公开(公告)号：EP1868634A2

公开(公告)日：2007-12-26

申请号：EP06748307.3

申请日：2006-03-07

申请人： UNIVERSITY OF ROCHESTER

发明人： SMRCKA, Alan, V. ,  FONT, Jose ,  BONACCI, Tabetha

IPC分类号： A61K38/17

CPC分类号： A61K31/352 ,  G01N33/6872 ,  G01N2333/4719 ,  G01N2500/00

摘要： The present invention relates to methods for identifying agents which bind to specific amino acid residues of the protein interaction site of G protein β subunit. Compounds identified in accordance with the assay of the invention and methods for using the compound for modulating at least one activity of a G protein are also provided.

公开(公告)号：EP1845969A2

公开(公告)日：2007-10-24

申请号：EP06733772.5

申请日：2006-01-19

申请人： University of Rochester

发明人： PERRY, Seth, W. ,  NORMAN, John, Phillip ,  DEWHURST, Stephen ,  GELBARD, Harris, A.

IPC分类号： A61K31/203

CPC分类号： A61K31/203 ,  A61K31/277 ,  A61K31/64 ,  A61K45/06 ,  A61K2300/00

摘要： Provided is a method of protecting a neuron from dysfunction induced by an HIV neurotoxin comprising contacting the cell with a therapeutically effective dose of an inhibitor of mitochondrial hyperpolarization.

公开(公告)号：EP1817039A2

公开(公告)日：2007-08-15

申请号：EP05851577.6

申请日：2005-11-14

申请人： UNIVERSITY OF ROCHESTER

发明人： TIAN, Guo, Feng ,  NEDERGAARD, Maiken

IPC分类号： A61K31/553

CPC分类号： A61K31/553

摘要： The present invention is directed to a method of treating or preventing epileptic seizures in a subject and a method of inhibiting hypersynchronous burst activity of neurons by administering an agent which interferes with glutamate, aspartate, and/or ATP release from astrocytes. Also presented is a method of identifying agents suitable for treating or preventing epileptic seizures.

公开(公告)号：EP1773371A2

公开(公告)日：2007-04-18

申请号：EP05802434.0

申请日：2005-07-25

申请人： THE UNIVERSITY OF ROCHESTER

发明人： ZLOKOVIC, Berislav, V. ,  LIU, Dong ,  CHENG, Tong ,  GUO, Huang

IPC分类号： A61K38/16 ,  C12Q1/00

CPC分类号： A61K38/4866 ,  A61K38/49 ,  A61K2300/00

摘要： Activated protein C (APC), a prodrug, and/or a variant of APC may be used to inhibit undesirable effects of plasminogen activator: e.g., apoptosis or cell death of neurons and endothelial cells, brain hemorrhage or intracerebral bleeding, and/or tissue damage in a subject’s brain. Inhibition appears to act through the extrinsic pathway of death receptor signal transduction. This represents an improvement in treatment using plasminogen activator (e.g., fibrinolysis). By reducing undesirable effects, the window for fibrinolythic therapy by plasminogen activator may be widened.

公开(公告)号：EP1753506A1

公开(公告)日：2007-02-21

申请号：EP05746916.5

申请日：2005-05-04

申请人： UNIVERSITY OF ROCHESTER

发明人： ROSERO, Spencer

IPC分类号： A61N1/39

CPC分类号： A61N1/05 ,  A61N1/372 ,  A61N1/37288 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/3956

摘要： A leadless implantable cardioverter defibrillator (5) for treatment of sudden cardiac death includes a controller and at least one remote module. The defibrillator does not require transvenous/vascular access for intracardiac lead placement. The controller is leadless and uses subcutaneous tissue in proximity of the chest and abdomen for both sensing and defibrillation. The controller and one or more remote sensors sense a need for defibrillation and wireless communicate with the controller. The controller and one of the sensors discharge a synchronized defibrillation pulse to the surrounding subcutaneous tissue in proximity to the heart.

摘要翻译： 用于治疗心脏性猝死的无引线植入式心脏复律除颤器（5）包括控制器和至少一个远程模块。 除颤器不需要经静脉/血管通路进行心内导联置入。 控制器无引线，并使用胸部和腹部附近的皮下组织进行感应和除颤。 控制器和一个或多个远程传感器感测除颤需求并与控制器进行无线通信。 控制器和其中一个传感器向心脏附近的周围皮下组织释放同步除颤脉冲。

公开(公告)号：EP1747043A2

公开(公告)日：2007-01-31

申请号：EP05745286.4

申请日：2005-05-04

申请人： UNIVERSITY OF ROCHESTER

发明人： ROSERO, Spencer

IPC分类号： A61N1/375

CPC分类号： A61N1/05 ,  A61N1/362 ,  A61N1/372 ,  A61N1/37205 ,  A61N1/37288 ,  A61N1/375 ,  A61N1/3756

摘要： An implantable device for monitoring physiological changes in an organism is disclosed. The device includes a matrix positioned proximate a biological material of the organism, an irradiation device associated with the matrix for exposing the biological material to radiation, and a sensor device associated with the matrix for detecting a response of the biological material to the irradiation. The response can be used to remotely detect a characteristic of the biological material.

公开(公告)号：EP1340088B1

公开(公告)日：2007-01-17

申请号：EP01274137.7

申请日：2001-11-14

申请人： UNIVERSITY OF ROCHESTER

发明人： ZAUDERER, Maurice ,  SMITH, Ernest, S.

IPC分类号： G01N33/68

CPC分类号： C07K16/00 ,  C07K2317/21 ,  C07K2317/22 ,  C07K2317/55 ,  C07K2317/622 ,  C12N2799/023

摘要： The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a method of producing immunoglobulin heavy and light chain libraries, particularly using the trimolecular recombination method, for expression in eukaryotic cells. The invention further provides methods of selecting and screening for antigen-specific immunoglobulin molecules, and antigen-specific fragments thereof. The invention also provides kits for producing, screening and selecting antigen-specific immunoglobulin molecules. Finally, the invention provides immunoglobulin molecules, and antigen-specific fragments thereof, produced by the methods provided herein.

公开(公告)号：EP1718771A2

公开(公告)日：2006-11-08

申请号：EP05769068.7

申请日：2005-01-03

申请人： UNIVERSITY OF ROCHESTER

发明人： MILLER, Benjamin L. ,  STROHSAHL, Christopher M.

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07H21/02

CPC分类号： B82Y10/00 ,  B82Y5/00 ,  C12Q1/6813 ,  C12Q1/6818 ,  C12Q1/6851 ,  C12Q2525/301 ,  C12Q2561/113 ,  C12Q2565/1015

摘要： Method of identifying molecular beacons in which a secondary structure prediction algorithm is employed to identify oligonucleotide sequences within a target gene having the requisite hairpin structure. Isolated oligonucleotides, molecular beacons prepared from those oligonucleotides, and their use are also disclosed.

公开(公告)号：EP1718659A1

公开(公告)日：2006-11-08

申请号：EP05723138.3

申请日：2005-02-16

申请人： UNIVERSITY OF ROCHESTER

发明人： KYRKANIDES, Stephanos

IPC分类号： C07H19/00 ,  C07H21/00 ,  A01N43/04 ,  A61K31/70 ,  C12N5/00 ,  C12N5/02 ,  C12N15/02

CPC分类号： C12N15/86 ,  A01K67/0276 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2217/20 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/0306 ,  A61K35/30 ,  A61K35/33 ,  A61K38/47 ,  A61K48/00 ,  C12N15/8509 ,  C12N2740/15043 ,  C12N2800/30 ,  C12N2830/008 ,  C12N2830/85 ,  C12N2840/203 ,  C12N2840/206

摘要： Disclosed are compositions and methods related to delivering a nucleic acid to the central nervous system.

公开(公告)号：EP1699469A2

公开(公告)日：2006-09-13

申请号：EP04812686.6

申请日：2004-12-02

申请人： UNIVERSITY OF ROCHESTER

发明人： FAY, Philip, J. ,  WAKABAYASHI, Hironao

IPC分类号： A61K35/14 ,  A61K35/16 ,  A61K38/00 ,  C07K1/00 ,  C07K14/00 ,  C12N15/63 ,  C12N15/85

CPC分类号： C07K14/755 ,  A61K38/00

摘要： The present invention relates to recombinant factor VIII having a specific activity that is higher than that of the corresponding wild-type factor VIII. The present invention also relates to methods of making and using the recombinant factor VIII. The present invention also relates to an isolated nucleic acid molecule that encodes the recombinant factor VIII, as well as DNA expression systems and host cells containing the isolated nucleic acid molecule.