CERVICAL CANCER ORGANOIDS
    73.
    发明公开

    公开(公告)号:EP3640324A1

    公开(公告)日:2020-04-22

    申请号:EP18200408.5

    申请日:2018-10-15

    IPC分类号: C12N5/071

    摘要: The present invention relates to a method for the production of a cervix epithelial cell organoid culture. By means of this method, an organoid culture of cervix epithelial cells, and a biobank comprising a plurality of different organoid cultures thereof may be generated. Further, a culture medium suitable for the long-term culture of epithelial stem cells is provided. Furthermore, the use of the organoid culture in the biobank for medical applications, e.g. in the field of diagnostics and therapy and in the fields of drug screening and immunotherapy is described.

    SNTIO3 MATERIAL, METHOD OF PREPARATION THEREOF, USE THEREOF AS FERROELECTRIC MATERIAL AND DEVICE COMPRISING A FERROELECTRIC MATERIAL

    公开(公告)号:EP3564188A1

    公开(公告)日:2019-11-06

    申请号:EP18170903.1

    申请日:2018-05-04

    IPC分类号: C01G23/00 G11C11/22

    摘要: The present invention relates to a material of the formula SnTiO 3 having a crystal structure comprised of layers, wherein the layers comprise Sn(II) ions, Ti(IV) ions and edge-sharing O 6 -octahedra, the edge-sharing O 6 -octahedra form a sub-layer, the Ti(IV) ions are located within 2/3 of the edge-sharing O 6 -octahedra, thus forming edge-sharing TiO 6 -octahedra, the edge-sharing TiO 6 -octahedra form a honeycomb structure within the sub-layer, the honeycomb structure comprising hexagons with Ti(IV)-vacancies within the hexagons, the Sn(II) ions are located above and below the Ti(IV)-vacancies with respect to the sub-layer, the Ti(IV) ions are optionally substituted with M, M is one or more elements selected from Group 4 and Group 14 elements, and the crystal structure satisfies at least one of the following features (i) and (ii):
    (i) the Sn(II) ions have a tetrahedral coordination sphere involving three O ions of the layer and the electron lone pair of the Sn(II) ions which is situated at an apical position relative to the three O ions of the layer,
    (ii) the layers are stacked so that each layer is translated relative to each adjacent layer by a stacking vector S1 or a stacking vector S2, the centers of adjacent hexagons form a parallelogram with a side having a length x and side having a length y, the stacking vector S1 is a combined translation along the side having the length x by 2/3 x and along the side having a length y by 1/3 y, the stacking vector S2 is a combined translation along the side having the length x by 1/3 x and along the side having a length y by 2/3 y, and the crystal structure comprises layers translated relative to adjacent layers by the stacking vector S1 and layers translated relative to adjacent layers by the stacking vector S2. The present invention is further directed to a material of the formula SnTiO 3 having a tetragonal perovskite-type crystal structure, a method for the preparation of SnTiO 3 , a device comprising a ferroelectric material and a use of the material of the formula SnTiO 3 in a ferroelectric element.