公开(公告)号：EP3303285A1

公开(公告)日：2018-04-11

申请号：EP16726113.0

申请日：2016-06-01

Applicant: Syngenta Participations AG

Inventor： BENFATTI, Fides ,  JEANGUENAT, André

IPC: C07C279/00 ,  C07C335/00

CPC classification number: C07C281/14 ,  A01N47/24 ,  A01N47/34 ,  C07C271/60 ,  C07C337/08 ,  C07C2602/08

Abstract: The present invention relates to compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.

公开(公告)号：EP3294690A1

公开(公告)日：2018-03-21

申请号：EP16723995

申请日：2016-05-11

Applicant: BASF SE

Inventor： NAVE BARBARA ,  DICKHAUT JOACHIM ,  NESVADBA PETER ,  SISAY MIHIRET TEKESTE ,  WISSEMEIER ALEXANDER ,  ZERULLA WOLFRAM ,  PASDA GREGOR ,  WALLQUIST OLOF ,  CUNNINGHAM ALAN FRANCIS

IPC: C05G3/08 ,  C07C321/08 ,  C07C321/18 ,  C07C323/45

CPC classification number: C05G3/08 ,  C07C337/08 ,  Y02P60/218

Abstract: The invention concerns the use of thioether compounds of formula Ias nitrification inhibitors, and agricultural mixtures and compositions comprising said thioether compounds.

公开(公告)号：EP3138838A1

公开(公告)日：2017-03-08

申请号：EP16192483.2

申请日：2011-01-31

Applicant: Dana-Farber Cancer Institute, Inc.

Inventor： WALENSKY, Loren, D. ,  STEWART, Michelle, L. ,  COHEN, Nicole

IPC: C07D277/40 ,  C07D417/04 ,  C07D405/14 ,  C07D413/14 ,  C07D327/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/08 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D239/60 ,  C07D413/06 ,  C07D417/14 ,  C07D249/12 ,  C07D277/34 ,  C07D513/04 ,  C07D307/54 ,  C07D279/06

CPC classification number: C07D513/04 ,  C07C251/20 ,  C07C251/84 ,  C07C311/20 ,  C07C335/16 ,  C07C337/08 ,  C07C2602/10 ,  C07D239/60 ,  C07D249/12 ,  C07D277/34 ,  C07D279/06 ,  C07D307/54 ,  C07D327/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/08 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.

Abstract translation: 本发明涉及能选择性结合的存活蛋白MCL-1具有高亲和性和选择性，药物组合物含有测试化合物和使用这些化合物或组合物用于调制MCL-1活性的化合物和用于治疗过度增生性疾病，血管生成障碍，细胞 周期调节性疾病，自体吞噬调节紊乱，炎性病症，和/或感染性疾病和/或用于增强细胞植入和/或伤口修复，作为唯一的药物或与其它活性成分组合。

公开(公告)号：EP2991968A4

公开(公告)日：2017-01-11

申请号：EP14791590

申请日：2014-05-01

Applicant: NEOCULI PTY LTD

Inventor： PAGE STEPHEN ,  GARG SANJAY ,  KEENAN MARTINE ,  MCCLUSKEY ADAM ,  STEVENS ANDREW

IPC: C07C279/02 ,  A61K31/12 ,  A61K31/155 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/4192 ,  A61K31/44 ,  A61K31/498 ,  A61P31/04 ,  C07C241/04 ,  C07C249/14 ,  C07C275/68 ,  C07C281/08 ,  C07C281/18 ,  C07C337/08 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12

CPC classification number: C07D239/50 ,  A01N43/54 ,  A01N47/44 ,  A61K31/14 ,  A61K31/155 ,  A61K31/17 ,  A61K31/175 ,  A61K31/381 ,  A61K31/404 ,  A61K31/505 ,  A61K45/06 ,  C07C281/08 ,  C07C281/18 ,  C07C323/45 ,  C07C337/08 ,  C07D209/14 ,  C07D209/40 ,  C07D213/53 ,  C07D215/12 ,  C07D251/66 ,  C07D295/125 ,  C07D307/56 ,  C07D333/58 ,  C07F9/65122 ,  A61K2300/00

公开(公告)号：EP2847163A4

公开(公告)日：2016-01-20

申请号：EP13787229

申请日：2013-03-14

Applicant: UNIV HOWARD

Inventor： NEKHAI SERGEI ,  KOVALSKYY DMYTRO BORISOVYCH

IPC: C07C337/00 ,  A61P35/00 ,  C07C337/08 ,  C07D213/53

CPC classification number: C07D213/59 ,  C07C337/08 ,  C07D213/53

Abstract: The present invention relates to chelator compounds for chelating metal ions. In particular, the present invention relates to (thio)semicarbazone compounds and (thio)hydrazone compounds, such as PpYeT and PpYaT, which are chelators for metal ions, including iron ions. Therapeutic use of such compounds and/or their metal ion complexes, includes methods for treating and inhibiting HIV-1 replication, particularly in HIV-1 infected cells.

公开(公告)号：EP2838880A4

公开(公告)日：2015-12-09

申请号：EP13778788

申请日：2013-04-17

Applicant: MERRIMACK PHARMACEUTICALS INC

Inventor： DRUMMOND DARYL C ,  KIRPOTIN DMITIRI B ,  WICKHAM THOMAS ,  HENDRIKS BART S ,  AGRESTA SAMUEL ,  LEE HELEN

IPC: C07C337/08 ,  A61K51/04 ,  A61K51/12

CPC classification number: A61K51/0478 ,  A61K9/1271 ,  A61K31/4745 ,  A61K31/704 ,  A61K51/1234 ,  C07C337/08

Abstract: The present invention relates to a novel composition useful in targeted diagnostic and/or therapy of a target site, such as cancerous tissue. The composition and methods disclosed herein find particular use in diagnosing and imaging cancerous tissue. The present invention provides a new diagnostic tool for the utilization of positron emission tomography (PET) imaging technique.

Abstract translation: 本发明涉及可用于目标部位如癌组织的靶向诊断和/或治疗的新型组合物。 本文公开的组合物和方法在诊断和成像癌组织中特别有用。 本发明提供了一种用于正电子发射断层摄影（PET）成像技术的新诊断工具。

公开(公告)号：EP2847163A1

公开(公告)日：2015-03-18

申请号：EP13787229.7

申请日：2013-03-14

Applicant: Howard University

Inventor： NEKHAI, Sergei ,  KOVALSKYY, Dmytro Borisovych

IPC: C07C337/00 ,  C07C337/08 ,  A61P35/00

CPC classification number: C07D213/59 ,  C07C337/08 ,  C07D213/53

Abstract: The present invention relates to chelator compounds for chelating metal ions. In particular, the present invention relates to (thio)semicarbazone compounds and (thio)hydrazone compounds, such as PpYeT and PpYaT, which are chelators for metal ions, including iron ions. Therapeutic use of such compounds and/ or their metal ion complexes, includes methods for treating and inhibiting HIV-1 replication, particularly in HIV-1 infected cells.

公开(公告)号：EP2057118B1

公开(公告)日：2015-03-04

申请号：EP07837060.8

申请日：2007-08-20

Applicant: Synta Pharmaceuticals Corp.

Inventor： KOYA, Keizo ,  SUN, Lijun ,  CHEN, Shoujun ,  JIANG, Jun

IPC: C07C337/08 ,  C07D213/53 ,  C07D307/52 ,  C07D333/22 ,  A61K31/166 ,  A61P35/00

CPC classification number: C07C327/56 ,  C07C337/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D211/84 ,  C07D213/53 ,  C07D239/04 ,  C07D263/10 ,  C07D271/10 ,  C07D307/52 ,  C07D317/28 ,  C07D333/22 ,  C07D339/08 ,  C07D413/14

公开(公告)号：EP2828241A2

公开(公告)日：2015-01-28

申请号：EP13765045.3

申请日：2013-03-05

Applicant: Oxigene, Inc. ,  Baylor University

Inventor： CHAPLIN, David, J. ,  GADDALE DEVANNA, Kumar, Kishore ,  PARKER, Erica ,  PINNEY, Kevin, G. ,  SONG, Jiangli ,  TRAWICK, Mary, L.

IPC: C07C337/08

CPC classification number: C07C337/08 ,  C07C49/786

Abstract: This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.

公开(公告)号：EP2528893A4

公开(公告)日：2013-07-24

申请号：EP11737834

申请日：2011-01-31

Applicant: DANA FARBER CANCER INST INC

Inventor： WALENSKY LOREN D ,  STEWART MICHELLE L ,  COHEN NICOLE

IPC: C07C251/20 ,  A61K31/41 ,  A61P35/00 ,  C07C251/84 ,  C07C335/16 ,  C07D215/16 ,  C07D249/08 ,  C07D403/04 ,  C07D403/08

CPC classification number: C07D513/04 ,  C07C251/20 ,  C07C251/84 ,  C07C311/20 ,  C07C335/16 ,  C07C337/08 ,  C07C2602/10 ,  C07D239/60 ,  C07D249/12 ,  C07D277/34 ,  C07D279/06 ,  C07D307/54 ,  C07D327/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/08 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

Abstract: This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for modulating MCL-1 activity and for treating hyperproliferative disorders, angiogenesis disorders, cell cycle regulation disorders, autophagy regulation disorders, inflammatory disorders, and/or infectious disorders and/or for enhancing cellular engraftment and/or wound repair, as a sole agent or in combination with other active ingredients.