公开(公告)号：EP1868634A2

公开(公告)日：2007-12-26

申请号：EP06748307.3

申请日：2006-03-07

申请人： UNIVERSITY OF ROCHESTER

发明人： SMRCKA, Alan, V. ,  FONT, Jose ,  BONACCI, Tabetha

IPC分类号： A61K38/17

CPC分类号： A61K31/352 ,  G01N33/6872 ,  G01N2333/4719 ,  G01N2500/00

摘要： The present invention relates to methods for identifying agents which bind to specific amino acid residues of the protein interaction site of G protein β subunit. Compounds identified in accordance with the assay of the invention and methods for using the compound for modulating at least one activity of a G protein are also provided.

公开(公告)号：EP2147310A2

公开(公告)日：2010-01-27

申请号：EP08827151.5

申请日：2008-04-28

申请人： University of Rochester

发明人： SMRCKA, Alan, V. ,  BLAXALL, Burns, C. ,  BIDLACK, Jean, M.

IPC分类号： G01N33/53

CPC分类号： G01N33/74 ,  A61K31/122 ,  A61K31/4709 ,  A61K31/498 ,  G01N33/564 ,  G01N33/6893 ,  G01N33/9486 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2800/32 ,  G01N2800/325 ,  Y02A50/393 ,  Y02A50/397

摘要： Disclosed are compositions and methods for treating diseases associated with G protein &bgr;γ subunit activity.

摘要翻译： 鉴定与G蛋白β亚基的蛋白质相互作用位点的至少一个氨基酸残基结合的试剂的方法在存在结合至少一个氨基酸的肽的存在下使G蛋白β亚基与测试试剂接触 β亚基的蛋白质相互作用位点的残基，并确定该试剂是否抑制该肽的结合。