公开(公告)号：EP1635904A4

公开(公告)日：2008-10-01

申请号：EP04776919

申请日：2004-06-18

申请人： NEUROSIGNAL TECHNOLOGIES INC

发明人： SCHULER ELEANOR ,  LEE CLAUDE K

IPC分类号： A61N1/36 ,  A61B5/04 ,  A61F4/00 ,  A61N1/08 ,  A61N1/32 ,  G06F3/00 ,  G06F19/00

CPC分类号： A61N1/36003 ,  A61B5/04001 ,  A61N1/08 ,  A61N1/32 ,  A61N1/36014 ,  A61N1/36017 ,  A61N1/36042 ,  G06F3/015 ,  G06F19/3481

摘要： A method and device for skeletal muscle control. The method comprises selecting neuro-electrical coded signals from a storage area that are representative of body organ function. The selected neuro-electrical coded signals are then transmitted to a treatment member, which is in direct contact with the body, and which then broadcasts the neuro-electrical coded signals to a specific body skeletal muscle nerve or organ to modulate the body organ functioning. A control module is provided for transmission to the treatment member. The control module contains the neuro-electrical coded signals which are selected and transmitted to the treatment member, and computer storage can be provided for greater storage capacity and manipulation of the neuro-electrical coded signals.

公开(公告)号：EP1728532A1

公开(公告)日：2006-12-06

申请号：EP06017378.8

申请日：2000-11-03

申请人： MEDTRONIC, INC.

发明人： Donovan, Maura, G. ,  Soykan, Orhan

IPC分类号： A61N1/36

CPC分类号： A61N1/36042

摘要： An implantable system is provided that includes: a cell repopulation source comprising genetic material, undifferentiated and/or differentiated contractile cells, or a combination thereof capable of forming new contractile tissue in and/or near and infarct zone of a patient's myocardium; and an electrical stimulation device for electrically stimulating the new contractile tissue in and/or near the infarct zone of the patient's myocardium or otherwise damaged or diseased myocardial tissue.

摘要翻译： 提供了一种可植入系统，其包括：包含遗传材料，未分化和/或分化的收缩细胞或能够在患者心肌的和/或邻近和梗塞区域内形成新的收缩组织的组合的细胞增殖源; 以及电刺激装置，用于电刺激患者心肌梗死区或其他受损或患病心肌组织中和/或附近的新收缩组织。

公开(公告)号：EP0657185B1

公开(公告)日：2000-08-16

申请号：EP94309221.3

申请日：1994-12-09

申请人： MEDTRONIC, INC.

发明人： Camps, Antoine ,  Dreessen, Chrit W. ,  Polz, Michel W.J. ,  Grandjean, Pierre A.

IPC分类号： A61N1/36 ,  A61N1/05

CPC分类号： A61N1/36042 ,  A61N1/05

公开(公告)号：EP0722348B1

公开(公告)日：1998-10-28

申请号：EP94926622.5

申请日：1994-08-26

申请人： MEDTRONIC, INC.

发明人： GRANDJEAN, Pierre A. ,  LEINDERS, Robert ,  BOURGEOIS, Ivan

IPC分类号： A61N1/37

CPC分类号： A61N1/3708 ,  A61N1/36042

摘要： An end-of-life (EOL) indicator for an implantable pulse generator (IPG) - especially of the neuromuscular stimulation variety - indicates an approaching battery EOL condition via an electrocardiogram (ECG) by changing the nature of the muscle stimulation burst signals. IPG internal circuitry detects an approaching EOL condition and modifies the burst signals by, for example, decreasing the number of pulses in a burst, increasing the heart contraction-to-powering-muscle contraction ratio, or alternating between two numbers of pulses in successive burst cycles. The approaching battery EOL condition can be easily ascertained via trans-telephonic monitoring by analyzing a transmitted ECG alone, for the above-mentioned burst signal changes. By observing the patterns in the ECG caused by the burst signal changes, a clinician could be aware of an approaching EOL without having known the original muscle stimulation burst signal parameters.

公开(公告)号：EP0759309A3

公开(公告)日：1998-05-27

申请号：EP96305588

申请日：1996-07-30

申请人： MEDTRONIC INC

发明人： FRANCISCHELLI DAVID ,  GEALOW KENDRA K ,  GRANDJEAN PIERRE A ,  HAMMARGREN JOHN ,  NEISZ JOHANN J ,  PETERSON DAVID K

IPC分类号： A61N1/365 ,  A61N1/36 ,  A61N1/362 ,  A61N1/39

CPC分类号： A61N1/3621 ,  A61N1/36042 ,  A61N1/3962

摘要： A device and algorithm for a combined cardiomyostimulator and a cardiac pacer-cardioverter-defibrillator. In particular the present invention operates, in a first embodiment, to deliver stimulation to a skeletal muscle 3 grafted about a heart 2; sense depolarizations of a patient's heart; measure the intervals separating successive depolarizations of the patient's heart; define first and second interval ranges; determine the number of the measured intervals falling within the first and second interval ranges; inhibit the delivery of stimulation to a skeletal muscle grafted about a heart upon the sensing of a depolarization within the first or second interval range; detect the occurrence of a first type of arrhythmia when the number of the measured intervals falling within the first interval range equals a first predetermined value; detect the occurrence of a second type of an arrhythmia when the number of the intervals falling within the second interval range equals a second predetermined value; deliver a first type of arrhythmia therapy in response to the detection of the first arrhythmia; and deliver a second type of arrhythmia therapy in response to the detection of the second arrhythmia, the second type of arrhythmia therapy having a cardiac stimulation component and a skeletal muscle component.

公开(公告)号：EP0744980A4

公开(公告)日：1998-02-25

申请号：EP95905858

申请日：1994-12-06

申请人： UNIV JEFFERSON

发明人： CHANCELLOR MICHAEL B

IPC分类号： A61N1/36

CPC分类号： A61N1/36007 ,  A61N1/36042

摘要： An implantable micturition inducer is disclosed. The device comprises an implantable actuatable signal generator (15) that comprises one or more switches (17) and a power source, and at least one electrical lead (16) having one end connected to the signal generator and the other end adapted to be connected to muscle (14) transected to form a muscle bag around an individual's bladder. Actuation of the switch or switches results in the delivery of a series of stimulus pulses from the signal generator to the muscle bag which are sufficient to cause the muscle bag to contract and thereby induce micturition on demand. Methods for inducing micturition in patients with areflexic bladders of an otherwise diminished capacity to intentionally micturate are disclosed.

公开(公告)号：EP0759312A2

公开(公告)日：1997-02-26

申请号：EP96305736.9

申请日：1996-08-02

申请人： MEDTRONIC, INC.

发明人： Francischelli, David ,  Hammargren, John ,  Neisz, Johann J. ,  Peterson, David K. ,  Weijand, Koen J.

IPC分类号： A61N1/36 ,  A61N1/39

CPC分类号： A61N1/3621 ,  A61N1/36042 ,  A61N1/3962

摘要： A cardiac assist device having muscle augmentation after a confirmed arrhythmia. In particular the present invention operates, in a first embodiment, to sense a cardiac event, next it determines whether the cardiac event is a cardiac arrhythmia, if the event is not a cardiac arrhythmia the devices delivers stimulation to a skeletal muscle grafted about a heart, but if the event is a cardiac arrhythmia the device inhibits delivery of skeletal muscle stimulation and once the arrhythmia is confirmed, then delivers therapeutic stimulation to the heart. In a second embodiment the present invention operates to re-initiate skeletal muscle stimulation once the arrhythmia is confirmed but prior to the delivery of the therapeutic stimulation to the heart.

摘要翻译： 一种心脏辅助装置，在证实心律失常后具有肌肉增强功能。 具体地，本发明在第一实施例中用于感测心脏事件，接下来确定心脏事件是否为心律失常，如果事件不是心律失常，那么设备将刺激递送到围绕心脏移植的骨骼肌 ，但如果该事件是心律失常，则该装置抑制骨骼肌刺激的传递，并且一旦证实了心律失常，则将治疗刺激传递给心脏。 在第二实施例中，一旦证实心律失常，但在将治疗刺激递送至心脏之前，本发明用于重新启动骨骼肌肉刺激。

公开(公告)号：EP0759309A2

公开(公告)日：1997-02-26

申请号：EP96305588.4

申请日：1996-07-30

申请人： MEDTRONIC, INC.

发明人： Francischelli, David ,  Gealow, Kendra K. ,  Grandjean, Pierre A. ,  Hammargren, John ,  Neisz, Johann J. ,  Peterson, David K.

IPC分类号： A61N1/36 ,  A61N1/39

CPC分类号： A61N1/3621 ,  A61N1/36042 ,  A61N1/3962

摘要： A device and algorithm for a combined cardiomyostimulator and a cardiac pacer-cardioverter-defibrillator. In particular the present invention operates, in a first embodiment, to deliver stimulation to a skeletal muscle 3 grafted about a heart 2; sense depolarizations of a patient's heart; measure the intervals separating successive depolarizations of the patient's heart; define first and second interval ranges; determine the number of the measured intervals falling within the first and second interval ranges; inhibit the delivery of stimulation to a skeletal muscle grafted about a heart upon the sensing of a depolarization within the first or second interval range; detect the occurrence of a first type of arrhythmia when the number of the measured intervals falling within the first interval range equals a first predetermined value; detect the occurrence of a second type of an arrhythmia when the number of the intervals falling within the second interval range equals a second predetermined value; deliver a first type of arrhythmia therapy in response to the detection of the first arrhythmia; and deliver a second type of arrhythmia therapy in response to the detection of the second arrhythmia, the second type of arrhythmia therapy having a cardiac stimulation component and a skeletal muscle component.

摘要翻译： 的装置和算法用于组合cardiomyostimulator和心脏起搏器-心律转复除颤器。 特别是在本发明工作在第一实施方式中，递送刺激到接枝约一个心脏3 2骨骼肌; 患者的心脏感去极化; 测量间隔分离患者心脏的去极化连续; 限定第一和第二间隔的范围; 确定性矿井间隔测量落在第一和第二间隔的范围内的数目; 抑制到接枝大约在所述第一或第二时间间隔范围内的去极化的感测心脏的骨骼肌递送刺激; 检测第一类型的心律失常当测得的时间间隔落在第一间隔范围内的数目等于第一预定值的的发生; 检测的第二类型的心律不齐。当间隔落在第二间隔范围内的数目等于第二预定值的发生; 响应于检测到第一心律失常的输送第一类型的心律失常治疗; 以及响应提供一个第二类型的心律不齐的治疗，以检测所述第二心律失常，具有心脏刺激组分和骨骼肌组分的第二类型的心律失常治疗。

公开(公告)号：EP0536858B1

公开(公告)日：1996-07-24

申请号：EP92250257.0

申请日：1992-09-14

申请人： BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin

发明人： Schaldach, Max, Prof. Dr.

IPC分类号： A61N1/365 ,  A61M1/12

CPC分类号： A61M1/10 ,  A61M1/1003 ,  A61N1/36042

公开(公告)号：EP0547733A3

公开(公告)日：1995-01-11

申请号：EP92306759.9

申请日：1992-07-23

申请人： TELECTRONICS N.V.

发明人： Collins, Kenneth Andrew

IPC分类号： A61N1/36 ,  A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36042 ,  A61M1/1003 ,  A61M1/1068 ,  A61M1/1086 ,  A61M1/12 ,  A61M1/127 ,  A61M2205/33 ,  A61M2205/3303 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/3962

摘要： An antiarrhythmia pacemaker (17) and method detect and confirm the occurrence of an abnormal condition of a patient's heart selected from the group comprising tachycardia, fibrillation and precursors thereof, and, in response thereto, deliver an antiarrhythmia therapy to the patient which includes two components, electrical stimulation of the heart and electrical stimulation of a skeletal muscle graft (9) which has been surgically grafted to the heart to augment performance of the heart. The antiarrhythmia pacemaker (17) and method control electrical stimulation of the heart in terms of timing, frequency, amplitude, duration and other operational parameters, to provide such pacing therapies as antitachycardia pacing, cardioversion and defibrillation. A skeletal muscle graft stimulation electrode, which is driven by a skeletal muscle pulse stimulator (20) stimulates preselected nerve fibers within the skeletal muscle graft (9). An arrhythmia therapy control responds to the detection and confirmation of an abnormal heart condition by controlling and coordinating the operation of the heart stimulator and the skeletal muscle graft stimulator (20) to direct performance of a combined heart stimulation and skeletal muscle graft stimulation therapy.

摘要翻译： 抗心律失常起搏器（17）和方法检测并确认选自包括心动过速，心脏颤动及其前驱在内的患者心脏异常情况的发生，并且响应于此，向患者提供抗心律失常疗法，其包括两种成分 ，心脏的电刺激和骨骼肌肉移植物（9）的电刺激，所述骨骼肌肉移植物已经手术移植到心脏以增强心脏的表现。 抗心律失常起搏器（17）和方法在时间，频率，振幅，持续时间和其他操作参数方面控制心脏的电刺激，以提供诸如抗心动过速起搏，心脏复律和除颤的起搏治疗。 由骨骼肌脉冲刺激器（20）驱动的骨骼肌肉移植物刺激电极刺激骨骼肌肉移植物（9）内的预选神经纤维。 心律失常治疗控制通过控制和协调心脏刺激器和骨骼肌移植刺激器（20）的操作来指导组合心脏刺激和骨骼肌移植刺激治疗的执行，从而对异常心脏状况的检测和确认做出响应。