公开(公告)号：EP0876170A1

公开(公告)日：1998-11-11

申请号：EP97904730.0

申请日：1997-01-07

申请人： MEDTRONIC, INC.

发明人： ELGAS, Roger, J. ,  COREY, Edmund R. Jr., Spring Mountain Summit ,  GREMEL, Robert, F. ,  HAMLEN, Robert, C.

IPC分类号： A61M1 ,  F28F21

CPC分类号： A61M1/1698 ,  A61M1/1625 ,  A61M1/1629 ,  A61M2205/366 ,  F28D2021/005 ,  F28F21/062

摘要： A generally cylindrical membrane-type fiber bundle blood oxygenator (10) concentrically surrounds a generally cylindrical blood heat exchanger. Heat transfer fluid flows downwardly from the upper end of the heat exchanger around outside surfaces of the fiber bundle (26). A blood inlet manifold (18) at the lower end of the heat exchanger includes an inlet nozzle (30) and a generally conical wall (60). A transition manifold (24) at the upper end of the heat exchanger directs blood to the upper end of the oxygenator fiber bundle (28). The transition manifold (24) includes a generally conical wall (96) defining a surface which spreads the blood substantially uniformly around the upper portion of the fiber bundle (28). The blood flows downwardly around outside surfaces of the fiber bundle (28) to a blood outlet manifold that collects the oxygenated blood. The blood outlet manifold comprises an annular blood collection chamber (110). A blood outlet nozzle (32) extends from the annular blood collection chamber (110).

公开(公告)号：EP0850087A1

公开(公告)日：1998-07-01

申请号：EP96927400.0

申请日：1996-08-12

申请人： MEDTRONIC, INC.

发明人： FRANCISCHELLI, David ,  GEALOW, Kendra, K. ,  HAMMARGREN, John ,  NEISZ, Johann, J.

IPC分类号： A61N1

CPC分类号： A61N1/36042 ,  A61N1/36585 ,  A61N1/3962

摘要： A cardiac assist device having circadian muscle stimulation. In particular the present invention operates in one of two states, either day mode or night mode. During the day mode, muscle stimulation and conditioning are performed according to a first schedule. During the night mode, muscle stimulation and conditioning are performed according to a second schedule. In addition, the night mode is only reached if the night mode is permitted, a set number of sensed beats are less than the night mode rate, and the time of day is nighttime. The night mode is interrupted if the night mode is turned off, the time of day is daytime, or a set number of beats are greater than the night rate. In short, the present invention provides for skeletal muscle stimulation at a less fatiguing level during the night than during the day.

公开(公告)号：EP0835153A1

公开(公告)日：1998-04-15

申请号：EP97916053.0

申请日：1997-03-18

申请人： MEDTRONIC, INC.

发明人： ECKER, Robert, M. ,  McCLURE, Lawrence, C. ,  WAHLSTRAND, John, D.

IPC分类号： A61B5 ,  A61N1

CPC分类号： A61N1/3702 ,  A61N1/36514

摘要： Method and apparatus for detecting pressure waves caused by movement of a body organ, transmitted through a catheter (18) to an implanted medical device employing a pressure wave transducer (32) mounted in relation to the proximal end (40) of the catheter (18). The system may also include a reference transducer (34) having the same pressure wave response characteristics as the pressure wave transducer (32) but isolated from the proximal connector end (40) for providing a reference signal including common mode pressure wave noise that both transducers (32, 34) are simultaneously subjected to. The pressure wave signal and the reference signal are preferably amplified, bandpass filtered, stored, telemetered out or used to trigger a device operation. The pressure and reference wave transducers (32, 34) preferably are piezoelectric crystal transduces or accelerometers in direct or indirect mechanical contact with the proximal connector end (40) of the catheter and is encapsulated from the body within a device connector assembly (20). Cardiac pressure waves and respiration pressure waves are both transmitted proximally through the lead body (18) to the pressure wave transducer (32). Pressure wave signals may be derived in parallel to detect particular characteristic of the cardiac and/or respiratory cycle to provide timing signal(s) for controlling the device operations.

公开(公告)号：EP0812223A1

公开(公告)日：1997-12-17

申请号：EP96906204.0

申请日：1996-01-26

申请人： MEDTRONIC, INC.

发明人： KIEVAL, Robert, S. ,  HESS, Michael, F.

IPC分类号： A61N1

CPC分类号： A61N1/3712 ,  A61N1/3627 ,  A61N1/3682

摘要： A dual chamber pacemaker is provided having capability for adjusting the AV escape interval so as to optimize the timing of delivered ventricular pace pulses for therapy of patients with cardiomyopathy. The pacemaker system continually monitors to determine when a delivered pace pulse results in a fusion beat, and periodically adjusts the AV escape interval in accordance with the percentage or rate of incidence of such fusion beats. In one specific embodiment, the pacing system determines the percentage of delivered ventricular pace pulses which are followed by fusion beats over a predetermined number of intervals, and decrements AV escape interval when such percentage is not below a predetermined minimum. The pacing system also periodically increments AV escape interval when the rate of fusion beats is acceptable, thereby providing a closed loop system for maintaining the AV interval at an optimally long value consistent with maximizing full capture by delivered ventricular pace pulses. In another embodiment, the V-V escape interval of a non-tracking mode pacemaker is controlled to optimize pre-excitation of the ventricle.

公开(公告)号：EP0762908A1

公开(公告)日：1997-03-19

申请号：EP96906586.0

申请日：1996-02-23

申请人： MEDTRONIC, INC.

发明人： SHELDON, Todd J.

IPC分类号： A61B5 ,  A61N1

CPC分类号： A61N1/36542 ,  A61N1/36535

摘要： A method of and apparatus for determining the physical posture of a patient's body, having a superior-inferior body axis, an anterior-posterior body axis and a lateral-medial body axis, in relation to earth's gravitational field. A medical device having first, second and, optionally, third DC accelerometers having sensitive axes mounted orthogonally within an implantable housing is adapted to be implanted with the sensitive axes generally aligned with the patient's body axes. Each DC accelerometer generates DC accelerometer signals having characteristic magnitudes and polarities on alignment of the sensitive axis with, against or normal to earth's gravitational field and DC accelerometer signals of varying magnitudes and polarities when not so aligned. Body position may be determined through comparison of the magnitudes and polarities of the DC accelerometer signals with the characteristic magnitudes and polarities. A patient activity signal may also be determined from the frequency of body movements recurring over a time unit effecting magnitude changes in the DC accelerometer signals within a certain range of magnitude and frequency. The activity and body position signals may be stored and/or used to monitor and effect the delivery of a therapy to the patient, e.g. by controlling the pacing rate of a rate responsive pacemaker.

公开(公告)号：EP0757577A1

公开(公告)日：1997-02-12

申请号：EP95913990.0

申请日：1995-03-08

申请人： MEDTRONIC, INC.

发明人： MARKOWITZ, Toby H. ,  HESS, Michael F. ,  SHELTON, Michael Brent ,  RIFF, Kenneth M. ,  JENSEN, Donald Nick

IPC分类号： A61N1

CPC分类号： A61N1/36514 ,  A61N1/365

摘要： Pacemaker with improved detection methods for occurrence of vasovagal syncope episodes. Increased rate pacing followed by fallback to lower rate is a retained feature. The lower rate need not be related to the increased pacing rate. One alternative detects stable or persistent rate below a threshold rate after a rapid rate drop through the threshold rate. Another alternative detects a 'top rate' as a highest persistent rate and compares the difference between it and the rate that follows a rate drop through a 'drop rate' or other threshold level. Yet another alternative finds a persistent rate above a first threshold rate before initiating the rate drop detection function. Once initiated, this embodiment preferably detects a rate drop from above said first threshold to below a second threshold rate, and also preferably detects a stable rate below said second threshold rate. Adaptations to avoiding pacing activation during sleep and combinations of the various embodiments are discussed.

公开(公告)号：EP0719163A1

公开(公告)日：1996-07-03

申请号：EP94925255.0

申请日：1994-08-10

申请人： MEDTRONIC, INC.

发明人： HUDRLIK, Terrence R.

IPC分类号： A61N1

CPC分类号： A61N1/36507 ,  A61N1/365 ,  A61N1/3704 ,  A61N1/371 ,  A61N1/3962

摘要： An apparatus for producing signals indicative of power levels of depolarizations of heart tissue, particularly adapted for use in an implantable anti-arrhythmia device or an implantable pacemaker. The device distinguishes between the power level of sensed depolarization signals in order to distinguish between different types of depolarization waveforms. In particular, the measured power level of the sensed depolarizations may be employed to distinguish between normally conducted and ectopic beats, for use in controlling the operation of an implantable anti-arrhythmia device such as an implantable pacemaker/cardioverter/defibrillator or for use in controlling the operation of a bradycardia pacemaker.

公开(公告)号：EP0711187A1

公开(公告)日：1996-05-15

申请号：EP94920094.0

申请日：1994-06-08

申请人： MEDTRONIC, INC.

发明人： BAETEN, Cor X. ,  CAMPS, Antoine

IPC分类号： A61N1

CPC分类号： A61N1/0587 ,  A61N1/36042

摘要： A method and apparatus for determining the optimum location for implanting a muscle stimulating electrode. A test probe is provided for producing an electric current at various muscle tissue locations to determine comparative threshold measurements of the selected muscle tissue locations and determine the optimum location for implanting the muscle stimulating electrode.

公开(公告)号：EP0705118A1

公开(公告)日：1996-04-10

申请号：EP94921181.0

申请日：1994-05-10

申请人： MEDTRONIC, INC.

发明人： SHELTON, Michael, B.

IPC分类号： A61N1 ,  H02J7

CPC分类号： A61N1/3708 ,  A61N1/378

摘要： An implantable cardiac pacemaker having programmable stimulating pulse amplitudes selectable by means of an external programming unit. The pacemaker includes charge pump circuitry for developing a stimulating pulse voltage on an output capacitor. The output capacitor is charged to a selected level identified by a multiple-bit amplitude value communicated to the implanted device from the external programmer. The pacemaker is also provided with circuitry for monitoring the depletion level of its battery and for generating an indicator signal when the battery has depleted beyond a predetermined level. Associated with the charge pump circuitry is a selectively activated comparator circuit for controlling the charging of the output capacitor. Prior to generation of the indicator signal, the charge pump circuitry remains deactivated for some programmed output amplitudes, the level of output capacitor charging being proportional to the battery voltage. After issuance of the indicator signal, the comparator circuit is activated to control the charging of the output capacitor. When the comparator circuit is activated for charging the capacitor, the resulting voltage established on the capacitor is proportional to a predetermined constant reference voltage. Longevity of the device is optimized by not activating the comparator circuit during early stages of battery depletion when the battery's output voltage is relatively stable.

公开(公告)号：EP0697984A1

公开(公告)日：1996-02-28

申请号：EP94915624.0

申请日：1994-05-19

申请人： GLENEAGLES SPRING WATERS COMPANY LIMITED

发明人： HAMILTON, John Stewart

IPC分类号： B65D23 ,  B65D81 ,  C02F1

CPC分类号： C02F1/505 ,  B65D81/28

摘要： In order to prevent bacteria in a container (1) for storing liquid for human consumption, the container or bottle (1) incorporates internally a deposit (3) of a material which destroys micro-organisms.