公开(公告)号：EP4245767A1

公开(公告)日：2023-09-20

申请号：EP21891223.6

申请日：2021-11-12

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： GU, Ying ,  DENG, Tingting ,  ZHANG, Hui ,  HUANG, Fang ,  CHEN, Gege ,  LIN, Yanling ,  LI, Shaowei ,  XIA, Ningshao

IPC分类号： C07K14/005 ,  C07K16/10 ,  A61K39/12 ,  A61K39/21

摘要： Provided are a newly designed HIV-1 Env trimer protein, and an HIV-1 pseudovirus and virus expressing the Env trimer protein, and the use thereof for the prevention and/or treatment of HIV infection.

公开(公告)号：EP3812395A1

公开(公告)日：2021-04-28

申请号：EP19815298.5

申请日：2019-06-04

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： LI, Shaowei ,  SONG, Shuo ,  HE, Maozhou ,  SHI, Jingjie ,  GU, Ying ,  XIA, Ningshao

IPC分类号： C07K14/025 ,  C12N15/11 ,  A61K39/12 ,  A61P35/00

摘要： The present invention relates to a mutated HPV18 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (for example, HPV18 and HPV45, or HPV18, HPV45 and HPV59), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

公开(公告)号：EP3858867A1

公开(公告)日：2021-08-04

申请号：EP19867338.6

申请日：2019-09-26

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： LI, Shaowei ,  WANG, Daning ,  CHEN, Jie ,  GU, Ying ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C07K19/00 ,  C12N15/62 ,  C12N15/63 ,  A61K39/295 ,  A61P31/20

摘要： Provided are a mutated HPV51 L1 protein or a variant thereof, a coding sequence thereof, a preparation method therefor, and a virus-like particle containing same, wherein the protein or the variant and the virus-like particle thereof are capable of inducing neutralizing antibodies against at least two types of HPV (for example, HPV51 and HPV69, or HPV51, HPV69 and HPV26). Also provided is the use of the above-mentioned protein and the virus-like particle for preparing a pharmaceutical composition or a vaccine, wherein the pharmaceutical composition or the vaccine can be used to prevent infections of the at least two types of HPV and diseases caused by the infections, such as cervical cancer and condyloma acuminatum.

公开(公告)号：EP3385273A1

公开(公告)日：2018-10-10

申请号：EP16870020.1

申请日：2016-12-02

申请人： Xiamen University ,  Xiamen Innovax Biotech Co. , Ltd.

发明人： LI, Shaowei ,  LI, Zhihai ,  SONG, Shuo ,  HE, Maozhou ,  GU, Ying ,  XIA, Ningshao

IPC分类号： C07K14/025 ,  C12N15/37 ,  C12N7/04 ,  A61K39/12 ,  A61P31/20 ,  A61P35/00 ,  A61P17/12

CPC分类号： A61K39/12 ,  C07K14/025 ,  C12N7/04

摘要： Provided are a mutated HPV58 L1 protein or a variant thereof, a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein or a variant thereof and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types, and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

公开(公告)号：EP2716661B1

公开(公告)日：2018-03-07

申请号：EP12793630.0

申请日：2012-06-01

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： LI, Shaowei ,  SONG, Cuiling ,  YANG, Chunyan ,  GU, Ying ,  LUO, Wenxin ,  XIA, Ningshao

IPC分类号： C07K19/00 ,  A61K38/16 ,  A61P31/14 ,  A61P1/16 ,  A61P31/16 ,  C12N15/62

CPC分类号： A61K39/39 ,  A61K38/00 ,  A61K39/05 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/6037 ,  C07K14/005 ,  C07K14/34 ,  C07K2319/03 ,  C07K2319/55 ,  C07K2319/74 ,  C12N7/00 ,  C12N9/1048 ,  C12N15/62 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/28122 ,  C12N2770/28134

摘要： Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid.

公开(公告)号：EP2716661A1

公开(公告)日：2014-04-09

申请号：EP12793630.0

申请日：2012-06-01

申请人： Xiamen University ,  Xiamen Innovax Biotech Co., Ltd.

发明人： LI, Shaowei ,  SONG, Cuiling ,  YANG, Chunyan ,  GU, Ying ,  LUO, Wenxin ,  XIA, Ningshao

IPC分类号： C07K19/00 ,  A61K38/16 ,  A61K47/48 ,  A61P31/14 ,  A61P1/16 ,  A61P31/16 ,  C12N15/62

CPC分类号： A61K39/39 ,  A61K38/00 ,  A61K39/05 ,  A61K39/12 ,  A61K39/29 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/6037 ,  C07K14/005 ,  C07K14/34 ,  C07K2319/03 ,  C07K2319/55 ,  C07K2319/74 ,  C12N7/00 ,  C12N9/1048 ,  C12N15/62 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2770/28122 ,  C12N2770/28134

摘要： Provided in the present invention are a diphtheria toxin non-toxic mutant CRM197 or a fragment thereof as an adjuvant in a fusion protein and the use thereof to enhance the immunogenicity of a target protein fused therewith, for example, an HEV capsid protein, or an influenza virus M2 protein or an immunogenic fragment thereof. Also provided is a method for enhancing the immunogenicity of a target protein, comprising the fusion expression of the CRM197 or the fragment thereof with the target protein to form a fusion protein. Further provided is a fusion protein comprising the CRM197 or the fragment thereof and a target protein, the CRM197 or the fragment thereof enhancing the immunogenicity of the target protein. The present invention also provides an isolated nucleic acid encoding the fusion protein, a construct and a vector comprising said nucleic acid, and a host cell comprising the nucleic acid.

公开(公告)号：EP2154147A1

公开(公告)日：2010-02-17

申请号：EP08748431.7

申请日：2008-04-29

申请人： Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： GU, Ying ,  LI, Shaowei ,  WEI, Minxi ,  XIAN, Yangling ,  LUO, Wenxin ,  XIA, Ningshao

IPC分类号： C07K14/025 ,  C12N15/37 ,  C12N7/02 ,  C07K1/18 ,  A61K39/12 ,  A61P31/20 ,  A61P15/02 ,  A61P35/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034

摘要： The invention relates to a truncated L1 protein of the Human Papillomavirus Type 16, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of cervical caner.

摘要翻译： 本发明涉及16型人乳头瘤病毒的截短L1蛋白，由蛋白质构成的病毒样颗粒，包含所述病毒样颗粒的疫苗，以及该疫苗在预防宫颈癌中的用途。

公开(公告)号：EP2154147B1

公开(公告)日：2015-10-07

申请号：EP08748431.7

申请日：2008-04-29

申请人： Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： GU, Ying ,  LI, Shaowei ,  WEI, Minxi ,  XIAN, Yangling ,  LUO, Wenxin ,  XIA, Ningshao

IPC分类号： C12N7/02 ,  C07K14/025 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034

公开(公告)号：EP2154148B1

公开(公告)日：2016-06-22

申请号：EP08757380.4

申请日：2008-05-29

申请人： Xiamen University ,  Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.

发明人： ZHANG, Jun ,  WANG, Jin ,  YANG, Chunyan ,  GU, Ying ,  LI, Shaowei ,  XIA, Ningshao

IPC分类号： C07K14/025 ,  C12N15/37 ,  C12N15/63 ,  C12N7/02 ,  C07K1/18 ,  A61K39/295 ,  A61K39/12 ,  A61P31/20 ,  A61P15/00 ,  A61P17/12

CPC分类号： A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20023 ,  C12N2710/20034

公开(公告)号：EP2154148A1

公开(公告)日：2010-02-17

申请号：EP08757380.4

申请日：2008-05-29

申请人： Xiamen University ,  Beijing Wantai Biological Pharmacy Enterprise Co., Ltd.

发明人： ZHANG, Jun ,  WANG, Jin ,  YANG, Chunyan ,  GU, Ying ,  LI, Shaowei ,  XIA, Ningshao

IPC分类号： C07K14/025 ,  C12N15/37 ,  C12N15/63 ,  C12N7/02 ,  C07K1/18 ,  A61K39/295 ,  A61K39/12 ,  A61P31/20 ,  A61P15/00 ,  A61P17/12

CPC分类号： A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20023 ,  C12N2710/20034

摘要： The invention relates to a truncated L1 protein of the Human Papillomavirus Type 11, a virus-like particle consisting of the protein, a vaccine comprising said virus-like particle, and the use of the vaccine in the prevention of condyloma acuminatum or HPV infections.

摘要翻译： 本发明涉及11型人乳头瘤病毒的截短的L1蛋白，由蛋白质组成的病毒样颗粒，包含所述病毒样颗粒的疫苗，以及该疫苗在预防尖锐湿疣或HPV感染中的用途。