公开(公告)号：EP3800197A1

公开(公告)日：2021-04-07

申请号：EP20184807.4

申请日：2009-10-06

申请人： 3-D Matrix Ltd.

发明人： TAKAMURA, Kentaro ,  GOJO, Satoshi ,  KOBAYASHI, Satoru

IPC分类号： C07K7/08 ,  A61L17/00 ,  A61K38/08 ,  A61L31/00 ,  A61P7/04 ,  A61L31/04 ,  A61L31/14

摘要： There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like.
The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and/or a cation.

公开(公告)号：EP3708173A1

公开(公告)日：2020-09-16

申请号：EP18876388.2

申请日：2018-11-06

申请人： Hiroshima University ,  3-D Matrix Ltd.

发明人： TAHARA, Hidetoshi ,  KINEHARA, Masaki ,  YAMAMOTO, Yuki

IPC分类号： A61K31/7088 ,  A61K45/00 ,  A61K47/42 ,  A61K47/46 ,  A61P35/00 ,  A61P43/00 ,  C12N15/113

摘要： The object of the present invention is to find a pharmaceutical having strong cancer therapeutic effect. The present invention provides a pharmaceutical composition for cancer therapy comprising a transcription or processing product of a gene encoding a miRNA, wherein said miRNA is one or more miRNAs selected from the group consisting of miR-3140, miR-137, miR-631, and miR-657, pharmaceutical composition.

公开(公告)号：EP3219330B1

公开(公告)日：2019-11-13

申请号：EP15859435.8

申请日：2015-08-24

申请人： 3-D Matrix, Ltd. ,  Tokyo University of Science Foundation

发明人： OTSUKA, Hidenori ,  MATSUKUMA, Daisuke

IPC分类号： A61K47/42 ,  A61K47/34 ,  A61K47/36 ,  A61K38/00

公开(公告)号：EP3470093A1

公开(公告)日：2019-04-17

申请号：EP18181282.7

申请日：2009-10-06

申请人： 3-D Matrix Ltd.

发明人： TAKAMURA, Kentaro ,  GOJO, Satoshi ,  KOBAYASHI, Satoru

IPC分类号： A61L17/00 ,  A61K38/00 ,  A61L31/00 ,  A61P7/04 ,  A61L31/04 ,  A61L31/14

摘要： There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like.
The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and/or a cation.

公开(公告)号：EP3429645A1

公开(公告)日：2019-01-23

申请号：EP17720569.7

申请日：2017-03-17

申请人： 3-D Matrix, Ltd

发明人： KOBAYASHI, Satoru

IPC分类号： A61L24/00 ,  A61L24/10

公开(公告)号：EP3391897A1

公开(公告)日：2018-10-24

申请号：EP16875700.3

申请日：2016-12-14

申请人： 3-D Matrix Ltd.

发明人： NAGANO, Keiji ,  KOBAYASHI, Satoru

IPC分类号： A61K38/00 ,  A61K9/12 ,  A61L26/00 ,  A61P7/04 ,  A61P17/02 ,  A61P43/00 ,  C07K7/00

CPC分类号： A61K38/04 ,  A61K9/12 ,  A61K38/00 ,  A61L26/00 ,  A61P7/04 ,  A61P17/02 ,  C07K7/00

摘要： [Problem to be Solved]
It is intended to provide a composition for hemostasis which can be uniformly applied to a bleeding site and exerts a high hemostatic effect.
[Solution]
The present invention provides a composition to be applied as a spray to a subject, the spray being used for hemostasis, and the composition comprising a self-assembling peptide, wherein the self-assembling peptide self-assembles and thereby gels when the composition is applied to a bleeding site of the subject, and the self-assembling peptide is contained in the composition at a concentration at which the composition has an improved hemostatic ability as compared with that when directly applied.

公开(公告)号：EP3238749B1

公开(公告)日：2018-09-19

申请号：EP17152928.2

申请日：2009-10-06

申请人： 3-D Matrix Ltd.

发明人： TAKAMURA, Kentaro ,  GOJO, Satoshi ,  KOBAYASHI, Satoru

IPC分类号： A61L17/00 ,  A61K38/00 ,  A61L31/00 ,  A61P7/04 ,  A61L31/04 ,  A61L31/14

CPC分类号： A61K38/10 ,  A61K31/7004 ,  A61K31/7016 ,  A61K38/08 ,  A61K38/16 ,  A61L31/047 ,  A61L31/148 ,  A61L2400/04 ,  A61L2430/36 ,  C07K7/06 ,  C07K7/08

摘要： There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like. The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a ²-structure in aqueous solution in the presence of physiological pH and/or a cation.

公开(公告)号：EP3157453A4

公开(公告)日：2018-01-24

申请号：EP15809702

申请日：2015-06-19

申请人： 3-D MATRIX LTD ,  FORSYTH DENTAL INFIRMARY FOR CHILDREN

发明人： HASTURK HATICE ,  VAN DYKE THOMAS E ,  SPIRIO LISA

IPC分类号： A61L27/22 ,  A61C8/00 ,  A61C8/02 ,  A61L27/52

CPC分类号： A61C8/0092 ,  A61C8/0006 ,  A61C19/063 ,  A61L27/10 ,  A61L27/227 ,  A61L27/3865 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/12

摘要： Materials and methods for dental bone void filling such as during a sinus lift procedure are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. The peptide may undergo self-organization under physiological conditions and/or in the presence of a cation.

公开(公告)号：EP3116522A1

公开(公告)日：2017-01-18

申请号：EP15712231.8

申请日：2015-03-10

申请人： 3-D Matrix Ltd. ,  Mehta, Manav ,  Tsukada, Hisashi

发明人： MEHTA, Manav ,  TSUKADA, Hisashi ,  GIL, Eun, Seok ,  GILBERT, Karl, Patrick ,  KOBAYASHI, Satoru

IPC分类号： A61K38/10 ,  A61L31/04 ,  A61K9/00 ,  A61L26/00

CPC分类号： A61K38/07 ,  A61K2121/00 ,  A61L26/0047 ,  A61L26/008 ,  A61L2400/06

摘要： Materials and methods for treatment of pulmonary leakage are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary leakage.

摘要翻译： 提供了治疗肺部渗漏的材料和方法。 在溶液中含有约7个氨基酸和约32个氨基酸之间的肽可被引入到靶位点。 可以在目标部位设置水凝胶屏障，以便治疗肺部渗漏。

公开(公告)号：EP2750687A4

公开(公告)日：2015-03-18

申请号：EP12828087

申请日：2012-08-31

申请人： 3 D MATRIX LTD

发明人： KOBAYASHI SATORU ,  OKADA SATOSHI ,  TAKAMURA KENTARO

IPC分类号： A61K38/00 ,  A61P11/00

CPC分类号： A61K47/42 ,  A61K31/397 ,  A61K38/10

摘要： Provided are compounds and methods useful for sealing air leaks in the thoracic cavity. Compounds and compositions of the invention comprise certain amphiphilic peptides, 8-200 amino acid residues long, that self-assemble spontaneously to form a gel in the presence of physiological pH and/or in the presence of a cation. In one embodiment, the peptide comprises a repeated sequence arginine-alanine-aspartic acid-alanine (RADA). Methods of the invention include a method of occluding a pulmonary air leak in a subject, comprising applying a compound of the invention to the site of a pulmonary air leak. The compounds and methods of the invention can be combined with other agents useful to treat cancer, inflammation, or infection.

摘要翻译： 提供了用于密封胸腔漏气的化合物和方法。 本发明的化合物和组合物包含长达8-200个氨基酸残基的某些两亲肽，其在生理pH和/或阳离子存在下自发组装形成凝胶。 在一个实施方案中，肽包含重复序列精氨酸 - 丙氨酸 - 天门冬氨酸 - 丙氨酸（RADA）。 本发明的方法包括在受试者中闭塞肺部空气泄漏的方法，包括将本发明的化合物施用于肺部空气泄漏的部位。 本发明的化合物和方法可以与用于治疗癌症，炎症或感染的其它试剂组合。