公开(公告)号：EP3393536A1

公开(公告)日：2018-10-31

申请号：EP16880147.0

申请日：2016-12-23

申请人： Lifenet Health

发明人： QIN, Xiaofei ,  CHEN, Silvia ,  ASCHENBACH, Lindsey ,  CHEN, Jingsong

IPC分类号： A61L27/44 ,  A61L27/54 ,  A61L27/60 ,  A61L27/20 ,  A61L27/22 ,  A61P17/02

CPC分类号： A61L27/3687 ,  A61L27/3633 ,  A61L27/3691 ,  A61L27/54 ,  A61L27/60 ,  A61L2430/10 ,  A61L2430/34 ,  C12N5/0607 ,  C12N2533/90

摘要： A method of preparing a decellularized placental membrane is provided. The method comprises removing cells from a pre-decellularized placental membrane comprising an amnion layer and a chorion layer to produce a decellularized placental membrane without separating the amnion layer from the chorion layer. The pre-decellularized placental membrane is obtained from an amniotic sac, and the decellularized placental membrane comprises the amnion layer and the chorion layer. Also provided is a decellularized placental membrane and a placenta-derived graft comprising the decellularized placental membrane. Further provided are the uses of the decellularized placental membrane or the placenta-derived graft.

公开(公告)号：EP3365037A1

公开(公告)日：2018-08-29

申请号：EP16858318.5

申请日：2016-10-21

申请人： Indiana University Research & Technology Corporation

发明人： KOEHLER, Karl, R. ,  LEE, Jiyoon

IPC分类号： A61L27/38 ,  A61L27/60 ,  A61K35/36 ,  C12N5/071 ,  C12N5/074

CPC分类号： C12N5/0698 ,  A61K35/36 ,  A61L27/362 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/3687 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/3839 ,  A61L27/3891 ,  A61L27/3895 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2300/64 ,  A61L2430/34 ,  A61L2430/40 ,  C12N5/0606 ,  C12N5/0629 ,  C12N2501/155 ,  C12N2501/999 ,  C12N2506/03 ,  C12N2506/1346 ,  C12N2513/00 ,  C12N2533/76 ,  C12Q1/6876 ,  C12Q2600/136

摘要： Provided herein are methods for directing differentiation of human pluripotent stem cells into a three-dimensional multilayered skin composition comprising an epidermal layer, a dermal layer, and a plurality of cells capable of forming a functional hair follicle. Also provided herein are three-dimensional, multilayered engineered skin compositions and methods of using the same for drug screening, for screening compounds for effects on hair growth, and for other applications.

公开(公告)号：EP2289535B8

公开(公告)日：2018-08-08

申请号：EP10185372.9

申请日：2005-12-20

申请人： MUSC Foundation for Research Development

发明人： Gourdie, Robert ,  Ghatnekar, Gautam ,  Jourdan, Jane

IPC分类号： A61K38/08 ,  A61K38/10 ,  C07K5/10 ,  C07K7/06 ,  A61L31/08 ,  A61K45/06 ,  C07K14/435 ,  C07K14/47 ,  A61K38/07 ,  A61K38/17 ,  C07K7/08 ,  C07K14/705

CPC分类号： A61K38/177 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1709 ,  A61K38/1767 ,  A61K45/06 ,  A61L31/08 ,  A61L2430/34 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/43581 ,  C07K14/47 ,  C07K14/705 ,  C07K2319/01 ,  C07K2319/10

摘要： Provided herein are compositions and methods for use in promoting wound healing and tissue regeneration following tissue injury in a subject.

公开(公告)号：EP3337423A1

公开(公告)日：2018-06-27

申请号：EP16837727.3

申请日：2016-08-17

申请人： The Johns Hopkins University

发明人： MARTIN, Russell ,  REDDY, Sashank ,  SACKS, Justin ,  LI, Xiaowei ,  CHO, Brian, Honewee ,  MAO, Hai-quan

IPC分类号： A61F2/02 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58

CPC分类号： A61L27/48 ,  A61F2/0063 ,  A61F2/12 ,  A61F2210/0061 ,  A61F2250/0067 ,  A61L27/3633 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/129 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/64 ,  A61L2430/04 ,  A61L2430/34 ,  C08L5/08 ,  C08L89/00 ,  C08L67/04

摘要： The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

公开(公告)号：EP2964184B1

公开(公告)日：2018-05-09

申请号：EP14759906.2

申请日：2014-03-04

申请人： Dermelle, Llc D/b/a Eternogen, LLC

发明人： DEVORE, Dale, P. ,  BROOKS, Robert, J. ,  BYRNE, Todd

IPC分类号： A61K8/65 ,  A61Q19/08 ,  A61K8/34 ,  A61K8/60 ,  A61K8/44 ,  A61L27/24 ,  A61L27/34 ,  A61L27/50 ,  C08L89/06

CPC分类号： A61L27/24 ,  A61K8/345 ,  A61K8/60 ,  A61K8/65 ,  A61K2800/95 ,  A61L27/34 ,  A61L27/505 ,  A61L27/54 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C08L89/06

摘要： The present invention is directed to injectable acid soluble collagen compositions comprising a neutralized solution of an acid soluble collagen, EDTA and preferably a polyol, wherein the composition is injectable at physiological pH and the acid soluble collagen polymerizes upon exposure to tissue. The invention is suitable for use in soft tissue augmentation, promoting soft tissue regeneration and coating medical implants and devices.

公开(公告)号：EP3169372A4

公开(公告)日：2018-03-21

申请号：EP15821310

申请日：2015-07-17

申请人： UNIV CALIFORNIA

发明人： GRIFFIN DONALD R ,  WEAVER WESTBROOK ,  SEGURA TATIANA ,  DI CARLO DINO ,  SCUMPIA PHILIP

IPC分类号： A61L15/42 ,  A61L15/44 ,  A61L15/60 ,  A61L26/00 ,  A61L27/18 ,  A61L27/58

CPC分类号： A61L26/008 ,  A61L26/0019 ,  A61L26/0047 ,  A61L26/0066 ,  A61L26/0085 ,  A61L26/009 ,  A61L27/18 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/00 ,  A61L2430/34 ,  C08L71/02

摘要： A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

公开(公告)号：EP2968419B1

公开(公告)日：2018-03-14

申请号：EP14764291.2

申请日：2014-03-14

申请人： MIMEDX Group Inc.

发明人： KOOB, Thomas, J. ,  DENOZIERE, Guilhem ,  BROWN, Rebeccah, J.c.

IPC分类号： A61L27/36

CPC分类号： A61L27/3604 ,  A61L27/3695 ,  A61L2400/06 ,  A61L2430/34

摘要： Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.

公开(公告)号：EP3180042A4

公开(公告)日：2018-02-28

申请号：EP15831684

申请日：2015-08-17

申请人： THE JOHNS HOPKINS UNIV TECHNOLOGY VENTURES

发明人： JIANG XUESONG ,  REDDY SASHANK ,  BRANDACHER GERALD ,  MAO HAI-QUAN ,  SACKS JUSTIN ,  LI XIAOWEI ,  FENG KEVIN ,  MARTIN RUSSELL

IPC分类号： A61L27/26

CPC分类号： A61L27/52 ,  A61L27/16 ,  A61L27/18 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  A61L2400/06 ,  A61L2430/06 ,  A61L2430/34 ,  C08L5/08 ,  C08L67/04

摘要： A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

公开(公告)号：EP3280769A1

公开(公告)日：2018-02-14

申请号：EP16777116.1

申请日：2016-04-04

申请人： 3M Innovative Properties Company

发明人： LANGER-ANDERSON, Delony L. ,  GRIESGRABER, George W. ,  COLAK ATAN, Semra ,  PEREIRA, Junia ,  WLASCHIN, Katie F. ,  YOUNG, Alexi J. ,  ASMUS, Robert A. ,  KOHLER RIEDI, Petra L. ,  HAYS, David S. ,  RASMUSSEN, Jerald K. ,  SOLBERG, Michael J.

IPC分类号： C08L31/00

CPC分类号： A61L26/0066 ,  A61K9/7015 ,  A61K31/275 ,  A61K47/34 ,  A61L24/001 ,  A61L24/0015 ,  A61L24/043 ,  A61L24/06 ,  A61L26/00 ,  A61L26/0004 ,  A61L26/0019 ,  A61L26/0052 ,  A61L26/0061 ,  A61L26/0095 ,  A61L2300/404 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2430/34 ,  Y02A50/473 ,  C08L83/04

摘要： Film forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film forming polymer, a tackifier, and a volatile solvent. The film forming gels can also include antiseptics, cationic polymer coagulants, fillers, and other additives. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing.

公开(公告)号：EP2307065B1

公开(公告)日：2018-02-14

申请号：EP09774553.3

申请日：2009-07-02

申请人： ALLERGAN, INC.

发明人： VAN EPPS, Dennis, E.

IPC分类号： A61L27/18 ,  A61L27/38 ,  A61L27/58 ,  A61L26/00 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/50

CPC分类号： A61L27/48 ,  A61L27/3839 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/34 ,  G06Q40/12 ,  C08L89/06 ,  C08L5/08

摘要： Injectable compositions are provided, which include both a living cellular component and a filler component conducive to cell growth. The compositions are capable of providing both immediate tissue filling and long term tissue regeneration.