公开(公告)号：EP2275128B1

公开(公告)日：2013-10-16

申请号：EP10011328.1

申请日：2003-04-01

申请人： Ben Gurion University Of The Negev Research And Development Authority

发明人： Mizrachi Nebenzahl, Yaffa

IPC分类号： A61K39/09 ,  A61K39/00 ,  A61K39/385 ,  A61K39/02 ,  C07K1/00

CPC分类号： A61K39/092 ,  Y10S530/825

公开(公告)号：EP2575849A2

公开(公告)日：2013-04-10

申请号：EP11789349.5

申请日：2011-06-01

申请人： Ben-Gurion University Of The Negev Research And Development Authority

发明人： BRIK, Ashraf ,  KUMAR, Ajish ,  ERLICH, Leslie ,  SPASSER, Liat

IPC分类号： A61K38/00 ,  C07K5/00

CPC分类号： C07K1/04 ,  A61K47/62 ,  C07K1/026 ,  C07K1/1075

摘要： The present invention discloses a process for preparing ubiquinated peptide conjugates comprising a ubiquitin peptide residue UR attached at its C-terminus to a substrate peptide via a native isopeptide bond, this process comprising combining Native Chemical Ligation (NCL) and solid phase peptide synthesis (SPPS). Further are disclosed ubiquinated peptide conjugates containing a native isopeptide bond, as well as various uses thereof.

公开(公告)号：EP2575848A2

公开(公告)日：2013-04-10

申请号：EP11789344.6

申请日：2011-05-26

申请人： Ben-Gurion University of The Negev Research and Development Authority

发明人： DAVID, Ayelet ,  ASHKENASY, Gonen ,  SHAMAY, Yossi

IPC分类号： A61K38/00 ,  C07K1/00

CPC分类号： C07K9/001 ,  A61K47/32 ,  A61K47/64 ,  A61K49/0002 ,  A61K49/0056

摘要： The caged cell-penetrating peptide (cCPP) conjugates of this invention are ideal for intracellular delivery of a broad variety of cargoes including various nanoparticulate pharmaceutical carriers (liposomes, micelles, microparticles, nanoparticles, polymer-conjugates). The conjugates comprise a detectable agent or a therapeutic agent, and the conjugates provide a novel strategy for site-specific delivery of the same to appropriate tissues in the subject. Versatile application of the conjugates in diagnostics and imaging is described.

公开(公告)号：EP2533792A2

公开(公告)日：2012-12-19

申请号：EP11741975.4

申请日：2011-02-09

申请人： Ben-Gurion University Of The Negev Research And Development Authority

发明人： BRIK, Ashraf ,  HAJ-YAHYA, Mahmood ,  KUMAR, Ajish ,  ERLICH, Leslie ,  SPASSER, Liat

IPC分类号： A61K38/00

CPC分类号： C07K1/1077 ,  C07K1/1075 ,  C07K14/00 ,  C07K14/001 ,  C07K14/47

摘要： The present invention discloses latent thioester functionalities attached to the C-terminus of a first polypeptide, or a first fragment thereof having a Cys residue at its N-terminus, and a process using this functionality for the preparation of polypeptide thioesters, in particular of ubiquitin thioesters, this process comprising preparing a polypeptide or a fragment thereof, being attached to a latent thioester functionality, which can then be ligated with a second polypeptide fragment, followed by selective activation of the latent thioester functionality group, to provide the requested polypeptide thioester. There are also provided the polypeptides obtained by this method, specific unnatural amino acids useful to be incorporated within the polypeptide thioesters, and kits for preparing them.

公开(公告)号：EP2427175A2

公开(公告)日：2012-03-14

申请号：EP10725503.6

申请日：2010-05-04

申请人： Ben-gurion University Of The Negev Research And Development Authority

发明人： LINDER, Charles ,  GRINBERG, Sarina ,  HELDMAN, Eliahu

IPC分类号： A61K9/127 ,  A61K9/51

CPC分类号： A61K9/1272 ,  A61K9/0019 ,  A61K9/127 ,  A61K9/51 ,  C07C229/22

摘要： Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.

摘要翻译： 提供包含至少一种多头两亲化合物的纳米尺寸颗粒，其中所述多头两亲化合物的至少一个头基可选择性切割或含有选择性可切割基团，以及至少一种生物活性剂，其均为 封装在纳米颗粒内并与其非共价缔合。

公开(公告)号：EP2346431A1

公开(公告)日：2011-07-27

申请号：EP09828725.3

申请日：2009-11-03

申请人： Ben-Gurion University of The Negev Research and Development Authority

发明人： ORION, Itzhak

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B90/39 ,  A61B2018/00166 ,  A61B2018/00404 ,  A61B2018/0041 ,  A61B2018/00416 ,  A61B2018/00422 ,  A61B2018/00428 ,  A61B2018/0212 ,  A61B2018/1266 ,  A61B2018/1435

摘要： The present invention generally relates to a flexible catheter device capable of being introduced into body passages, withdraw fluids therefrom or introduce fluids thereinto, and which includes electrodes configured to apply electrical signals in the body passage for carrying out thrombus dissolution and/or thrombectomy, wherein one of said electrodes is designed to contact the thrombus material and remove it or dissolve it, and wherein the electrical voltage signals are a unipolar pulsatile voltage signal.

公开(公告)号：EP2328611A2

公开(公告)日：2011-06-08

申请号：EP09812778.0

申请日：2009-09-10

申请人： Ben Gurion University Of The Negev Research And Development Authority

发明人： MIZRACHI-NEBENZAHL, Yaffa ,  DAGAN, Ron

IPC分类号： A61K39/09 ,  A61K38/00

CPC分类号： C07K7/08 ,  C07K7/06

摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of pathogen cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of pathogen cell adhesion and cell adhesion- mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of infectious diseases.

公开(公告)号：EP2326340A2

公开(公告)日：2011-06-01

申请号：EP09812777.2

申请日：2009-09-10

申请人： Ben Gurion University Of The Negev Research And Development Authority

发明人： MIZRACHI-NEBENZAHL, Yaffa ,  DAGAN, Ron

IPC分类号： A61K38/00 ,  A61K38/04

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/3156

摘要： The present invention relates to novel compounds that are useful for inhibition and prevention of pathogen cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of pathogen cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of infectious diseases.

公开(公告)号：EP2275126A2

公开(公告)日：2011-01-19

申请号：EP10011326.5

申请日：2003-04-01

申请人： Ben Gurion University Of The Negev Research And Development Authority

发明人： The designation of the inventor has not yet been filed

IPC分类号： A61K39/09 ,  A61K39/00 ,  A61K39/385 ,  A61K39/02 ,  C07K1/00

CPC分类号： A61K39/092 ,  Y10S530/825

摘要： The invention relates to a vaccine composition comprising as an active ingredient an effective amount of an isolated S. pneumoniae PTS system, mannose-specific IIAB components (PTS, Accession No. NP_344822), optionally together with one or more pharmaceutically acceptable adjuvant(s).

摘要翻译： 本发明涉及疫苗组合物，其包含有效量的分离的肺炎链球菌PTS系统，甘露糖特异性IIAB组分（PTS，登录号NP_344822），任选与一种或多种药学上可接受的佐剂一起， 。

公开(公告)号：EP2238254A1

公开(公告)日：2010-10-13

申请号：EP09705862.2

申请日：2009-02-01

申请人： Yeda Research and Development Co. Ltd. ,  Ben-gurion University Of The Negev Research And Development Authority

发明人： FLUHR, Robert ,  SAGI, Moshe

IPC分类号： C12N15/82 ,  A01H5/00

CPC分类号： A01N47/28 ,  A01N3/00 ,  A01N43/50 ,  A01N43/90 ,  C12N15/8243 ,  C12N15/8269 ,  C12N15/8271

摘要： The present invention relates to regulation of ureide levels for optimal plant survival during nutrient remobilization such as occurs during normal growth, dark stress and senescence. Plants can be genetically engineered or selected using a suitable gene marker to have enhanced ureide accumulation. The present invention further provides methods of protecting plants, or extending the shelf life of fresh plant produce by application of exogenous ureides.