公开(公告)号：EP1299043B1

公开(公告)日：2005-11-30

申请号：EP01945581.5

申请日：2001-06-25

申请人： Mor-Research Applications Ltd. ,  Cleanetica Ltd.

发明人： HAR-SHAI, Yaron ,  AMAR, Micha

IPC分类号： A61B18/02

CPC分类号： A61B18/02 ,  A61B2017/00747 ,  A61B2018/0262 ,  A61B2018/0293

摘要： An intralesional method for treating a hypertrophic scar or keloid using a cryoprobe. The method comprises: (a) inserting the cryoprobe into the hypertrophic scar or keloid so that the cryoprobe is positioned within the hypertrophic scar or keloid; and (b) introducing a cryogen into the cryoprobe thereby freezing the hypertrophic scar or keloid. The cryoprobe has a sealed distal end comprising a cutting tip. Also disclosed is a cryoprobe comprising an elongated, uninsulated housing having a sealed distal end and a proximal end. The housing comprises therein a cryogen inlet tube. The cryoprobe further comprises a cutting tip at the distal end of the housing and a cryogen vent adjacent to the proximal end and in fluid communication with the interior of the housing.

公开(公告)号：EP1539023A2

公开(公告)日：2005-06-15

申请号：EP03766601.3

申请日：2003-07-31

申请人： Yissum Research Development Company,of The Hebrew University of Jerusalem ,  MOR RESEARCH APPLICATIONS LTD. ,  Ramot at Tel Aviv University Ltd.

发明人： ATLAS, Daphne ,  MELAMED, Eldad ,  OFFEN, Daniel

IPC分类号： A61C8/00

CPC分类号： A61K31/56 ,  A61K31/00 ,  A61K31/16 ,  A61K31/198 ,  A61K31/22 ,  A61K31/221 ,  A61K31/223 ,  A61K38/05 ,  A61K38/06 ,  A61K38/063

摘要： A method of treating multiple sclerosis, the method comprises administering to a subject in need thereof a therapeutically effective amount of a compound, the compound having: (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.

公开(公告)号：EP1242070A2

公开(公告)日：2002-09-25

申请号：EP00983467.2

申请日：2000-12-26

申请人： YISSUM RESEARCH DEVELOPMENT COMPANYOF THE HEBREW UNIVERSITY OF JERUSALEM ,  Mor-Research Applications Ltd. ,  RAMOT UNIVERSITYAUTHORITY FOR APPLIED RESEARCH& INDUSTRIAL DEVELOPMENT LTD.

发明人： ATLAS, Daphne ,  MELAMED, Eldad ,  OFFEN, Daniel

IPC分类号： A61K31/225 ,  A61K31/22 ,  A61K31/195

CPC分类号： A61K38/063 ,  A61K31/00 ,  A61K31/16 ,  A61K31/198 ,  A61K31/216 ,  A61K31/223 ,  A61K38/05 ,  C07C323/59 ,  C07K5/0215

摘要： A method of reducing oxidative stress in the brain of an organism having a blood brain barrier and suffering an ischemic brain injury, the method comprising the step of administering a compound to the organism, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.

公开(公告)号：EP1172654A1

公开(公告)日：2002-01-16

申请号：EP00114788.3

申请日：2000-07-10

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts ,  MOR RESEARCH APPLICATIONS LTD.

发明人： Altevogt, Peter ,  Fogel, Mina

IPC分类号： G01N33/574 ,  G01N33/68 ,  A61K39/395 ,  A61K38/17 ,  G01N33/577

CPC分类号： G01N33/57449 ,  G01N33/57442 ,  G01N2333/70503 ,  G01N2333/70596

摘要： A method is described for the diagnosis of an ovarian or endometrial tumor or for a prognosis, characterized in that the L1 level is determined in a patient sample, preferably via an anti L1 antibody, the presence of L1 being an indication of the presence of an ovarian or endometrial tumor or a predisposition for such a tumor.

摘要翻译： 描述了一种方法用于卵巢癌或子宫内膜肿瘤的诊断或预后，其特征DASS死L1水平是确定性的开采患者样品中，优选在通过抗L1抗体，L1的存在下的存在的指示 卵巢或子宫内膜肿瘤或肿瘤寻求倾向。

公开(公告)号：EP1165616A1

公开(公告)日：2002-01-02

申请号：EP99973801.6

申请日：1999-09-30

申请人： MOR-RESEARCH APPLICATIONS LTD.

发明人： HARDY, Britta ,  NOVOGRODSKY, Abraham

IPC分类号： C07K16/18 ,  C07K16/28 ,  C07K7/04 ,  A61K39/395 ,  A61K38/04 ,  G01N33/574 ,  C12N5/12 ,  C12N5/16 ,  C12N15/13 ,  C12N15/63

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K2039/505 ,  C07K7/08 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00 ,  G01N33/56972 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57434

摘要： The invention concerns novel DNA and amino acid sequences of monoclonal antibodies (mAbs) raised against lymphoblastoid cells and peptides to which the mAbs bind to. The invention also concerns diagnostic assays using said antibodies or peptides for detecting individuals with a high probability of having a malignant disease and, at times, for detecting an individual having a specific malignant disease. The invention further concerns pharmaceutical compositions comprising the mAbs or peptides of the invention for use in the treatment of various malignant diseases as well as methods for the treatment of malignant diseases using the mAbs or peptides of the invention.

公开(公告)号：EP1067955A2

公开(公告)日：2001-01-17

申请号：EP99912039.7

申请日：1999-03-30

申请人： YEDA RESEARCH AND DEVELOPMENT Co. LTD. ,  Mor-Research Applications Ltd.

发明人： HARAN-GHERA, Nechama ,  MITTELMAN, Moshe ,  PELED, Alpha

IPC分类号： A61K38/18

CPC分类号： A61K38/1816

摘要： Pharmaceutical compositions comprising erythropoietin are provided for treatment of cancer, particularly for treatment of muliple myeloma. Erythropoietin was found to be effective for inhibition of tumor growth, triggering of tumor regression, stimulation of the natural immunological defense against cancer and/or inhibition of cancer cell metastasis.

公开(公告)号：EP0998278A1

公开(公告)日：2000-05-10

申请号：EP98911574.6

申请日：1998-03-11

申请人： BAR-ILAN UNIVERSITY ,  MOR RESEARCH APPLICATIONS LTD.

发明人： NUDELMAN, Abraham ,  REPHAELI, Adi

IPC分类号： A61K31/22 ,  A61K31/235 ,  C07C69/02 ,  C07C69/612

CPC分类号： C07C69/708 ,  C07C69/96

摘要： This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating blood disorders such as anemias, immunomodulation, enhancing recombinant gene expression, treating insulin-dependent patients, treating cystic fibrosis patients, inhibiting telomerase activity, treating virus-associated tumors, especially EBV-associated tumors, augmenting expression of tumor suppressor genes, inducing tolerance to antigens, or treating, preventing or ameliorating protozoan infection or inhibiting histone deacetylase in cells. The compositions of the invention are to and the methods of the invention use hydroxy and ether-containing oxyalkylene esters.

公开(公告)号：EP3697409A1

公开(公告)日：2020-08-26

申请号：EP18868640.6

申请日：2018-10-18

申请人： Mor Research Applications Ltd.

发明人： BEN-SHALOM, Noach ,  ROBINSON, Dror

IPC分类号： A61K31/352 ,  A61K31/722 ,  A61P3/06

公开(公告)号：EP3589237A1

公开(公告)日：2020-01-08

申请号：EP18760833.6

申请日：2018-03-01

申请人： Mor Research Applications Ltd.

发明人： OMER, Gonen ,  MAHLER, Ori

IPC分类号： A61F2/16 ,  G02C7/16 ,  G02C7/00

公开(公告)号：EP3328292A1

公开(公告)日：2018-06-06

申请号：EP16832425.9

申请日：2016-08-02

申请人： Mor Research Applications Ltd.

发明人： IGOV, Igor

IPC分类号： A61B17/00

CPC分类号： A61F2/0063 ,  A61B17/0401 ,  A61B17/064 ,  A61B17/0682 ,  A61B17/122 ,  A61B17/1285 ,  A61B2017/00477 ,  A61B2017/00867 ,  A61B2017/00876 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0427 ,  A61B2017/0464 ,  A61F2002/0072 ,  A61F2220/0016

摘要： A system comprising an elongated mesh deployment tool having a proximal tool part and a distal tool part. The system comprises one or more wires for coupling a surgical mesh with the distal tool part, where the wires are coupled to the surgical mesh and the distal tool part in one or more locations. The distal tool part is configured for deploying the surgical mesh at a hernia location, where the deploying is performed by pulling the one or more wires in a proximal direction to mount the surgical mesh in a spread configuration near the hernia location.