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767 条记录 (耗时 0.03 秒)

    PYRIMIDINE DERIVATIVES AND PROCESS FOR PREPARING THE SAME
    63.
    发明公开
    PYRIMIDINE DERIVATIVES AND PROCESS FOR PREPARING THE SAME 审中-公开
    嘧啶衍生物及其制备方法

    公开(公告)号：EP1346985A1

    公开(公告)日：2003-09-24

    申请号：EP01995000.5

    申请日：2001-12-25

    申请人： ONO PHARMACEUTICAL CO., LTD.

    发明人： SUGIURA, Tsuneyuki ,  HORIUCHI, Toshihide ,  MIYAZAKI, Toru ,  KOJIMA, Tsutomu ,  HASHIMOTO, Shinsuke

    IPC分类号： C07D239/47 ,  C07D413/12 ,  C07D239/54 ,  C07D405/04

    CPC分类号： C07D239/47 ,  C07D239/545 ,  C07D405/04 ,  C07D413/12

    摘要： A pyrimidine derivative compound of formula (I) or a salt thereof and a method for the preparation thereof.
    The pyrimidine derivative of formula (I) or a salt thereof is useful as important synthetic intermediate for a pharmaceutical a drug. The method for the preparation of the present invention can provide the compound of formula (E), which is useful as a pharmaceutical drug, more efficiently than conventional method does.
    (All symbols in the formulae have the same meaning as depicted in the specification)

    摘要翻译： 式（I）的嘧啶衍生化合物或其盐及其制备方法。 式（I）的嘧啶衍生物或其盐可用作药物药物的重要合成中间体。 用于制备本发明的方法可以比常规方法更有效地提供可用作药物的式（E）化合物。 （公式中的所有符号具有与说明书中描述的相同的含义）

    URACIL DERIVATIVES, AND ANTITUMOR EFFECT POTENTIATOR AND ANTITUMOR AGENT CONTAINING THE SAME
    66.
    发明授权
    URACIL DERIVATIVES, AND ANTITUMOR EFFECT POTENTIATOR AND ANTITUMOR AGENT CONTAINING THE SAME 失效
    尿嘧啶和含有抗肿瘤作用放大器及抗肿瘤药

    公开(公告)号：EP0763529B1

    公开(公告)日：2003-07-23

    申请号：EP96907693.4

    申请日：1996-03-28

    申请人： TAIHO PHARMACEUTICAL COMPANY LIMITED

    发明人： YANO, Shingo ,  TADA, Yukio ,  KAZUNO Hideki ,  SATO, Tsutomu ,  YAMASHITA, Junichi ,  SUZUKI, Norihiko ,  EMURA, Tomohiro ,  FUKUSHIMA, Masakazu ,  ASAO, Tetsuji

    IPC分类号： C07D239/54 ,  C07D401/06 ,  A61K31/505

    CPC分类号： C07D239/54 ,  C07D231/12 ,  C07D233/56 ,  C07D239/553 ,  C07D249/08 ,  C07D403/06 ,  C07D403/12

    摘要： Uracil derivatives represented by general formula (1) or salts thereof, wherein R1 represents chloro, bromo, iodo, cyano or lower alkyl; and R2 represents a 4- to 8-membered heterocycle optionally substituted by lower alkyl, imino, hydroxy, hydroxymethyl, methanesulfonyloxy, amino or nitro and having one to three nitrogen atoms, amidinothio wherein hydrogen on nitrogen is optionally substituted by lower alkyl, guanidino wherein hydrogen on nitrogen is optionally substituted by lower alkyl or cyano, lower alkylamidino, amino wherein hydrogen on nitrogen is optionally substituted by lower alkyl, -CH¿2?N(R?a)Rb¿ (wherein R?a and Rb¿ are the same or different and each represents hydrogen or lower alkyl, or R?a and Rb¿ together with the nitrogen atom to which they are bonded may form pyrrolidine), -NH-(CH¿2?)m-Z (wherein Z represents amino wherein hydrogen on nitrogen is optionally substituted by lower alkyl, or cyano; and m is an integer of 0 to 3), -NR?c(CH¿2)m-OH (wherein Rc represents hydrogen or lower alkyl; and n is a natural number of 1 to 4), -X-Y (wherein X represents S or NH; and Y represents 2-imidazolin-2-yl, 2-imidazolyl, 1-methylimidazol-2-yl, 1,2,4-triasol-3-yl, 2-pyrimidyl or 2-benzimidazolyl optionally substituted by lower alkyl), or ureido or thioureido wherein hydrogen on nitrogen is optionally substituted by lower alkyl; and drugs containing the same, such as antitumor effect potentiators and antitumor agents.