公开(公告)号：EP3145489A1

公开(公告)日：2017-03-29

申请号：EP15727528.0

申请日：2015-05-22

申请人： TherapeuticsMD, Inc.

发明人： BERNICK, Brian A. ,  PERSICANER, Peter H.R. ,  AMADIO, Julia M.

IPC分类号： A61K9/00 ,  A61K31/565 ,  A61K31/57 ,  A61P5/30 ,  A61P5/34

CPC分类号： A61K31/565 ,  A61K9/10 ,  A61K9/4858 ,  A61K31/57 ,  A61K2300/00

摘要： Pharmaceutical compositions for co-administering estradiol and progesterone to a human subject in need thereof are provided. In some embodiments, the pharmaceutical composition comprises solubilized estradiol, suspended progesterone, and a solubilizing agent comprising a medium chain (C6-C12) oil.

摘要翻译： 提供了将雌二醇和孕酮共同施用于有需要的人类受试者的药物组合物。 在一些实施方案中，药物组合物包含溶解的雌二醇，悬浮的孕酮和包含中链（C6-C12）油的增溶剂。

公开(公告)号：EP2534166B1

公开(公告)日：2015-04-08

申请号：EP11702458.8

申请日：2011-02-08

申请人： Bayer Intellectual Property GmbH

发明人： SCHWEDE, Wolfgang ,  KLAR, Ulrich ,  MÖLLER, Carsten ,  ROTGERI, Andrea ,  BONE, Wilhelm ,  HUWE, Christoph

IPC分类号： C07J41/00 ,  C07J43/00 ,  A61K31/567 ,  A61P5/34

CPC分类号： C07J43/003 ,  A61K31/573 ,  A61K31/58 ,  C07J41/0083

公开(公告)号：EP1660009B1

公开(公告)日：2015-01-28

申请号：EP04769463.3

申请日：2004-08-27

申请人： Miscon Trading S.A.

发明人： BOVINDARAJAN, Mirudhubashini

IPC分类号： A61K9/16 ,  A61K31/57 ,  A61P5/34 ,  A61P15/02

CPC分类号： A61K31/57 ,  A61K9/0019 ,  A61K9/0034 ,  A61K9/10

公开(公告)号：EP2440567B1

公开(公告)日：2013-04-03

申请号：EP10724830.4

申请日：2010-06-09

申请人： MSD Oss B.V.

发明人： DIJCKS, Fredericus, Antonius ,  LOOZEN, Hubert, Jan, Jozef ,  ADDO, Samira ,  EDERVEEN, Antonius, Gerardus, Hendrikus

IPC分类号： C07J53/00 ,  A61K31/57 ,  A61P5/30 ,  A61P5/32 ,  A61P5/34 ,  A61P5/36

CPC分类号： C07J53/002

摘要： The present invention relates to substituted steroid compounds having the formula (I) Wherein R1 is H or halogen; R2 is H, (1C-4C)alkyl, (1C-4C)acyl, glucuronyl or sulfamoyl; R3 is H or halogen; R4 is H, (1C-4C)alkyl, (2C-4C)alkenyl or (2C-4C)alkynyl; R5 is methyl or ethyl; R6 is H or methyl; R7 is H or methyl; R8 is H or acyl for use in the treatment and prevention of endometriosis, for contraception, for hormonal therapy in perimenopausal and post-menopausal women, for the treatment of osteoporosis and for the treatment uterine fibroids and other menstrual-related disorders, such as dysfunctional uterine bleeding.

公开(公告)号：EP2520301A2

公开(公告)日：2012-11-07

申请号：EP10837927.2

申请日：2010-12-14

申请人： Techsphere, S.A. De Cv.

发明人： ÁNGELES URIBE, Juan ,  SAVOIR VILBOEUF, John Claude

IPC分类号： A61K31/565 ,  A61K31/57 ,  A61K9/16 ,  A61P5/30 ,  A61P5/34

CPC分类号： A61K45/06 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/14 ,  A61K9/145 ,  A61K31/565 ,  A61K31/57 ,  A61K2300/00

摘要： Parenteral pharmaceutical formulation or composition, in suspension, having sustained release, containing suspended particles of estradiol and progesterone for hormonal replacement in female mammals in low and ultralow dosage; the formulation consists of an injectable suspension comprising particles of estradiol, particles of progesterone, a surfactant agent, an isosmotic agent, a thickening agent, and one or more preservation agents, wherein the estradiol is in particles having a size between 1 and 100 microns and the progesterone is in particles having a size between 1 and 100 microns, for application thereof in parenteral, intramuscular, subcutaneous or intradermal pharmaceutical form.

摘要翻译： 胃肠道药物制剂或悬浮液中的组合物，具有持续释放，含有雌二醇和孕酮用于在低和超低剂量的雌性哺乳动物的激素替代的悬浮颗粒; 可注射的悬浮液，其包括雌二醇的颗粒，孕酮，表面活性剂的颗粒，至等渗剂，增稠剂，和一种或多种保存剂的制剂besteht，worin所述雌二醇是具有1至100微米之间的尺寸的颗粒 黄体酮是在具有1至100微米之间的尺寸的颗粒，用于肠胃外，肌内，皮下或皮内的药物形式及其应用。

公开(公告)号：EP2238147B1

公开(公告)日：2012-10-24

申请号：EP08867342.1

申请日：2008-12-23

申请人： Bayer Intellectual Property GmbH

发明人： KLAR, Ulrich ,  KUHNKE, Joachim ,  BOHLMANN, Rolf ,  HÜBNER, Jan ,  RING, Sven ,  FRENZEL, Thomas ,  MENGES, Frederik ,  BORDEN, Steffen ,  MUHN, Hans, Peter ,  PRELLE, Katja

IPC分类号： C07J21/00 ,  C07J41/00 ,  C07J53/00 ,  A61K31/58 ,  A61P5/34 ,  A61P5/42 ,  A61P5/26

CPC分类号： C07J21/00 ,  C07J41/0016 ,  C07J53/001 ,  C07J53/007

公开(公告)号：EP2297177B1

公开(公告)日：2012-06-20

申请号：EP09757194.7

申请日：2009-05-26

申请人： Bayer Pharma Aktiengesellschaft

发明人： RING, Sven ,  BOHLMANN, Rolf ,  KUHNKE, Joachim ,  ZORN, Ludwig ,  BORDEN, Steffen ,  PRELLE, Katja

IPC分类号： C07J53/00 ,  A61K31/58 ,  A61P5/34 ,  A61P5/42 ,  A61P5/28

CPC分类号： C07J53/008

摘要： The present invention relates to C-ring-substituted pregn-4-ene-21,17-carbolactones of the general formula I in which R
6,7 is an α- or β-methylene and R
9 is a hydrogen atom and R
11 is a bromine, chlorine or fluorine atom or R
9 and R
11 together are a bond. The novel compounds are gestagenic antimineralocorticoids.

公开(公告)号：EP1751189B1

公开(公告)日：2011-06-15

申请号：EP05734038.2

申请日：2005-04-15

申请人： Banerjee, Subhasis

发明人： Banerjee, Subhasis

IPC分类号： C07K14/72 ,  C12N15/12 ,  A61K38/17 ,  A61P5/34 ,  C07K16/28

CPC分类号： C07K14/72

摘要： The invention relates to a solute e luteinising hormone/chorionic gonadotropin receptor (LHCGR) protein and its use in diagnosing, treating and preventing conditions associated with over- and under-production of the said receptor, with over- and under-production of luteinising hormone, with over- and under-production of chorionic gonadotropin, with reproductive failure, with gonadal cancer and metastases, and Alzheimer's disease.

公开(公告)号：EP2265629A2

公开(公告)日：2010-12-29

申请号：EP09718334.7

申请日：2009-03-04

申请人： Evestra, Inc.

发明人： NICKISCH, Klaus ,  RAO, Pemmaranu N. ,  CESSAC, James W. ,  SIMMONS, Anne Marie

IPC分类号： C07J53/00 ,  A61K31/58 ,  A61P5/34 ,  A61P5/42

CPC分类号： C07J53/007 ,  C07J53/008

摘要： Described herein are bismethylene-17α carbolactone derivatives having progestational and/or antimineralocorticoid and/or aldosterone antagonistic activity. Also described herein are methods of preparing and using these novel compounds.

公开(公告)号：EP2238151A1

公开(公告)日：2010-10-13

申请号：EP08868806.4

申请日：2008-12-23

申请人： Bayer Schering Pharma Aktiengesellschaft

发明人： KLAR, Ulrich ,  KUHNKE, Joachim ,  BOHLMANN, Rolf ,  HÜBNER, Jan ,  RING, Sven ,  FRENZEL, Thomas ,  MENGES, Frederik ,  BORDEN, Steffen ,  MUHN, Hans, Peter ,  PRELLE, Katja

IPC分类号： C07J53/00 ,  A61P5/34 ,  A61K31/585

CPC分类号： C07J53/00 ,  C07J19/00

摘要： The invention relates to 17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivatives with the chemical formula (I) wherein R4, R6a, R6b, R7, R15, R16a, R16b, R18 and Z have the designations given in claim 1, and to the solvates, hydrates, stereoisomers and salts thereof. The invention also relates to the use of said derivatives for producing a medicament for oral contraception and for the treatment of premenopausal, perimenopausal and postmenopausal troubles, and medicaments containing said derivatives. The derivatives according to the invention have a gestagen effect, and in preferred cases, also an anti-mineral corticoid and neutral to lightly androgenous effect.