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61.发明公开
公开(公告)号：EP3440095A1
公开(公告)日：2019-02-13
申请号：EP17716173.4
申请日：2017-04-05
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公开(公告)号：EP3426281A1
公开(公告)日：2019-01-16
申请号：EP17709931.4
申请日：2017-03-02
发明人： MAHR, Andrea , WEINSCHENK, Toni , SONG, Colette , SCHOOR, Oliver , FRITSCHE, Jens , SINGH, Harpreet
IPC分类号： A61K38/17 , A61K39/00 , C07K7/06 , C12N5/0783
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63.发明公开
公开(公告)号：EP3423085A1
公开(公告)日：2019-01-09
申请号：EP17707843.3
申请日：2017-02-28
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64.发明公开NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST OVARIAN CANCER AND OTHER CANCERS 审中-公开用于免疫卵巢癌和其他癌症的新型肽和肽的组合
公开(公告)号：EP3317296A2
公开(公告)日：2018-05-09
申请号：EP16733523.1
申请日：2016-06-29
发明人： MAHR, Andrea , WEINSCHENK, Toni , HÖRZER, Helen , SCHOOR, Oliver , FRITSCHE, Jens , SINGH, Harpreet
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号：EP3066115A2
公开(公告)日：2016-09-14
申请号：EP14792834.5
申请日：2014-11-03
发明人： WEINSCHENK, Toni , FRITSCHE, Jens , WALTER, Steffen , HILF, Norbert , SCHORR, Oliver , SINGH, Harpreet , KUTTRUFF-COQUI, Sabrina , SONG, Colette
CPC分类号： A61K39/0011 , A61K35/17 , A61K38/1764 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/4748 , C07K14/705 , C07K14/70539 , C07K16/2833 , C07K2319/33 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 特别地，本发明涉及癌症的免疫治疗。 本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。 本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的HLA I类和II类分子的肽序列及其变体。
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66.发明公开NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS, SUCH AS LUNG CANCER, INCLUDING NSCLC 审中-公开神经细胞免疫缺陷病毒（GEMEN），维生素E（VERSCHIEDENE TUMOREN WIE LUNGENKREBS，EINSCHLIESSLICH NSCLC）
公开(公告)号：EP3030255A1
公开(公告)日：2016-06-15
申请号：EP14750175.3
申请日：2014-08-04
IPC分类号： A61K38/17 , A61K39/00 , C07K7/06 , C12N5/0783
CPC分类号： A61K39/0011 , A61K38/1709 , A61K45/06 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/7051 , C12N5/0638 , C12N9/6491 , C12N2502/11 , C12Y304/24065
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to more than 70 novel peptide sequences and their variants derived from HLA class I and HLA class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译： 本发明涉及用于免疫治疗方法的肽，核酸和细胞。 特别地，本发明涉及癌症的免疫治疗。 本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。 本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的70多种新型肽序列及其衍生自人类肿瘤细胞的HLA I类和HLA II类分子的变体。
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67.发明公开NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING GASTROINTESTINAL AND GASTRIC CANCER 有权新型免疫疗法针对不同肿瘤，包括胃肠道和胃癌
公开(公告)号：EP2547354A2
公开(公告)日：2013-01-23
申请号：EP11711292.0
申请日：2011-03-15
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K39/0011 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , A61P35/00 , C07K7/06 , C07K2319/00 , G01N33/505
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 95 novel peptide sequences and their variants derived from HLA class I molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
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公开(公告)号：EP4014043A1
公开(公告)日：2022-06-22
申请号：EP20757269.4
申请日：2020-08-12
发明人： SCHUSTER, Heiko , HUTT, Meike , WEINSCHENK, Toni , BUNK, Sebastian , SCHOOR, Oliver , BACKERT, Linus , HOFMANN, Martin , FRITSCHE, Jens , UNVERDORBEN, Felix , SCHIMMACK, Gisela , SCHWÖRER, Florian
IPC分类号： G01N33/569
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69.发明公开
公开(公告)号：EP3919507A2
公开(公告)日：2021-12-08
申请号：EP21177102.7
申请日：2016-06-29
发明人： MAHR, Andrea , WEINSCHENK, Toni , HÖRZER, Helen , SCHOOR, Oliver , FRITSCHE, Jens , SINGH, Harpreet
摘要： Provided is a peptide of up to 30 amino acids comprising the amino acid sequence of SEQ ID NO: 217 or one of SEQ ID NOs: 1 to 10, 12 to 216 and 218 to 640. Provided are inter alia also a nucleic acid encoding such peptide, a host cell comprising the same, a T-cell receptor reactive with such peptide and an activated T lymphocyte recognizing a cell which presents such peptide. Provided is also the use of any of the above in cancer treatment.
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70.发明公开
公开(公告)号：EP3875467A3
公开(公告)日：2021-12-08
申请号：EP21162594.2
申请日：2016-11-29
发明人： MAHR, Andrea , WEINSCHENK, Toni , HÖRZER, Helen , SCHOOR, Oliver , FRITSCHE, Jens , SINGH, Harpreet
摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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