TISSUE PLUG
    73.
    发明公开
    TISSUE PLUG 有权
    GEWEBESTECKER

    公开(公告)号:EP2345433A4

    公开(公告)日:2013-12-25

    申请号:EP09819170

    申请日:2009-10-06

    申请人: 3 D MATRIX LTD

    摘要: There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like. The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a ²-structure in aqueous solution in the presence of physiological pH and/or a cation.

    摘要翻译: 提供了可应用于包括人在内的大型哺乳动物的生物可吸收肽组织闭塞剂,所述肽组织闭塞剂通过人工合成获得以避免病毒感染等问题。 所述组织闭塞剂含有肽,其中所述肽为具有8-200个氨基酸残基且亲水性氨基酸和疏水性氨基酸交替键合的两亲性肽,并且是在水溶液中呈现出2-结构的自组装肽 生理pH值和/或阳离子的存在。