公开(公告)号：EP2548568A2

公开(公告)日：2013-01-23

申请号：EP12188784.8

申请日：2006-07-10

申请人： IPSEN PHARMA

发明人： Dong, Zheng Xin ,  Moreau, Jacques-Pierre

IPC分类号： A61K38/04

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/665

摘要： The present invention is directed to compounds according to the formula (R 2 R 3 )-A 1 -c (A 2 -A 3 -A 4 -A 5 -A 6 -A 7 -A 8 -A 9 )-A 10 -R 1 , and pharmaceutically acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.

摘要翻译： 本发明涉及作为配体的根据式（R2R3）-A1-c（A2-A3-A4-A5-A6-A7-A8-A9）-A10-R1的化合物及其药学上可接受的盐， 一种或多种黑皮质素受体，使用此类化合物治疗哺乳动物的方法以及包含所述化合物的药物组合物。

公开(公告)号：EP2296687A4

公开(公告)日：2012-12-26

申请号：EP09746943

申请日：2009-05-12

申请人： IPSEN PHARMA SAS

发明人： DONG ZHENG XIN ,  ZHANG JUNDONG

IPC分类号： A61K38/31

CPC分类号： A61K38/31

公开(公告)号：EP2523653A2

公开(公告)日：2012-11-21

申请号：EP11701938.0

申请日：2011-01-11

申请人： Ipsen Pharma S.a.S.

发明人： MONTES, Martin ,  LOUGHMAN, Thomas Ciaran ,  ROUME, Chantal ,  CHERIF-CHEIKH, Roland

IPC分类号： A61K9/00 ,  A61K38/31 ,  A61K9/19 ,  A61K47/12

CPC分类号： A61K38/08 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/12 ,  A61K38/31 ,  A61K47/12

摘要： The invention relates to a process for the preparation of injectable pharmaceutical compositions for the sustained release of somatostatin analogues and to pharmaceutical compositions prepared according to the process. In a preferred aspect the process comprises the steps of combining lanreotide acetate and acetic acid, lyophilizing the resulting mixture only once, and hydrating the lyophilizate. Acetic acid may be added to a desired pH during the final step of the process.

公开(公告)号：EP2400978A4

公开(公告)日：2012-10-03

申请号：EP10744071

申请日：2010-02-19

申请人： IPSEN PHARMA SAS

发明人： DONG ZHENG XIN

IPC分类号： A61K38/16 ,  A61K38/22

CPC分类号： A61K38/2271

公开(公告)号：EP2501225A1

公开(公告)日：2012-09-26

申请号：EP10830850.3

申请日：2010-11-15

申请人： Ipsen Pharma S.a.S.

发明人： DONG, Zheng Xin ,  ZHANG, Jundong

IPC分类号： A01N25/00

CPC分类号： A61K38/33 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/08 ,  A61K38/34 ,  C07K14/68 ,  C07K14/69

摘要： The present invention relates to improvements in compositions containing peptides that are ligands of one or more of the melanocortin receptors (MC-R), or pharmaceutically acceptable salts thereof, methods for preparing such compositions, and method of using such compositions to treat mammals. In particular, the present invention relates to a pharmaceutical composition comprising a pamoate salt of Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH
2 which is a ligand of the melanocortin receptor subtype 4 (MC4-R), and in which, after subcutaneous or intramuscular administration to a subject, the peptide forms a depot at physiological pH that is slowly dissolved and released into the body fluid and bloodstream. The present invention may further comprise an organic component such as dimethylacetamide (DMA) or polyethylene glycol (PEG) with an average molecular weight of lower than 1000.

摘要翻译： 本发明涉及一种在含有对一种或多种黑皮质素受体的（MC-R）的配体的肽的组合物的改进，或它们的药学上可接受的盐，用于制备这样的组合物，和使用这样的组合物治疗哺乳动物的方法的方法。 特别地，本发明涉及包含交流基-Arg-环的双羟萘酸盐（CYS-d-ALA-的His-d-苯丙氨酸 - 精氨酸 - 色氨酸 - 半胱氨酸）的药物组合物-NH 2，其是黑皮质素的配体 受体亚型4（MC4-R），并且其中在对受试者进行皮下或肌内给药后，所述肽在生理pH下形成贮库，其缓慢溶解并释放到体液和血流中。 本发明可以进一步包含有机组分，例如平均分子量低于1000的二甲基乙酰胺（DMA）或聚乙二醇（PEG）。

公开(公告)号：EP2236151B1

公开(公告)日：2012-05-23

申请号：EP10170694.3

申请日：2006-07-10

申请人： IPSEN PHARMA

发明人： Dong, Zheng Xin ,  Moreau, Jacques-Pierre

IPC分类号： A61K38/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/665

摘要： The present invention is directed to a compound according to the formula: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ Ac-Arg-c(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH 2 and pharmaceutically-acceptable salts thereof. This compound acts as a ligand for one or more of the melanocortin receptors. The invention also relates to methods of using this compound to treat mammals and to pharmaceutical compositions comprising said compound.

公开(公告)号：EP2396311A2

公开(公告)日：2011-12-21

申请号：EP10707096.3

申请日：2010-02-12

申请人： IPSEN PHARMA S.A.S.

发明人： MONDOLY, Nathalie ,  POIROT, Bertrand ,  BROCHARD, Anne ,  RICHARD, Joël ,  DELAHAYE, Delphine ,  DIOLEZ, Christian ,  ROLLAND, Alain ,  DIANCOURT, Francis ,  COQUEREL, Gérard ,  MARTINS, Damien ,  LINOL, Julie ,  HOUSSIN, Ophélie ,  PETIT, Marie-Noêlle ,  POTTER, Barry, Victor, Lloyd ,  WOO, Lok, Wai, Lawrence

IPC分类号： C07D311/94 ,  A61K31/352 ,  A61K31/353 ,  C07D311/78 ,  A61P35/00

CPC分类号： C07D311/78 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K31/353 ,  A61K31/37 ,  C07D311/94

摘要： The present invention relates to a solid pharmaceutical composition including the active principle 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate. The present invention also relates to polymorphs of the 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate compound.

公开(公告)号：EP1290062B1

公开(公告)日：2011-10-12

申请号：EP01934071.0

申请日：2001-05-10

申请人： IPSEN PHARMA ,  Centre National de la Recherche Scientifique - CNRS

发明人： DUMITRESCU, Anca ,  GORNITZKA, Heinz ,  MARTIN-VACA, Blanca ,  BOURISSOU, Didier ,  BERTRAND, Guy ,  CAZAUX, Jean-Bernard

IPC分类号： C08G65/26 ,  C08G63/82 ,  C08G65/12 ,  B01J31/12

CPC分类号： C08G65/2642 ,  B01J31/0212 ,  B01J31/0252 ,  B01J31/0274 ,  C08G63/823 ,  C08G65/12

摘要： The invention concerns the use of stannylenes and germylenes of general formula (1) wherein: M represents a tin or germanium atom; L1 and L2 independently represent a group of formula: -E14(R14)(R'14)(R''14), -E15(R15)(R'15) or -E16(R16), or together form a chain of formula -L'1-A-L'2; A represents a saturated or unsaturated chain comprising one, two or three elements of group 14; L'1 and L'2, represent, independently, a group of formula: -E14(R14)(R'14)-, E15(R15)- or -E16-; E14 is an element of group 14; E15 is an element of group 15; E16 is an element of group 16; R14, R'14, R''14, R15, R'15 and R16 represent variable groups as polymerisation catalysts of heterocycles.

公开(公告)号：EP2104510B1

公开(公告)日：2011-09-21

申请号：EP07872380.6

申请日：2007-12-17

申请人： IPSEN PHARMA S.A.S.

发明人： Favre, Christine ,  Auguet, Michel ,  Chabrier De Lassauniere, Pierre-Etienne

IPC分类号： A61K38/48 ,  A61P29/00

CPC分类号： A61K38/4893 ,  Y02A50/469

摘要： The invention relates to the use of at least one botulism neurotoxin for the production of a medicament for treating or preventing the pain induced by a medicament used to treat the AIDS virus.

公开(公告)号：EP2318433A2

公开(公告)日：2011-05-11

申请号：EP09805295.4

申请日：2009-08-07

申请人： IPSEN PHARMA S.A.S.

发明人： DONG, Zheng, Xin

IPC分类号： C07K14/62 ,  C07K14/46

CPC分类号： C07K14/001 ,  A61K38/00 ,  A61K38/16 ,  A61K47/60 ,  C07K14/605

摘要： There is provided a novel series of analogues of glucose-dependent insulinotropic polypeptide, pharmaceutical compositions containing said compounds, and the use of said compounds as GIP- receptor agonists or antagonists for treatment of GIP -receptor mediated conditions, such as non- insulin dependent diabetes mellitus and obesity.