公开(公告)号：EP3308798A2

公开(公告)日：2018-04-18

申请号：EP17203789.7

申请日：2013-06-06

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： YUAN, Quan ,  ZHANG, Tianying ,  LUO, Wenxin ,  CHEN, Yixin ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： A61K39/12

摘要： The present invention relates to epitope peptides (or mutants thereof) for treating hepatitis B virus infection, recombinant proteins comprising such epitope peptides (or mutants thereof) and carrier proteins, and uses of such epitope peptides (or mutants thereof) and recombinant proteins. The present invention also relates to antibodies against such epitope peptides, cell lines producing said antibodies, and uses thereof. Furthermore, the present invention relates to vaccines or pharmaceutical compositons for treating or alleviating one or more symptoms associated with hepatitis B virus infection, which comprise the recombinant proteins or antibodies according to the invention, respectively.

摘要翻译： 本发明涉及用于治疗乙型肝炎病毒感染的表位肽（或其突变体），包含此类表位肽（或其突变体）和载体蛋白的重组蛋白，以及此类表位肽（或其突变体）和重组蛋白的用途。 本发明还涉及抗此类表位肽的抗体，产生所述抗体的细胞系及其用途。 此外，本发明涉及用于治疗或缓解与乙型肝炎病毒感染相关的一种或多种症状的疫苗或药物组合物，其分别包含根据本发明的重组蛋白或抗体。

公开(公告)号：EP2899267A1

公开(公告)日：2015-07-29

申请号：EP13838213.0

申请日：2013-06-24

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： GE, Shengxiang ,  LI, Tingdong ,  GUO, Qingshun ,  XU, Feihai ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C12N7/04 ,  C12P21/02 ,  C07K1/16 ,  C07K1/14 ,  C12R1/19

CPC分类号： C12N7/00 ,  A61K38/162 ,  A61K39/00 ,  C12N7/04 ,  C12N2720/12322 ,  C12N2720/12323 ,  C12N2720/12333 ,  C12N2720/12334 ,  C12N2720/12352

摘要： The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.

摘要翻译： 本发明涉及体外制备轮状病毒双层病毒样颗粒的方法。 该方法包括以下步骤：从裂解上清液中纯化轮状病毒VP6蛋白，以及体外组装由VP2蛋白和VP6蛋白组成的双层病毒样颗粒，其中蛋白质和病毒样颗粒可用于预防或 减少轮状病毒感染引起的临床症状。

公开(公告)号：EP2716661A1

公开(公告)日：2014-04-09

申请号：EP12793630.0

申请日：2012-06-01

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： LI, Shaowei ,  SONG, Cuiling ,  YANG, Chunyan ,  GU, Ying ,  LUO, Wenxin ,  XIA, Ningshao

IPC分类号： C07K19/00 ,  A61K38/16 ,  A61K47/48 ,  A61P31/14 ,  A61P1/16 ,  A61P31/16 ,  C12N15/62

CPC分类号： A61K39/39 ,  A61K38/00 ,  A61K39/05 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/6037 ,  C07K14/005 ,  C07K14/34 ,  C07K2319/03 ,  C07K2319/55 ,  C07K2319/74 ,  C12N7/00 ,  C12N9/1048 ,  C12N15/62 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/28122 ,  C12N2770/28134

摘要： Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid.

公开(公告)号：EP2594579A1

公开(公告)日：2013-05-22

申请号：EP11806304.9

申请日：2011-07-15

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： LI, Shaowei ,  WEI, Minxi ,  KONG, Xianglin ,  WANG, Yingbin ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C07K14/025 ,  C12N15/37 ,  A61K39/12 ,  A61K38/16 ,  A61P31/12 ,  A61P15/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/585 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20023 ,  C12N2710/20034

摘要： Provided are an N-terminal truncated L1 protein of the Human Papillomavirus Type 58, a coding sequence and preparation method thereof, and a virus-like particle comprising the protein. Uses of the protein and the virus-like particle in the preparation of a pharmaceutical composition or a vaccine are further provided. The pharmaceutical composition or vaccine is used for prevention of HPV infection and a disease caused by HPV infection.

摘要翻译： 提供人类乳头瘤病毒58型的N-末端截短的L1蛋白，其编码序列及其制备方法和包含该蛋白质的病毒样颗粒。 还提供了蛋白质和病毒样颗粒在制备药物组合物或疫苗中的用途。 药物组合物或疫苗用于预防HPV感染和HPV感染引起的疾病。

公开(公告)号：EP2460878A1

公开(公告)日：2012-06-06

申请号：EP10803804.3

申请日：2010-07-27

申请人： New Jersey Medical School ,  Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： ZHU, Hua ,  LI, Yimin ,  XIA, Ningshao ,  CHENG, Tong ,  YE, Xiangzhong

IPC分类号： C12N7/00 ,  C12N7/04 ,  C12N7/01 ,  A61K39/25 ,  A61P31/22 ,  C12N15/63 ,  C12N5/10

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/25 ,  A61K2039/5254 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/16722 ,  C12N2710/16734

摘要： Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

摘要翻译： 提供了一种ORF7缺陷型水痘病毒，包含病毒的疫苗及其用途，以及用于生产病毒的方法。