公开(公告)号：EP1284972A1

公开(公告)日：2003-02-26

申请号：EP01939054.1

申请日：2001-05-16

申请人： COR THERAPEUTICS, INC.

发明人： SCARBOROUGH, Robert ,  KALARITIS, Panos ,  STEENROD, J., Guy ,  YIANNIKOUROS, George ,  CRUSKIE, Michael, P., Jr. ,  SHA, Dezhi

IPC分类号： C07D311/58

CPC分类号： C07D311/58

摘要： Disclosed are process steps and processes for producing chromane compounds, preferably 2-(6-amino-chroman-2yl) acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.

公开(公告)号：EP1257550A1

公开(公告)日：2002-11-20

申请号：EP01908817.8

申请日：2001-02-05

申请人： COR THERAPEUTICS, INC.

发明人： SCARBOROUGH, Robert, M. ,  JANTZEN, Hans-Michael ,  HUANG, Wolin ,  SEDLOCK, David, M. ,  MARLOWE, Charles, K.

IPC分类号： C07D417/12 ,  C07D411/12 ,  C07D417/14 ,  C07D401/04 ,  C07D239/22 ,  A61P9/00 ,  A61K31/40 ,  A61K31/38 ,  A61K31/44 ,  A61K31/495 ,  A61K31/425 ,  A61K31/55 ,  C07D521/00

CPC分类号： C07D239/22 ,  C07D239/48 ,  C07D239/50 ,  C07D333/34 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D495/04

摘要： Novel compounds of formula (I) to (VI), which more particularly include sulfonylura derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I)-(VI), or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP0788356B9

公开(公告)日：2002-10-02

申请号：EP95941340.2

申请日：1995-10-26

申请人： COR THERAPEUTICS, INC.

发明人： GIESE, Neill, A. ,  LOKKER, Nathalie

IPC分类号： A61K31/365

CPC分类号： A61K31/366 ,  A61K31/365

摘要： A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of formula (I) wherein R1 is H, lower alkyl, or lower alkanoyl; R2 is H, lower alkyl, or lower alkanoyl; R3 and R4 together represent a cis double bond or -O- or each of R3 and R4 independently represents H or OR; R5 is =O, =S, or -H, -OR; R6 and R7 together represent a double bond or -O- or each of R6 and R7 independently represents H or OR; R8 and R9 together represent a double bond or -O- or each of R8 and R9 independently represents H or OR; and each R independently represents H, lower alkyl, or lower alkanoyl.

公开(公告)号：EP0801574A4

公开(公告)日：2002-09-04

申请号：EP96936741

申请日：1996-10-18

申请人： COR THERAPEUTICS INC

发明人： PHILLIPS DAVID ,  LAW DEBBIE A ,  ALAIMO LISA N

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K45/00 ,  A61P7/02 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K14/705 ,  C12N5/06 ,  C12N11/02 ,  C12N15/09 ,  A61K39/00 ,  A01N37/18 ,  A61K39/38 ,  G01N33/574

CPC分类号： C07K14/70546

摘要： The present invention discloses that phosphorylation of cytoplasmic tyrosine residues in the β-subunit of integrins is needed for signal protein association. The invention provides methods of identifying signaling partners involved in integrin mediated signaling, methods of identifying agents which block integrin mediated signaling, methods of using agents which block intergrin mediated signaling to modulate biological and pathological processes, and agents which block integrin mediated signaling.

公开(公告)号：EP1224186A2

公开(公告)日：2002-07-24

申请号：EP00974002.8

申请日：2000-10-27

申请人： COR THERAPEUTICS, INC.

发明人： SCARBOROUGH, Robert, M. ,  MEHROTA, Mukund ,  PANDEY, Anjali ,  SMYTH, Mark

IPC分类号： C07D471/10 ,  A61K31/438 ,  A61P9/00 ,  C07D413/14 ,  C07D401/04

CPC分类号： C07D401/04 ,  C07D413/14 ,  C07D471/10

摘要： This invention relates to certain substituted or unsubstituted pyridyl-containing spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.

公开(公告)号：EP1185512A2

公开(公告)日：2002-03-13

申请号：EP00937704.5

申请日：2000-05-24

申请人： COR THERAPEUTICS, INC.

发明人： ZHU, Bing-Yan ,  SCARBOROUGH, Robert, M. ,  WANG, Lingyan

IPC分类号： C07D207/16 ,  C07D211/60 ,  C07C311/39 ,  C07D403/04 ,  C07D401/04 ,  C07D413/04 ,  C07D243/08 ,  C07D241/04 ,  A61P7/00 ,  A61K31/40

CPC分类号： C07D401/04 ,  C07C311/46 ,  C07D207/16 ,  C07D211/60 ,  C07D241/04 ,  C07D243/08 ,  C07D403/04 ,  C07D413/04

摘要： Compounds, e.g. described in claim 5, formula (I) and formula (II), where A-B is (1), their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：EP1185511A2

公开(公告)日：2002-03-13

申请号：EP00937698.9

申请日：2000-05-24

申请人： COR THERAPEUTICS, INC.

发明人： ZHU, Bing-Yan ,  SCARBOROUGH, Robert, M.

IPC分类号： C07D207/16 ,  C07D211/60 ,  C07C311/39 ,  C07D403/04 ,  C07D401/04 ,  C07D413/04 ,  C07D243/08 ,  C07D241/04 ,  A61P7/00 ,  A61K31/40

CPC分类号： C07D401/04 ,  C07C311/46 ,  C07D207/16 ,  C07D211/60 ,  C07D241/04 ,  C07D243/08 ,  C07D403/04 ,  C07D413/04

摘要： Compounds, e.g. described in Table (1), their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

摘要翻译： 化合物，例如 如表（1）所述，公开了它们的盐和与其相关的组合物具有抗哺乳动物因子Xa的活性。 这些化合物在体外或体内用于预防或治疗凝血障碍。

公开(公告)号：EP1185509A2

公开(公告)日：2002-03-13

申请号：EP00942640.4

申请日：2000-05-24

申请人： COR THERAPEUTICS, INC.

发明人： SU, Ting ,  ZHU, Bing-Yan ,  KANE-MAGUIRE, Kim ,  SCARBOROUGH, Robert, M. ,  ZHANG, Penglie

IPC分类号： C07C311/46 ,  C07D213/74 ,  A61K31/18 ,  A61K31/277 ,  A61K31/501 ,  A61P7/02

CPC分类号： C07D213/40 ,  C07C311/16 ,  C07C311/46 ,  C07D217/22 ,  C07D295/192 ,  C07D295/26 ,  C07D307/52 ,  C07D401/12

摘要： Compounds of the formula A - Y - D - E - G - J - Z - L in which D is a direct link, a substituted or unsubstituted phenyl or naphtyl group or a heterocyclic ring system; Z is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

摘要翻译： 式A-Y-D-E-G-J-Z-L的化合物，其中D为直接键，取代或未取代的苯基或萘基或杂环体系; Z是取代或未取代的苯基或萘基或杂环体系; 并且其它变量如权利要求中所定义，公开了它们的盐和与其相关的组合物具有针对哺乳动物因子Xa的活性。 这些化合物在体外或体内用于预防或治疗凝血障碍。

公开(公告)号：EP1185508A2

公开(公告)日：2002-03-13

申请号：EP00932732.1

申请日：2000-05-24

申请人： COR THERAPEUTICS, INC.

发明人： ZHU, Bing-Yan ,  ZHANG, Penglie ,  SCARBOROUGH, Robert, M.

IPC分类号： C07C311/16 ,  C07D213/40 ,  C07D333/20 ,  C07D217/22 ,  C07D401/12 ,  A61K31/18 ,  A61K31/33 ,  A61P7/02

CPC分类号： C07D213/40 ,  C07C311/16 ,  C07C311/46 ,  C07D217/22 ,  C07D295/192 ,  C07D295/26 ,  C07D307/52 ,  C07D401/12

摘要： Compounds of the formula A - Y - D - E - G - J - Z - L in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system and the other variables are as defined in the claims, their salts and other derivatives and compositions relating thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

摘要翻译： 式A-Y-D-E-G-J-Z-L的化合物，其中D为直接键，取代或未取代的苯基或萘基或杂环体系，其它变量如权利要求中所定义 公开了它们的盐和其它衍生物及其组合物具有抗哺乳动物因子Xa的活性。 这些化合物在体外或体内用于预防或治疗凝血障碍。

公开(公告)号：EP1183235A2

公开(公告)日：2002-03-06

申请号：EP00937700.3

申请日：2000-05-24

申请人： COR THERAPEUTICS, INC.

发明人： SU, Ting ,  ZHU, Bing-Yan ,  KANE-MAGUIRE, Kim ,  SCARBOROUGH, Robert, M. ,  ZHANG, Penglie

IPC分类号： C07C311/46 ,  C07D213/74 ,  C07D295/18 ,  C07D207/16 ,  C07D205/04 ,  C07D207/22 ,  C07D295/26 ,  C07D295/22 ,  C07D233/68 ,  C07D207/32 ,  C07D231/12 ,  C07D217/22 ,  A61K31/18 ,  A61K31/33 ,  A61P7/02

CPC分类号： C07D213/40 ,  C07C311/16 ,  C07C311/46 ,  C07D217/22 ,  C07D295/192 ,  C07D295/26 ,  C07D307/52 ,  C07D401/12

摘要： Compounds of formula A - Y - D - E - G - J - Z - L in which D is direct link, a substutited or unsubstituted phenyl or napththyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions relating thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.