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公开(公告)号：EP3436022B1
公开(公告)日：2022-03-09
申请号：EP17776839.7
申请日：2017-03-31
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公开(公告)号：EP2887944B1
公开(公告)日：2021-10-06
申请号：EP13830765.7
申请日：2013-08-21
发明人： REDDY, Kiran , KANES, Stephen Jay
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公开(公告)号：EP3250210B1
公开(公告)日：2020-12-02
申请号：EP16743932.2
申请日：2016-01-26
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公开(公告)号：EP3529257A1
公开(公告)日：2019-08-28
申请号：EP17794489.9
申请日：2017-10-18
发明人： SALITURO, Francesco G. , ROBICHAUD, Albert J. , MARTINEZ BOTELLA, Gabriel , HARRISON, Boyd L. , GRIFFIN, Andrew , LA, Daniel
IPC分类号： C07J9/00 , A61K31/575 , A61P25/28
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公开(公告)号：EP3481844A1
公开(公告)日：2019-05-15
申请号：EP17743137.6
申请日：2017-07-11
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公开(公告)号：EP3436022A1
公开(公告)日：2019-02-06
申请号：EP17776839.7
申请日：2017-03-31
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公开(公告)号：EP3426257A1
公开(公告)日：2019-01-16
申请号：EP17763984.6
申请日：2017-03-08
IPC分类号： A61K31/57 , A61K31/56 , A61K31/575 , A61K31/58
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公开(公告)号：EP3206494A4
公开(公告)日：2018-07-04
申请号：EP15851530
申请日：2015-10-16
IPC分类号： C07J43/00 , A01N51/00 , A61K31/575 , A61K31/58 , A61P23/00 , A61P25/08 , A61P25/20 , C07J1/00 , C07J3/00 , C07J5/00 , C07J7/00 , C07J9/00 , C07J11/00 , C07J13/00 , C07J21/00 , C07J31/00 , C07J41/00 , C07J51/00 , C07J71/00
CPC分类号： C07J43/003 , A61K31/575 , A61K31/58 , A61K45/06 , C07J1/0011 , C07J1/0022 , C07J3/005 , C07J5/0053 , C07J7/002 , C07J7/007 , C07J7/008 , C07J9/00 , C07J11/00 , C07J13/007 , C07J21/00 , C07J31/006 , C07J41/0066 , C07J51/00 , C07J71/001
摘要： Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein (II), A, R1, R2, R3a, R4a, R4b, R5, R7a, and R7b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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公开(公告)号：EP3191101A4
公开(公告)日：2018-04-11
申请号：EP15839264
申请日：2015-09-08
发明人： KANES STEPHEN JAY , COLQUHOUN HELEN
IPC分类号： A61K31/57 , A61K9/00 , A61K31/56 , A61K31/573 , A61K47/40 , A61P25/24 , C07J7/00 , C07J43/00
CPC分类号： A61K31/573 , A61K9/0019 , A61K9/0053 , A61K31/57 , A61K47/40
摘要： Described herein are methods of treating tremor, e.g., essential tremor; depression, e.g., postpostum depression; and anxiety disorder, the method comprising administering to a human subject suffering from tremor, e.g., essential tremor; depression, e.g., postpostum depression, an anxiety disorder with a neuroactive steroid or a composition comprising a neuroactive steroid (e.g., pregnanolone, allopregnanolone, alphadalone, ganaxolone, or alphaxolone).
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公开(公告)号：EP3250210A1
公开(公告)日：2017-12-06
申请号：EP16743932.2
申请日：2016-01-26
发明人： ROBICHAUD, Albert Jean , MARTINEZ BOTELLA, Gabriel , SALITURO, Francesco G. , HARRISON, Boyd L.
IPC分类号： A61K31/56
CPC分类号： A61K45/06 , A61K31/00 , A61K45/00 , C07J3/00 , C07J3/005 , C07J7/002 , C07J7/007 , C07J7/0085 , C07J7/009 , C07J9/00 , C07J13/007 , C07J41/0044 , C07J43/003 , C07J51/00
摘要： or a pharmaceutically acceptable salt thereof; wherein , A, R1, R2, and R3 are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use, e.g., for treating a subject suffering from a disease or disorder described herein.
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