公开(公告)号：EP0950189A1

公开(公告)日：1999-10-20

申请号：EP97938110.0

申请日：1997-07-30

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

发明人： RAUSCHER, Frank, J., III. ,  JENSEN, David, E.

IPC分类号： C07K14 ,  C07K16 ,  A61K38

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K14/4703 ,  C07K16/18 ,  C07K2319/00

摘要： Nucleic acid and amino acid sequences of a BRCA1 Associated Protein, BAP-1, are provided. These sequences, the protein, and anti-BAP-1 antibodies are useful in therapeutics and diagnostics for cancers associated with loss of the 3p21 chromosomal region and/or inappropriate BAP-1 levels.

摘要翻译： 提供了BRCA1相关蛋白BAP-1的核酸和氨基酸序列。 这些序列，蛋白质和抗BAP-1抗体可用于治疗和诊断与3p21染色体区域丢失和/或不适当的BAP-1水平相关的癌症。

公开(公告)号：EP0389286B1

公开(公告)日：1996-07-10

申请号：EP90303108.6

申请日：1990-03-22

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

发明人： Plotkin, Stanley A. ,  Ricciardi, Robert P. ,  Gonczol, Eva

IPC分类号： A61K39/245 ,  C07K14/045 ,  C12N15/38

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2710/16122

公开(公告)号：EP0290246A3

公开(公告)日：1990-01-31

申请号：EP88304045.3

申请日：1988-05-05

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

发明人： Heber-Katz, Ellen ,  Dietzschold, Bernhard

IPC分类号： A61K39/205 ,  C07K7/00 ,  A61K37/02 ,  A61K39/385

CPC分类号： C07K14/005 ,  A61K9/127 ,  A61K9/1271 ,  A61K39/00 ,  A61K39/12 ,  A61K39/205 ,  A61K39/245 ,  A61K2039/5555 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/6018 ,  C12N2710/16634 ,  C12N2760/20122 ,  C12N2760/20134

摘要： Vaccines which generate an immunogenic T cell response protective against a rabies virus disease state, comprise an immunologically effective amount of (1) a peptide-­fatty acid conjugate, (2) a liposome composition and (3) an adjuvant. The conjugate (1) has the formula
where R′ and R˝ are alkyl groups containing 5 to 30 carbon atoms, and R‴ is selected from the group consisting of hydrogen and at least one amino acid residue, and X is an amino acid sequence corresponding to that of a peptide fragment derived from a protein of the virus which produces a T cell response, or a synthetic replica of said fragment.

公开(公告)号：EP0327363A2

公开(公告)日：1989-08-09

申请号：EP89301010.8

申请日：1989-02-02

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

发明人： Stamato, Thomas D. ,  Denko, Nicholas

IPC分类号： G01N27/26

CPC分类号： G01N27/44773

摘要： DNA molecules are separated by a gel electrophoresis method which employes alternating higher and lower strength, electric fields applied in opposite directions to a gel matrix containing DNA. The higher strength field is maintained for a shorter interval than the lower strength field, and the ratio of the product of the lower strength field and its pulse interval to the product of the higher strength field and its pulse interval is greater than 4:1 and sufficient to produce a net migration of the DNA molecules in the direction of the lower strength field.

摘要翻译： 通过凝胶电泳法分离DNA分子，该方法采用相对于含有DNA的凝胶基质相反方向施加交替的较高和较低强度的电场。 较高强度场保持较低强度场的较短的间隔，较低强度场与其脉冲间隔的乘积与高强度场与其脉冲间隔的乘积之比大于4：1， 足以产生DNA分子在较低强度场的方向上的净迁移。

公开(公告)号：EP0202005A1

公开(公告)日：1986-11-20

申请号：EP86302312.3

申请日：1986-03-27

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

发明人： Ross, Alonzo H. ,  Koprowski, Hilary ,  Herlyn, Meenhard

IPC分类号： G01N33/574 ,  A61K39/395 ,  C12N5/00

CPC分类号： C07K16/2863 ,  A61K38/00 ,  C07K16/3053 ,  G01N33/5743 ,  G01N2333/71 ,  Y10S436/813 ,  Y10S436/817

摘要： It has been determined that nerve growth factor binds to a cell surface protein of human neural crest origin having a molecular weight of about 75,000 daltons. New monoclonal antibodies specifically imunoprecipitate these receptor molecules, and also inhibit binding of the hormone to the receptor. These monoclonal antibodies show significantly higher reactivity with primary and metastatic melanoma cell lines than with melanocytes. The antibodies are used as the basis of a method of diagnosing neural crest disease.

公开(公告)号：EP4412652A1

公开(公告)日：2024-08-14

申请号：EP22879484.8

申请日：2022-10-06

申请人： The Wistar Institute of Anatomy and Biology

发明人： WEINER, David ,  BORDOLOI, Devivasha

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/30

CPC分类号： A61P35/00 ,  C07K2317/3120130101 ,  C07K2317/62220130101 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/2866 ,  C07K16/2803 ,  C07K16/2869 ,  C07K16/1063 ,  C07K16/2827 ,  C07K2317/7320130101

公开(公告)号：EP4003421A1

公开(公告)日：2022-06-01

申请号：EP20847903.0

申请日：2020-07-31

申请人： The Wistar Institute of Anatomy and Biology

发明人： WEINER, David ,  PATEL, Ami ,  PARZYCH, Elizabeth

IPC分类号： A61K39/40 ,  C07K16/12

公开(公告)号：EP3833443A1

公开(公告)日：2021-06-16

申请号：EP19762508.0

申请日：2019-08-09

申请人： Compass Therapeutics LLC ,  The Wistar Institute Of Anatomy And Biology ,  Moffitt Cancer Center ,  Conejo-Garcia, Jose, R. ,  Payne, Kyle, Kristopher

发明人： SCHMIDT, Michael, March ,  MCLAUGHLIN, Brooke, T. ,  BOBROWICZ, Piotr ,  CONEJO-GARCIA, Jose, R. ,  PAYNE, Kyle, Kristopher

IPC分类号： A61P35/00 ,  C07K16/28 ,  A61K39/00

公开(公告)号：EP3703762A1

公开(公告)日：2020-09-09

申请号：EP18872286.2

申请日：2018-11-02

申请人： The Wistar Institute Of Anatomy And Biology ,  University of Iowa Research Foundation

发明人： PUCHALT, Alfredo Perales ,  LUECK, John ,  AHERN, Christopher A. ,  WEINER, David B.

IPC分类号： A61K48/00 ,  C12N15/00 ,  C07H21/04

公开(公告)号：EP3691694A1

公开(公告)日：2020-08-12

申请号：EP18864252.4

申请日：2018-10-03

申请人： The Wistar Institute Of Anatomy And Biology

发明人： WEINER, David ,  DUPERRET, Elizabeth

IPC分类号： A61K48/00 ,  A61K39/395 ,  C07K16/28