-
71.发明公开4-(ORTHO)-FLUOROPHENYL-5-FLUOROPYRIMIDIN-2-YL AMINES CONTAINING A SULFOXIMINE GROUP 有权4-（邻位）WITH A亚磺酰亚胺氟苯基-5-氟嘧啶-2-基 - 胺
公开(公告)号：EP2920153A1
公开(公告)日：2015-09-23
申请号：EP13794840.2
申请日：2013-11-11
发明人： LÜCKING, Ulrich , KOSEMUND, Dirk , BOHLMANN, Rolf , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf
IPC分类号： C07D239/42 , A61K31/505 , A61P9/00 , A61P35/00
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D405/04
摘要： The present invention relates to 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
-
72.发明公开
公开(公告)号：EP2791143A1
公开(公告)日：2014-10-22
申请号：EP12809680.7
申请日：2012-12-11
发明人： COLLIN, Marie-Pierre , BROHM, Dirk , HÉROULT, Mélanie , LOBELL, Mario , HÜBSCH, Walter , LUSTIG, Klemens , GRÜNEWALD, Sylvia , BÖMER, Ulf , VÖHRINGER, Verena , LINDNER, Niels
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553 , C07D409/04 , C07D409/14
摘要： This invention relates to novel substituted 5-(l-benzothiophen-2-yl)pyrrolo[2,l-fJ[l,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
-
公开(公告)号：EP2638044A1
公开(公告)日：2013-09-18
申请号：EP11784977.8
申请日：2011-11-08
IPC分类号： C07D487/04
CPC分类号： A61K31/541 , A61K31/519 , A61K31/5377 , A61K39/39558 , C07D487/04
摘要： The present invention relates to alkoxy-substituted 2,3-dihydroimidazo[1,2-c]quinazoline compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及通式（I）的烷氧基取代的2,3-二氢咪唑并[1,2-c]喹唑啉化合物，其中R1，R2和R3如权利要求中所定义，涉及制备所述化合物的方法， 用于制备所述化合物的中间体，包含所述化合物的药物组合物和组合以及所述化合物用于制备用于治疗或预防疾病，特别是高增殖和/或血管生成障碍的药物组合物的用途， 作为唯一的药剂或与其它活性成分组合。
-
公开(公告)号：EP2424537A1
公开(公告)日：2012-03-07
申请号：EP10721661.6
申请日：2010-04-24
发明人： KOPPITZ, Marcus , BADER, Benjamin , BÖMER, Ulf , KREFT, Bertolt , LIENAU, Philip , MARQUARDT, Tobias , PRECHTL, Stefan , SIEMEISTER, Gerhard , WEGSCHEID-GERLACH, Christof
IPC分类号： A61K31/4985 , C07D487/02 , A61P35/00 , A61P37/00 , A61P29/00
CPC分类号： C07D487/02
摘要： The present invention relates to substituted imidazoquinoxaline compounds of general formula (I) as inhibitors of Mps-1 Kinase or TTK, and being active against inflammation and cancer.
摘要翻译： 本发明涉及通式（I）的取代的咪唑并喹喔啉化合物作为Mps-1激酶或TTK的抑制剂，并且对炎症和癌症具有活性。
-
公开(公告)号：EP2376463A1
公开(公告)日：2011-10-19
申请号：EP09767957.5
申请日：2009-11-28
发明人： HASSFELD, Jorma , RÖHN, Ulrike , FRIEBE, Matthias , LEHMANN, Lutz , HEINRICH, Tobias , KRAUSE, Sabine , BROCKSCHNIEDER, Damian , DYRKS,Thomas , THIELE, Andrea , BÖMER, Ulf , MÖNNING, Ursula , BERGER, Markus , SIEGEL, Stephan
IPC分类号： C07D277/82 , C07D417/12 , A61K31/428 , A61P25/28
CPC分类号： C07D277/82 , C07D417/12
摘要： This invention relates to compounds of formula I (benzothiazoles) suitable for labelling or already labelled by
18 F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.
-
-
-
-
搜索结果
75 条记录 (耗时 0.03 秒)
