 S )-4-oxo-1,2-cyclopentanedicarboxylic acid stays in solution; (c) liberating the acid II by removal of brucine or ( 1R , 2S )-(-)-ephedrine from the precipitated salt obtained in step (b).

公开(公告)号：EP2928858B1

公开(公告)日：2018-01-31

申请号：EP13812336.9

申请日：2013-12-06

Applicant: Cayman Chemical Company, Incorporated

Inventor： HERING, Kirk William ,  CHAMBOURNIER, Gilles ,  ENDRES, Gregory William ,  FEDIJ, Victor ,  KRELL, Thomas James, II ,  MAHMOUD, Hussein Mahmoud

IPC: C07C205/57 ,  C07D301/32 ,  C07F7/18 ,  C07C51/347

CPC classification number: C07C51/347 ,  C07C41/26 ,  C07C41/44 ,  C07C45/29 ,  C07C51/09 ,  C07C51/412 ,  C07C205/57 ,  C07C2603/14 ,  C07D301/00 ,  C07D301/32 ,  C07D303/14 ,  C07D303/16 ,  C07D317/22 ,  C07F7/1804 ,  C07C59/72 ,  C07C43/23

Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.

公开(公告)号：EP1375465A4

公开(公告)日：2006-01-11

申请号：EP02708747

申请日：2002-04-01

Applicant: EISAI CO LTD

Inventor： EGUCHI YOSHIHITO ,  CHIBA KEN-ICHI ,  GOTO MASAKI ,  OBAISHI HIROSHI ,  KUBOI YOSHIKAZU

IPC: A61K31/12 ,  A61K31/235 ,  A61K31/24 ,  A61K31/4402 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P13/12 ,  A61P17/00 ,  A61P19/02 ,  A61P27/02 ,  A61P29/00 ,  A61P43/00 ,  C07C49/657 ,  C07C49/747 ,  C07C49/753 ,  C07C205/57 ,  C07D207/12 ,  C07D401/04 ,  C07D453/02 ,  C07C49/413 ,  C07C49/503 ,  C07C49/517 ,  C07C49/717 ,  C07C49/84 ,  C07C69/76 ,  C07C205/60 ,  C07D213/16

CPC classification number: C07D401/04 ,  A61K31/12 ,  A61K31/235 ,  A61K31/24 ,  A61K31/4402 ,  C07C49/657 ,  C07C49/747 ,  C07C49/753 ,  C07C205/57 ,  C07D207/12 ,  C07D453/02

Abstract: A compound which has cytokine production inhibitory activity and is useful for the treatment of diseases in which cytokine participates. The compound is represented by the following general formula (I) [wherein A represents an optionally substituted cyclic compound group; the partial structure -D---E- represents -CH2CH2- or -CH=CH-; W represents -CH2-, -CH2CH2-, -CH=CH-, or -CH=; the partial structure >X---Y- represents >CH-(CH2)n-, >C=CH-, >CH-CH2-CH(OH)-, >CH-CH2-C(=O)-, >CH-O-, or >CH-O-CO-, provided that when W is -CH=, then X---Y- represents C-(CH2)p-; Z represents a divalent aliphatic hydrocarbon group; R?1 and R2¿ are the same or different and each represents hydrogen, hydroxy, alkoxy, or alkoxyalkoxy; and m is 0 or 1]. (I)

Abstract translation: 具有细胞因子产生抑制活性并可用于治疗细胞因子参与的疾病的化合物。 该化合物由以下通式（I）表示[其中A表示任选取代的环状化合物基团; 部分结构-D --- E-表示-CH 2 CH 2 - 或-CH = CH-; W表示-CH 2 - ， - CH 2 CH 2 - ， - CH = CH-或-CH = 部分结构> X-Y-表示> CH-（CH 2）n - >C≡CH-> CH-CH 2 -CH（OH） - > CH-CH 2 -C（= O） - > CH-O-或> CH-O-CO-，条件是当W为-CH =时，则X --- Y-表示C-（CH 2）p - Z表示二价脂族烃基; R 1和R 2'相同或不同，各自代表氢，羟基，烷氧基或烷氧基烷氧基; 和m是0或1]。 （一世）

公开(公告)号：EP1361873A4

公开(公告)日：2005-10-26

申请号：EP02710275

申请日：2002-02-13

Applicant: WARNER LAMBERT CO

Inventor： ANDRIANJARA CHARLES ,  ORTWINE DANIEL FRED ,  PAVLOVSKY ALEXANDER GREGORY ,  ROARK WILLIAM HOWARD

IPC: C07D239/90 ,  A61K31/00 ,  A61K31/36 ,  A61K31/444 ,  A61K31/517 ,  A61K31/519 ,  A61P1/02 ,  A61P1/04 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P17/06 ,  A61P19/00 ,  A61P19/02 ,  A61P19/10 ,  A61P21/04 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07C69/76 ,  C07C69/92 ,  C07C205/57 ,  C07C229/62 ,  C07C235/60 ,  C07D213/30 ,  C07D213/40 ,  C07D239/96 ,  C07D285/14 ,  C07D285/24 ,  C07D285/32 ,  C07D317/54 ,  C07D317/58 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  A61P9/00

CPC classification number: C07D471/04 ,  A61K31/00 ,  C07C235/60 ,  C07D213/30 ,  C07D213/40 ,  C07D239/96 ,  C07D285/14 ,  C07D285/24 ,  C07D285/32 ,  C07D317/54 ,  C07D317/58 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

公开(公告)号：EP1435894A4

公开(公告)日：2005-07-06

申请号：EP02750281

申请日：2002-07-23

Applicant: GALILEO PHARMACEUTICALS INC

Inventor： WANG BING ,  ZHANG YONG-KANG ,  CHEN JIAN ,  ZHANG WEI ,  SONG JIANGAO ,  DEL BALZO UGHETTA ,  BROWN LESLEY ,  MILLER GUY ,  BODDUPALLI SEKHAR ,  BOBZIN STEVEN ,  GILAT SYLVAIN

IPC: C07D295/18 ,  A61K8/00 ,  A61K8/30 ,  A61K31/05 ,  A61K31/055 ,  A61K31/06 ,  A61K31/085 ,  A61K31/09 ,  A61K31/10 ,  A61K31/122 ,  A61K31/15 ,  A61K31/166 ,  A61K31/18 ,  A61K31/192 ,  A61K31/21 ,  A61K31/235 ,  A61K31/277 ,  A61K31/28 ,  A61K31/30 ,  A61K31/315 ,  A61K31/343 ,  A61K31/353 ,  A61K31/36 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/4425 ,  A61K31/444 ,  A61K31/4453 ,  A61K31/5375 ,  A61K31/555 ,  A61K31/662 ,  A61K31/7024 ,  A61K33/32 ,  A61P1/04 ,  A61P3/10 ,  A61P5/24 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P17/10 ,  A61P17/16 ,  A61P19/02 ,  A61P21/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P37/06 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/02 ,  C07C39/21 ,  C07C39/373 ,  C07C39/44 ,  C07C43/215 ,  C07C43/23 ,  C07C45/30 ,  C07C45/71 ,  C07C49/737 ,  C07C49/747 ,  C07C50/34 ,  C07C69/007 ,  C07C69/76 ,  C07C69/94 ,  C07C205/17 ,  C07C205/20 ,  C07C205/22 ,  C07C205/35 ,  C07C205/57 ,  C07C235/42 ,  C07C255/15 ,  C07C255/36 ,  C07C255/53 ,  C07C255/54 ,  C07C311/29 ,  C07C317/22 ,  C07D213/30 ,  C07D213/53 ,  C07D231/22 ,  C07D231/26 ,  C07D233/24 ,  C07D233/64 ,  C07D235/08 ,  C07D277/20 ,  C07D277/24 ,  C07D277/30 ,  C07D277/34 ,  C07D295/22 ,  C07D295/26 ,  C07D307/83 ,  C07D311/72 ,  C07D317/62 ,  C07D333/16 ,  C07F1/08 ,  C07F9/40 ,  C07H13/08 ,  A61K31/185 ,  A61K31/075

CPC classification number: C07D213/30 ,  C07C43/23 ,  C07C45/30 ,  C07C45/71 ,  C07C49/737 ,  C07C69/94 ,  C07C205/17 ,  C07C205/20 ,  C07C205/22 ,  C07C205/35 ,  C07C205/57 ,  C07C235/42 ,  C07C255/36 ,  C07C311/29 ,  C07C2603/24 ,  C07D213/53 ,  C07D231/26 ,  C07D277/20 ,  C07D277/24 ,  C07D295/26 ,  C07D311/72 ,  C07F9/4021 ,  C07C47/575

公开(公告)号：EP1042305B1

公开(公告)日：2005-06-08

申请号：EP98964221.0

申请日：1998-12-22

Applicant: Bayer Pharmaceuticals Corp.

Inventor： MILLER, Scott ,  OSTERHOUT, Martin ,  DUMAS, Jacques ,  KHIRE, Uday ,  LOWINGER, Timothy, Bruno ,  RIEDL, Bernd ,  SCOTT, William, J. ,  SMITH, Roger, A. ,  WOOD, Jill, E. ,  GUNN, David ,  HATOUM-MOKDAD, Holia ,  RODRIGUEZ, Mareli ,  SIBLEY, Robert ,  WANG, Ming ,  TURNER, Tiffany ,  BRENNAN, Catherine

IPC: C07D273/00 ,  C07D275/00 ,  A61K31/17 ,  C07D333/20 ,  C07D233/70 ,  C07D213/70 ,  C07D209/88 ,  C07C317/42 ,  C07C275/36 ,  C07C205/57 ,  A61K31/44 ,  A61K31/535 ,  A61K31/425 ,  A61K31/40 ,  C07D207/26 ,  C07D207/40 ,  C07D213/53 ,  C07D231/08 ,  C07D277/68 ,  C07D209/76 ,  C07D213/68 ,  C07D233/22 ,  C07D307/20 ,  C07C275/34 ,  C07C311/48

CPC classification number: C07D207/27 ,  A61K31/17 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/535 ,  A61K31/5375 ,  C07C205/11 ,  C07C205/22 ,  C07C205/37 ,  C07C205/38 ,  C07C205/57 ,  C07C205/58 ,  C07C275/30 ,  C07C275/34 ,  C07C275/36 ,  C07C275/40 ,  C07C275/42 ,  C07C309/88 ,  C07C311/48 ,  C07C317/42 ,  C07D207/26 ,  C07D207/404 ,  C07D209/76 ,  C07D209/86 ,  C07D209/88 ,  C07D213/40 ,  C07D213/53 ,  C07D213/68 ,  C07D213/70 ,  C07D231/08 ,  C07D233/22 ,  C07D233/70 ,  C07D263/58 ,  C07D277/68 ,  C07D295/185 ,  C07D307/20 ,  C07D333/20 ,  C07D409/12 ,  Y02A50/411

Abstract: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.

公开(公告)号：EP1169295A1

公开(公告)日：2002-01-09

申请号：EP00916323.9

申请日：2000-03-15

Applicant: EASTMAN CHEMICAL COMPANY

Inventor： BOAZ, Neil, W. ,  COLEMAN, M., Todd ,  HIGHTOWER, Timothy, R.

IPC: C07C205/57 ,  C07C319/14

CPC classification number: C07C205/57 ,  C07C201/12 ,  C07C319/14 ,  C07C2601/02 ,  C07C323/62

Abstract: Methods for preparing substituted aromatic carboxylic acid esters are described. In particular, the invention relates a method for preparing a nitro-substituted aromatic carboxylic acid ester of Formula (A). Additionally the invention relates to a method for preparing a thioether-substituted aromatic carboxylic acid ester of Scheme (B). Such aryl esters are useful in the preparation of various agrochemicals and agrochemical intermediates.

Abstract translation: 描述了制备取代的芳族羧酸酯的方法。 特别地，本发明涉及制备式（A）的硝基取代的芳族羧酸酯的方法。 另外，本发明涉及制备方案（B）的硫醚取代的芳族羧酸酯的方法。 这样的芳基酯可用于制备各种农用化学品和农业化学中间体。

公开(公告)号：EP0763009A4

公开(公告)日：1998-05-06

申请号：EP95921230

申请日：1995-05-11

Applicant: UNIV BOSTON

Inventor： ROTHSCHILD KENNETH J ,  SONAR SANJAY M ,  OLEJNIK JERZY

IPC: A61K38/00 ,  A61K41/00 ,  C07C205/45 ,  C07C205/57 ,  C07D207/40 ,  C07D207/404 ,  C07D311/16 ,  C07D405/12 ,  C07D495/04 ,  C07H19/04 ,  C07H21/00 ,  C07K1/107 ,  C07K1/13 ,  C12P21/00 ,  G01N33/532 ,  C07C205/00 ,  C07C205/06 ,  C07C205/07 ,  C07D235/02 ,  C07H1/06 ,  C07H1/08

CPC classification number: C12Q1/6876 ,  A61K38/00 ,  A61K41/0042 ,  C07C205/45 ,  C07C205/57 ,  C07D207/404 ,  C07D311/16 ,  C07D405/12 ,  C07D495/04 ,  C07H19/04 ,  C07H21/00 ,  C07K1/1077 ,  C07K1/13 ,  C12P21/00 ,  G01N33/532

Abstract: The present invention relates to a bioreactive agent comprising a detectable moiety linked to a photo-reactive moiety, wherein said photoreactive moiety comprises at least one group covalently bound to a substrate to form a conjugate that can be selectively photocleaved to release said substrate, wherein said substrate is selected from proteins, peptides, amino acids, lipids, cells, virus particles, fatty acids, nucleic acids, nucleotides, nucleosides, oligonucleotides, polysaccharides and inorganic molecules.

公开(公告)号：EP0662999A4

公开(公告)日：1995-12-13

申请号：EP94924095

申请日：1994-07-27

Applicant: CHEVRON CHEM CO

Inventor： CHERPECK RICHARD E

IPC: C07C69/78 ,  C07C205/57 ,  C07C205/59 ,  C07C229/54 ,  C07C229/60 ,  C07C229/64 ,  C08G65/32 ,  C10L1/182 ,  C10L1/183 ,  C10L1/192 ,  C10L1/195 ,  C10L1/238 ,  F02B3/06 ,  C10L1/18 ,  C07C229/00

CPC classification number: C10L1/238 ,  C07C69/78 ,  C07C205/57 ,  C07C205/59 ,  C07C229/60 ,  C07C229/64 ,  F02B3/06

Abstract: Fuel compositions containing a major amount of hydrocarbons boiling in the gasoline or diesel range and an effective deposit-controlling amount of a poly(oxyalkylene) aromatic ester having formula (I) where A1 is nitro, amino, N-alkylamino wherein the alkyl group contains 1 to 6 carbon atoms, or N,N-dialkylamino wherein each alkyl group independently contains 1 to 6 carbon atoms; R1 and R2 are independently hydrogen, hydroxy, lower alkyl, or lower alkoxy; R3 and R4 are independently hydrogen or lower alkyl, and each R3 and R4 is independently selected in each -O-CHR3-CHR4- unit; R5 is hydrogen, alkyl having 1 to 100 carbon atoms, phenyl, aralkyl having 7 to 100 carbon atoms or alkaryl having 7 to 100 carbon atoms, or an acyl group of formula (a) or (b) where R6 is alkyl having 1 to 30 carbon atoms, phenyl, aralkyl having 7 to 36 carbon atoms or alkaryl having 7 to 36 carbon atoms; R7 and R8 are independently hydrogen, hydroxy, lower alkyl, or lower alkoxy; A2 is a nitro, amino, N-alkylamino wherein the alkyl group contains 1 to 6 carbon atoms, or N,N-dialkylamino wherein each alkyl group independently contains 1 to 6 carbon atoms; n is an integer from 5 to 100; and x and y are each independently integers from 0 to 10.