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公开(公告)号：EP0619322B1
公开(公告)日：2005-12-28
申请号：EP94300981.1
申请日：1994-02-10
申请人： SCIOS INC.
发明人： Danley, Dennis Edward , Gelfand, Robert Alan , Geoghegan, Kieran Francis , Yesook, Kim , Lambert, William Joseph , Hong, Qi
IPC分类号： C07K14/605 , A61K38/26 , A61P3/10
CPC分类号： C07K14/605 , A61K38/00
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72.发明公开Treatment of diseases involving cyst formation with combinations comprising a PTBR agonist 审中-公开白痴on on en en mit mit mit mit end end end end end end end
公开(公告)号：EP1607744A2
公开(公告)日：2005-12-21
申请号：EP05016779.0
申请日：1999-12-15
申请人： SCIOS INC.
IPC分类号： G01N33/68 , C12Q1/68 , C07K14/475 , A61K45/06 , A61K38/21 , A61K31/5513 , A61P13/12 , A61P43/00
CPC分类号： A61K31/5513 , A61K38/191 , A61K45/06 , G01N33/948 , A61K2300/00
摘要： The invention concerns the use of ligands of peripheral-type benzodiazepine receptors (PTBR) in the diagnosis and treatment of diseases involving cyst formation and in particular polycystic kidney disease. The invention further concerns the treatment of hypertension accompanying polycystic kidney disease, and pharmaceutical compositions and articles of manufacture for the treatment of diagnosis of the target disease or condition.
摘要翻译： 本发明涉及外周型苯二氮类受体（PTBR）的配体在诊断和治疗涉及囊肿形成，特别是多囊肾病的疾病中的用途。 本发明还涉及治疗伴随多囊肾病的高血压，以及用于治疗目标疾病或病症的诊断的药物组合物和制品。
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公开(公告)号：EP1549316A1
公开(公告)日：2005-07-06
申请号：EP03754501.9
申请日：2003-09-10
申请人： SCIOS INC.
IPC分类号： A61K31/505 , A61K31/506 , A61K31/53 , C07D239/32 , C07D251/14 , C07D403/12
CPC分类号： C07D409/14 , C07D239/42 , C07D401/12 , C07D405/14 , C07D413/14
摘要： Certain appropriately substituted forms of pyrimidine and triazine are useful in the treatment to conditions associated with enhanced TGFβ activity.
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公开(公告)号：EP1545528A2
公开(公告)日：2005-06-29
申请号：EP03749429.1
申请日：2003-09-03
申请人： SCIOS INC.
发明人： CHAKRAVARTY, Sarvajit , DUGAR, Sundeep , LU, Qing , LUEDTKE, Gregory, R. , MAVUNKEL, Babu, J. , PERUMATTAM, John, Joseph , TESTER, Richland
IPC分类号： A61K31/496 , A61K31/454 , C07D401/10 , C07D403/10 , C07D409/14
CPC分类号： C07D401/06 , C07D209/18 , C07D209/42 , C07D401/14 , C07D403/06 , C07D409/12 , C07D409/14
摘要： The invention is directed to methods to inhibit p38-α kinase using compounds comprising a phenyl or thienyl coupled through a piperidine or piperazine nucleus to an indole residue wherein the indole residue mandatorily has a substituent on the ring nitrogen which is an amino or substituted amino group.
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75.发明公开
公开(公告)号：EP1511738A1
公开(公告)日：2005-03-09
申请号：EP03726892.7
申请日：2003-05-16
申请人： Scios Inc.
发明人： CHAKRAVARTY, Sarvajit , DUGAR, Sundeep , HIGGINS, Linda, S. , KAPOUN, Ann, M. , LIU, David, Y. , SCHREINER, George, F. , PROTTER, Andrew, A. , TRAN, Thomas-Toan
IPC分类号： C07D239/42 , C07D239/94 , C07D471/04
CPC分类号： A61K31/435 , A61K31/495 , A61K31/53
摘要： The invention concerns methods of treating fibroproliferative disorders associated with TGF-β signaling, by administering non-peptide small molecule inhibitors of TGF-β specifically binding to the type I TGF-β receptor (TGFβ-R1). Preferably, the inhibitors are quinazoline derivatives. The invention also concerns methods for reversing the effect of TGF-β mediated cell activation on the expression of a gene associated with fibrosis, comprising contacting a cell or tissue in which the expression of such gene is altered as a result of TGF-β mediated cell activation, with a non-peptide small molecule inhibitor of TGF-β, specifically binding a TGFβ-R1 receptor kinase present in the cell or tissue.
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76.发明公开Use of an angiogenic factor for the treatment of microvascular angiopathies 审中-公开使用血管生成因子的微血管血管病变的治疗
公开(公告)号：EP1417971A3
公开(公告)日：2004-06-30
申请号：EP03025732.3
申请日：1999-09-09
IPC分类号： A61K38/19 , A61K48/00 , A61K39/395 , A61P9/00
CPC分类号： A61K38/1858
摘要： The invention concerns the prevention and treatment of endothelial injury and the injury of tissues containing injured blood vessels by administration of angiogenic factors, such as vascular endothelial cell growth factor (VEGF).
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77.发明公开
公开(公告)号：EP1417971A2
公开(公告)日：2004-05-12
申请号：EP03025732.3
申请日：1999-09-09
IPC分类号： A61K38/19 , A61K48/00 , A61K39/395 , A61P9/00
CPC分类号： A61K38/1858
摘要： The invention concerns the prevention and treatment of endothelial injury and the injury of tissues containing injured blood vessels by administration of angiogenic factors, such as vascular endothelial cell growth factor (VEGF).
摘要翻译： 本发明涉及通过施用血管生成因子诸如血管内皮细胞生长因子（VEGF）来预防和治疗内皮损伤和包含受损血管的组织的损伤。
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公开(公告)号：EP1109571B1
公开(公告)日：2004-03-03
申请号：EP99968631.4
申请日：1999-09-09
IPC分类号： A61K38/19 , A61K39/395 , A61P9/00 , G01N33/50
CPC分类号： A61K38/1866 , A61K48/00
摘要： The present invention provides methods and compositions for treating hypertension. The methods generally involve administering a factor which increases angiogenesis and/or vascular permeability. Compositions for use in the methods are also provided.
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公开(公告)号：EP0970379B1
公开(公告)日：2003-11-12
申请号：EP98911801.3
申请日：1998-03-19
申请人： SCIOS INC.
CPC分类号： G01N33/6896 , G01N33/5088 , G01N2333/4709 , G01N2800/2821
摘要： The present invention provides methods that can be used to identify beta -amyloid reducing compounds. The present invention is based on the use of organotypic brain slice culturing methods to simultaneously access to toxicity and beta -amyloid reducing activity of a test compound.
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公开(公告)号：EP1220916A1
公开(公告)日：2002-07-10
申请号：EP00968431.7
申请日：2000-09-27
申请人： Scios Inc.
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/02 , Y02A50/411
摘要： The invention concerns a new secreted factor encoded by clone P00188_D12, and other mammalian homologues and variants of such factor, as well as polynucleotides encoding them. The invention further concerns methods and means for producing such factors and their use in the diagnosis and treatment of various cardiac, renal or inflammatory diseases.
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