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    IDENTIFICATION OF VSIG8 AS THE PUTATIVE VISTA RECEPTOR AND ITS USE THEREOF TO PRODUCE VISTA/VSIG8 MODULATORS
    2.
    发明公开
    IDENTIFICATION OF VSIG8 AS THE PUTATIVE VISTA RECEPTOR AND ITS USE THEREOF TO PRODUCE VISTA/VSIG8 MODULATORS 审中-公开
    鉴定VSIG8作为对照VISTA受体及其用于制备VISTA / VSIG8调节剂的用途

    公开(公告)号：EP3226900A1

    公开(公告)日：2017-10-11

    申请号：EP15865129.9

    申请日：2015-12-05

    申请人： Immunext, Inc.

    发明人： MOLLOY, Michael ,  GUO, Yalin ,  ROTHSTEIN, Jay ,  ROSENZWEIG, Michael

    IPC分类号： A61K39/395 ,  C07K16/46 ,  A61K38/16

    CPC分类号： C07K16/42 ,  A61K39/0011 ,  A61K2039/505 ,  C07K14/70503 ,  C07K16/2803 ,  C07K16/2827 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/531 ,  G01N33/57492

    摘要： The receptor for VISTA is identified (VSIG8) as well as the use of this receptor in the identification or synthesis of agonist or antagonist compounds, preferably antibodies, polypeptides and fusion proteins which agonize or antagonize the effects of VSIG8 and/or VISTA and/or the VSIG8/VISTA binding interaction. These antagonists may be used to suppress VISTA's suppressive effects on T cell immunity, and more particularly used in the treatment of cancer, or infectious disease. These agonist compounds may be used to potentiate or enhance VISTA's suppressive effects on T cell immunity and thereby suppress T cell immunity, such as in the treatment of autoimmunity, allergy or inflammatory conditions. Screening assays for identifying these agonists and antagonist compounds are also provided.

    摘要翻译： 鉴定VISTA受体（VSIG8）以及使用该受体鉴定或合成激动剂或拮抗剂化合物，优选抗体，多肽和融合蛋白，其激动或拮抗VSIG8和/或VISTA的作用和/或 VSIG8 / VISTA绑定交互。 这些拮抗剂可用于抑制VISTA对T细胞免疫的抑制作用，并且更特别用于治疗癌症或传染病。 这些激动剂化合物可用于增强或增强VISTA对T细胞免疫的抑制作用，从而抑制T细胞免疫，例如治疗自身免疫，变态反应或炎性病症。 还提供了用于鉴定这些激动剂和拮抗剂化合物的筛选测定法。