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公开(公告)号：EP4275748A3
公开(公告)日：2024-01-03
申请号：EP23185790.5
申请日：2015-10-16
IPC分类号： C07D231/14 , C07D295/033 , A01N51/00 , A61P25/00 , C07J7/00
摘要： Described herein are neuroactive steroids of the Formula (I):
or a pharmaceutically acceptable salt thereof; wherein - - - - - - , R 1 , R 2a , R 2b , R 3 and A are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.-
公开(公告)号：EP3828194A1
公开(公告)日：2021-06-02
申请号：EP21151891.5
申请日：2016-07-06
IPC分类号： C07J9/00 , A61K31/566 , A61P25/00 , A61P1/04 , A61P3/10 , A61P25/20 , A61P35/00 , A61P43/00 , A61K31/575 , C07J7/00
摘要： Compounds are provided according to Formula (I):
and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R 1 , R 2 , R 3 , R 6 , R 7 , R 8 , and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.-
公开(公告)号：EP3319611A1
公开(公告)日：2018-05-16
申请号：EP16821924.4
申请日：2016-07-06
IPC分类号： A61K31/567 , A61K31/566
CPC分类号： A61K31/575 , C07J7/002 , C07J9/00 , C07J9/005
摘要： Compounds are provided according to Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R6, R7, R8, and n are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
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公开(公告)号：EP3206493A1
公开(公告)日：2017-08-23
申请号：EP15851053.7
申请日：2015-10-16
发明人： MARTINEZ BOTELLA, Gabriel , SALITURO, Francesco G. , ROBICHAUD, Albert Jean , HARRISON, Boyd L.
IPC分类号： A01N51/00
CPC分类号： C07J43/003 , A61K9/0019 , A61K9/0053 , A61K31/58 , A61P25/00 , C07D231/14 , C07D249/04 , C07D249/18 , C07D295/033
摘要： Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein, R1, R2a, R2b, R3and A are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
摘要翻译： 本文描述了式（I）的神经活性甾族化合物：或其药学上可接受的盐; 其中，R 1，R 2a，R 2b，R 3和A如本文所定义。 在某些实施方案中，这些化合物被设想用作GABA调节剂。 本发明还提供了包含本发明化合物的药物组合物以及使用和治疗方法，例如用于诱导镇静和/或麻醉的方法。
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公开(公告)号：EP4316591A3
公开(公告)日：2024-04-24
申请号：EP23199636.4
申请日：2016-07-06
IPC分类号： C07J9/00 , C07J31/00 , C07J41/00 , C07J51/00 , A61K31/567 , A61K31/566 , A61P25/00
CPC分类号： C07J9/00 , C07J31/006 , C07J41/0055 , C07J51/00 , Y02P20/582 , C07J9/005 , A61P1/00 , A61P25/00
摘要： Compounds are provided according to Formula (I):
and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein R1, R2, R3, R4, R5, and R8 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.-
公开(公告)号：EP4275748A2
公开(公告)日：2023-11-15
申请号：EP23185790.5
申请日：2015-10-16
IPC分类号： A61P25/00
摘要： Described herein are neuroactive steroids of the Formula (I):
or a pharmaceutically acceptable salt thereof; wherein - - - - - - , R 1 , R 2a , R 2b , R 3 and A are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.-
公开(公告)号：EP4144746A1
公开(公告)日：2023-03-08
申请号：EP22187660.0
申请日：2015-05-29
发明人： BOTELLA, Gabriel Martinez , HARRISON, Boyd L. , ROBICHAUD, Albert Jean , SALITURO, Francesco G. , BERESIS, Richard Thomas
摘要： Described herein is a compound of the formula:
for use in a method for treating essential tremor in a subject in need thereof comprising administering to the subject the compound. The present invention also provides a pharmaceutically acceptable salt of the compound of the present invention for use in: (i) a method for treating essential tremor in a subject in need thereof comprising administering to the subject the pharmaceutically acceptable salt of the compound or (ii) a method for treating essential tremor in a subject in need thereof comprising administering to the subject the composition.-
公开(公告)号：EP3909966A1
公开(公告)日：2021-11-17
申请号：EP21178047.3
申请日：2014-04-17
发明人： BOTELLA, Gabriel Martinez , HARRISON, Boyd L. , ROBICHAUD, Albert Jean , SALITURO, Francesco G. , BERESIS, Richard Thomas
IPC分类号： C07J43/00 , A61K31/57 , A61K31/573 , A61K31/58 , A61P25/00 , A61P9/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/28 , A61P25/30 , A61P27/16 , A61P25/14 , C07J3/00 , C07J7/00 , C07J15/00 , C07J1/00 , C07J5/00 , C07J13/00 , C07J21/00 , C07J31/00
摘要： According to the present application, there is provided the compound of the formula indicated herein or a pharmaceutically acceptable salt thereof in the treatment in humans of bipolar disorder, anxiety disorder, depression, tremor or tinnitus.
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公开(公告)号：EP3250210B1
公开(公告)日：2020-12-02
申请号：EP16743932.2
申请日：2016-01-26
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公开(公告)号：EP3250210A1
公开(公告)日：2017-12-06
申请号：EP16743932.2
申请日：2016-01-26
发明人： ROBICHAUD, Albert Jean , MARTINEZ BOTELLA, Gabriel , SALITURO, Francesco G. , HARRISON, Boyd L.
IPC分类号： A61K31/56
CPC分类号： A61K45/06 , A61K31/00 , A61K45/00 , C07J3/00 , C07J3/005 , C07J7/002 , C07J7/007 , C07J7/0085 , C07J7/009 , C07J9/00 , C07J13/007 , C07J41/0044 , C07J43/003 , C07J51/00
摘要： or a pharmaceutically acceptable salt thereof; wherein , A, R1, R2, and R3 are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use, e.g., for treating a subject suffering from a disease or disorder described herein.
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