专利检索 ap:("YISSUM RESEARCH DEVELOPMENT COMPANYOF THE HEBREW UNIVERSITY OF JERUSALEM" OR "Mor-Research Applications Ltd." OR "RAMOT UNIVERSITYAUTHORITY FOR APPLIED RESEARCH& INDUSTRIAL DEVELOPMENT LTD.") AND inv:"MELAMED, Eldad" 第 1 页

1.

发明公开
TREATMENT OF ISCHEMIC BRAIN INJURIES WITH BRAIN TARGETTED ANTIOXIDANT COMPOUNDS 审中-公开
标题翻译：缺血性脑损伤脑靶向抗氧化剂治疗

公开(公告)号：EP1242070A2

公开(公告)日：2002-09-25

申请号：EP00983467.2

申请日：2000-12-26

申请人： YISSUM RESEARCH DEVELOPMENT COMPANYOF THE HEBREW UNIVERSITY OF JERUSALEM , Mor-Research Applications Ltd. , RAMOT UNIVERSITYAUTHORITY FOR APPLIED RESEARCH& INDUSTRIAL DEVELOPMENT LTD.

发明人： ATLAS, Daphne , MELAMED, Eldad , OFFEN, Daniel

IPC分类号： A61K31/225 , A61K31/22 , A61K31/195

CPC分类号： A61K38/063 , A61K31/00 , A61K31/16 , A61K31/198 , A61K31/216 , A61K31/223 , A61K38/05 , C07C323/59 , C07K5/0215

摘要： A method of reducing oxidative stress in the brain of an organism having a blood brain barrier and suffering an ischemic brain injury, the method comprising the step of administering a compound to the organism, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.

2.

发明公开
BRAIN TARGETED LOW MOLECULAR WEIGHT HYDROPHOBIC ANTIOXIDANT COMPOUNDS 失效
标题翻译：对大脑的前瞻性低分子抗氧化疏水性化合物

公开(公告)号：EP0948258A1

公开(公告)日：1999-10-13

申请号：EP97952665.0

申请日：1997-12-23

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , MOR RESEARCH APPLICATIONS LTD.

发明人： ATLAS, Daphne , MELAMED, Eldad

IPC分类号： A61K31 , C07C323 , C07K5 , A61K38

CPC分类号： A61K31/223 , A61K31/16 , A61K31/198 , A61K38/00 , C07C323/59 , C07K5/0215

摘要： Novel brain targeted low molecular weight, hydrophobic antioxidants and use of antioxidants in treatment of central nervous system neurodegenerative disorders such as Parkinson's, Alzheimer's and Creutzfeldt-Jacob's diseases and in treatment of conditions of peripheral tissues, such as acute respiratory distress syndrome, amyotrophic lateral sclerosis, atherosclerotic cardiovascular diseases and multiple organ dysfunction, in which oxidants are overproduced.

3.

发明公开
TREATMENT OF DYSKINESIAS 审中-公开
标题翻译：治疗运动障碍

公开(公告)号：EP1043996A2

公开(公告)日：2000-10-18

申请号：EP99900116.7

申请日：1999-01-05

申请人： MOR-RESEARCH APPLICATIONS LTD.

发明人： MELAMED, Eldad , DJALDETTI, Ruth , ZIV, Ilan

IPC分类号： A61K31/425

CPC分类号： A61K31/428 , A61K31/195 , A61K31/425 , A61K2300/00

摘要： Levodopa-induced dyskinesia and tardative dyskinesia are ameliorated by administration of riluzole to needing subjects.

4.

发明公开
TREATMENT OF MULTIPLE SCLEROSIS WITH BRAIN TARGETED ANTI OXIDANT COMPOUNDS 审中-公开
标题翻译：多发性硬化与大脑旨在抗氧化化合物的治疗

公开(公告)号：EP1539023A2

公开(公告)日：2005-06-15

申请号：EP03766601.3

申请日：2003-07-31

申请人： Yissum Research Development Company,of The Hebrew University of Jerusalem , MOR RESEARCH APPLICATIONS LTD. , Ramot at Tel Aviv University Ltd.

发明人： ATLAS, Daphne , MELAMED, Eldad , OFFEN, Daniel

IPC分类号： A61C8/00

CPC分类号： A61K31/56 , A61K31/00 , A61K31/16 , A61K31/198 , A61K31/22 , A61K31/221 , A61K31/223 , A61K38/05 , A61K38/06 , A61K38/063

摘要： A method of treating multiple sclerosis, the method comprises administering to a subject in need thereof a therapeutically effective amount of a compound, the compound having: (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the organism; (b) a readily oxidizable chemical group for exerting antioxidation properties; and (c) a chemical make-up for permitting the compound or its intracellular derivative to accumulate within the cytoplasm of cells.