-
1.发明授权FUSION PROTEIN COMPRISING DIPHTHERIA TOXIN NON-TOXIC MUTANT CRM197 OR FRAGMENT THEREOF 有权含有DIPHTHERIA毒素非毒性突变体CRM197或其片段的融合蛋白
公开(公告)号：EP2716661B1
公开(公告)日：2018-03-07
申请号：EP12793630.0
申请日：2012-06-01
发明人： LI, Shaowei , SONG, Cuiling , YANG, Chunyan , GU, Ying , LUO, Wenxin , XIA, Ningshao
CPC分类号： A61K39/39 , A61K38/00 , A61K39/05 , A61K39/12 , A61K39/29 , A61K2039/55505 , A61K2039/55516 , A61K2039/55544 , A61K2039/6037 , C07K14/005 , C07K14/34 , C07K2319/03 , C07K2319/55 , C07K2319/74 , C12N7/00 , C12N9/1048 , C12N15/62 , C12N2760/16122 , C12N2760/16134 , C12N2770/28122 , C12N2770/28134
摘要： Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid.
-
2.发明公开FUSION PROTEIN COMPRISING DIPHTHERIA TOXIN NON-TOXIC MUTANT CRM197 OR FRAGMENT THEREOF 有权使用无毒的白喉毒素突变体CRM197或其片段融合蛋白
公开(公告)号：EP2716661A1
公开(公告)日：2014-04-09
申请号：EP12793630.0
申请日：2012-06-01
发明人： LI, Shaowei , SONG, Cuiling , YANG, Chunyan , GU, Ying , LUO, Wenxin , XIA, Ningshao
CPC分类号： A61K39/39 , A61K38/00 , A61K39/05 , A61K39/12 , A61K39/29 , A61K2039/55505 , A61K2039/55516 , A61K2039/55544 , A61K2039/6037 , C07K14/005 , C07K14/34 , C07K2319/03 , C07K2319/55 , C07K2319/74 , C12N7/00 , C12N9/1048 , C12N15/62 , C12N2760/16122 , C12N2760/16134 , C12N2770/28122 , C12N2770/28134
摘要： Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid.
-
搜索结果
2 条记录 (耗时 0.011 秒)
