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61.发明公开Treatment of T cell mediated autoimmune disorders 失效Behandlung von T-ZellvermitteltenAutoimmunstörungen
公开(公告)号：EP1161954A1
公开(公告)日：2001-12-12
申请号：EP01114411.0
申请日：1996-06-06
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
IPC分类号： A61K39/395 , A61P37/06
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505
摘要： Use of an antagonist of a receptor on a surface of a T cell which mediates contac dependent helper effector functions for the manufacture of a medicament for the treatment of a T cell mediated autoimmune disorder, which treatment comprises administering to a subject a therapeutically or prophylactically effective amount of the antagonist.
摘要翻译： 在T细胞表面上的受体拮抗剂的用途，其介导依赖于依赖性辅助效应子功能，用于制备用于治疗T细胞介导的自身免疫性疾病的药物，所述治疗包括向受试者施用治疗或预防有效的 量的拮抗剂。
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公开(公告)号：EP0831906A1
公开(公告)日：1998-04-01
申请号：EP96921309.0
申请日：1996-06-06
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505
摘要： Method for the treatment of multiple sclerosis and other T cell mediated autoimmune disorders is described. The method involves administering to a subject a therapeutically effective amount of an antagonist of a receptor on a surface of a T cell which mediates contact dependent helper effector functions, for example, an anti-gp39 antibody.
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63.发明公开
公开(公告)号：EP0788512A1
公开(公告)日：1997-08-13
申请号：EP95926642.0
申请日：1995-07-07
CPC分类号： C07K14/70539 , A61K38/00 , C07K14/62 , G01N33/5091 , G01N2333/62
摘要： Proinsulin peptide compounds that modulate an immunological response by T cells of Type I diabetic subjects are disclosed. The proinsulin peptide compounds of the invention are preferably derived from a region of proinsulin that spans the junction between the B chain and C peptide of proinsulin. Pharmaceutical compositions comprising the proinsulin peptide compounds are also disclosed. An immunological response to a proinsulin peptide compound of the invention can be used as an indicator of Type I diabetes in a subject. Accordingly, the invention provides diagnostic assays for Type I diabetes using the proinsulin peptide compounds. Methods for inhibiting the development or progression of Type I diabetes in a subject by administering a proinsulin peptide compound are also disclosed.
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公开(公告)号：EP4240409A1
公开(公告)日：2023-09-13
申请号：EP21890045.4
申请日：2021-11-04
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65.发明公开
公开(公告)号：EP4217378A1
公开(公告)日：2023-08-02
申请号：EP21878500.4
申请日：2021-10-07
发明人： WANG, Yue , WHITFIELD, Michael L.
IPC分类号： C07K14/71 , A61P3/00 , C12Q1/6883
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公开(公告)号：EP4065160A1
公开(公告)日：2022-10-05
申请号：EP20895041.0
申请日：2020-12-02
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公开(公告)号：EP3904503A1
公开(公告)日：2021-11-03
申请号：EP21158803.3
申请日：2013-04-30
发明人： SENTMAN, Charles L
IPC分类号： C12N5/00
摘要： The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.
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公开(公告)号：EP3442579A2
公开(公告)日：2019-02-20
申请号：EP17783330.8
申请日：2017-04-14
发明人： MOLLOY, Michael , ROTHSTEIN, Jay , CARRIERE, Catherine , NOELLE, Randolph, J. , DELONG, Sabrina , LEMERCIER, Isabelle
IPC分类号： A61K39/395 , A61K45/06 , C07K16/28 , C07K16/30
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