公开(公告)号：EP2820419A1

公开(公告)日：2015-01-07

申请号：EP13755187.5

申请日：2013-02-27

申请人： Astute Medical, Inc.

发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

IPC分类号： G01N33/50

CPC分类号： G01N33/6893 ,  G01N33/54306 ,  G01N2333/4706 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect Chitinase-3-like protein 1 as a predictive biomarker in renal injuries.

摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 特别地，本发明涉及使用配置成检测几丁质酶-3样蛋白1作为肾损伤中预测性生物标志物的一种或多种测定。

公开(公告)号：EP2748605A1

公开(公告)日：2014-07-02

申请号：EP12832845.7

申请日：2012-08-24

申请人： Astute Medical, Inc.

发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

IPC分类号： G01N33/53

CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/60

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Heat shock 70 kDa protein 1, Alpha-1-antitrypsin Neutrophil elastase complex, Stromelysin-1:Metalloproteinase inhibitor 2 complex, 72 kDa type IV collagenase:Metalloproteinase inhibitor 2 complex, Insulin-like growth factor 1 receptor, Myeloid differentiation primary response protein MyD88, Neuronal cell adhesion molecule, and Tumor necrosis factor ligand superfamily member 10 as diagnostic and prognostic biomarkers in renal injuries.

摘要翻译： 本发明涉及一种用于在患有或疑似患有肾损伤的受试者监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用被配置为检测选自热休克70kDa的蛋白1，α-1抗胰蛋白酶嗜中性弹性蛋白酶复合物，溶基质蛋白酶-1金属蛋白酶抑制剂2复合物中选择的肾损伤标记物的一个或多个测定 ，72kDa的Ⅳ型胶原酶：金属蛋白酶抑制剂2络合物，胰岛素样生长因子1种受体，髓样分化初级应答蛋白MyD88的，神经细胞粘附分子，和肿瘤坏死因子配体超家族成员在肾损伤10级的诊断和预后的生物标志物。

公开(公告)号：EP2531620A1

公开(公告)日：2012-12-12

申请号：EP11740468.1

申请日：2011-02-04

申请人： Astute Medical, Inc.

发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

IPC分类号： C12Q1/68 ,  G01N33/567

CPC分类号： G01N33/6893 ,  G01N33/6863 ,  G01N33/86 ,  G01N2333/4745 ,  G01N2333/522 ,  G01N2333/96447 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Coagulation factor VII, CA 19-9, Insulin-like growth factor-binding protein 7, C-X-C motif chemokine 6, and C-C motif chemokine 13 as diagnostic and prognostic biomarkers in renal injuries.

摘要翻译： 本发明涉及用于监测，诊断，预后和确定患有或怀疑患有肾损伤的受试者的治疗方案的方法和组合物。 具体而言，本发明涉及使用一种或多种配置为检测选自凝血因子VII，CA 19-9，胰岛素样生长因子结合蛋白7，CXC基序趋化因子6， 和CC基序趋化因子13作为肾损伤中的诊断和预后生物标志物。

公开(公告)号：EP2470905A1

公开(公告)日：2012-07-04

申请号：EP10812639.2

申请日：2010-08-27

申请人： Astute Medical, Inc.

发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin ,  KAMPF, James, Patrick

IPC分类号： G01N33/53

CPC分类号： G01N33/92 ,  G01N33/6893 ,  G01N2333/775 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/60

摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more biomarkers selected from the group consisting of Tumor necrosis factor receptor superfamily member 10B, Cadherin-16, Caspase-9, Bcl2 antagonist of cell death, Caspase-1, Cadherin-1, Poly [ADP-ribose] polymerase 1, Cyclin-dependent kinase inhibitor 1, Cadherin-5, Myoglobin, Apolipoprotein A-II, Mucin-16, Carcinoembryonic antigen-related cell adhesion molecule 5, and Cellular tumor antigen p53 as diagnostic and prognostic biomarker assays in renal injuries.

公开(公告)号：EP2393937A1

公开(公告)日：2011-12-14

申请号：EP10739150.0

申请日：2010-02-05

申请人： Astute Medical, Inc.

发明人： ANDERBERG, Joseph ,  GRAY, Jeff ,  MCPHERSON, Paul ,  NAKAMURA, Kevin

IPC分类号： C12Q1/42

CPC分类号： G01N33/6893 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60

摘要： Disclosed are methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury In particular, disclosed are assays that detect one or more markers selected from the group consisting of Prostatic acid phosphatase, Lactotransfenin, Soluble erythropoietin receptor, Von Willebrand factor, Soluble endothelial protein C receptor, and Beta-2-glycoproteιn 1 as diagnostic and prognostic biomarkers in renal injuries.

摘要翻译： 公开了用于在患有或怀疑患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。具体而言，公开了检测一种或多种选自前列腺酸性磷酸酶， 乳酸转氨酶，可溶性促红细胞生成素受体，冯维勒布兰德因子，可溶性内皮蛋白C受体和β-2-糖蛋白1作为肾损伤中的诊断和预后生物标志物。