公开(公告)号：EP0788356A2

公开(公告)日：1997-08-13

申请号：EP95941340.0

申请日：1995-10-26

申请人： COR THERAPEUTICS, INC.

发明人： GIESE, Neill, A. ,  LOKKER, Nathalie

IPC分类号： C12N9 ,  A61K31 ,  A61P35 ,  C07D313

CPC分类号： A61K31/366 ,  A61K31/365

摘要： A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of formula (I) wherein R1 is H, lower alkyl, or lower alkanoyl; R2 is H, lower alkyl, or lower alkanoyl; R3 and R4 together represent a cis double bond or -O- or each of R3 and R4 independently represents H or OR; R5 is =O, =S, or -H, -OR; R6 and R7 together represent a double bond or -O- or each of R6 and R7 independently represents H or OR; R8 and R9 together represent a double bond or -O- or each of R8 and R9 independently represents H or OR; and each R independently represents H, lower alkyl, or lower alkanoyl.

公开(公告)号：EP0788356B9

公开(公告)日：2002-10-02

申请号：EP95941340.2

申请日：1995-10-26

申请人： COR THERAPEUTICS, INC.

发明人： GIESE, Neill, A. ,  LOKKER, Nathalie

IPC分类号： A61K31/365

CPC分类号： A61K31/366 ,  A61K31/365

摘要： A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of formula (I) wherein R1 is H, lower alkyl, or lower alkanoyl; R2 is H, lower alkyl, or lower alkanoyl; R3 and R4 together represent a cis double bond or -O- or each of R3 and R4 independently represents H or OR; R5 is =O, =S, or -H, -OR; R6 and R7 together represent a double bond or -O- or each of R6 and R7 independently represents H or OR; R8 and R9 together represent a double bond or -O- or each of R8 and R9 independently represents H or OR; and each R independently represents H, lower alkyl, or lower alkanoyl.

公开(公告)号：EP0788356B1

公开(公告)日：2001-12-12

申请号：EP95941340.2

申请日：1995-10-26

申请人： COR THERAPEUTICS, INC.

发明人： GIESE, Neill, A. ,  LOKKER, Nathalie

IPC分类号： A61K31/365

CPC分类号： A61K31/366 ,  A61K31/365

摘要： A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of formula (I) wherein R1 is H, lower alkyl, or lower alkanoyl; R2 is H, lower alkyl, or lower alkanoyl; R3 and R4 together represent a cis double bond or -O- or each of R3 and R4 independently represents H or OR; R5 is =O, =S, or -H, -OR; R6 and R7 together represent a double bond or -O- or each of R6 and R7 independently represents H or OR; R8 and R9 together represent a double bond or -O- or each of R8 and R9 independently represents H or OR; and each R independently represents H, lower alkyl, or lower alkanoyl.

公开(公告)号：EP0788358A2

公开(公告)日：1997-08-13

申请号：EP95939917.0

申请日：1995-11-09

申请人： COR THERAPEUTICS, INC.

发明人： GIESE, Neill A. ,  LOKKER, Nathalie ,  LAIBELMAN, Alan M. ,  SCARBOROUGH, Robert M.

IPC分类号： C07D231 ,  A61K31 ,  A61P43 ,  C07D401 ,  C07D405 ,  C07D409

CPC分类号： A61K31/455 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4439

摘要： A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a compound of formula (I), wherein: R1 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, polyaromatic, polyaromatic carbonyl, polyheteroaromatic or polyheteroaromatic carbonyl; R2 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, lower hydrocarboyl, 5- or 6-membered heterocyclic aromatic carbonyl, polyaromatic or polyheteroaromatic; R3 is H or lower alkyl; R5 is H, lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, halogen, or cyano; and R6 is H or lower hydrocarboyl.