利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

705 条记录 (耗时 0.022 秒)

    NEUE 7-ALPHA,17-ALPHA-BIS-ALKYLIERTE TESTOSTERONDERIVATE UND IHRE VERWENDING ZUR LANGZEITTHERAPIE VON ANDROGEN-ABHÄNGIGEN ERKRANKUNGEN
    71.
    发明公开
    NEUE 7-ALPHA,17-ALPHA-BIS-ALKYLIERTE TESTOSTERONDERIVATE UND IHRE VERWENDING ZUR LANGZEITTHERAPIE VON ANDROGEN-ABHÄNGIGEN ERKRANKUNGEN 有权
    NEW 7-α，17-α-二TO-烷基化睾酮衍生物及其VERWENDING长期治疗雄激素依赖性疾病

    公开(公告)号：EP1140972A1

    公开(公告)日：2001-10-10

    申请号：EP99967003.7

    申请日：1999-12-23

    申请人： Schering Aktiengesellschaft

    发明人： CLEVE, Arwed ,  SAUER, Gerhard ,  HUWE, Christoph ,  PARCZYK, Karsten ,  HOFFMANN, Jens ,  SCHNEIDER, Martin

    IPC分类号： C07J1/00 ,  A61K31/565 ,  C07J31/00 ,  C07J41/00 ,  C07J43/00 ,  C07J33/00 ,  C07J51/00

    CPC分类号： C07J51/00 ,  C07J1/0033 ,  C07J1/0037 ,  C07J31/006 ,  C07J33/002 ,  C07J41/0038 ,  C07J41/0094 ,  C07J43/003

    摘要： The invention relates to new 7α, 17α, 17β-substituted testosterone derivatives of general formula (I) and their use as pure antiandrogens for the long-term therapy of androgen-dependent diseases, notably for the long-term antiandrogen therapy of prostate carcinoma. In the general formula (I) A is an unbranched C6-C13-alkylene group; B is an oxygen atom, -S(O)p- group, in which p is 0, 1 or 2, an iminocarbonyl group -C(O)N(Y)-, an imino group -N(Y)-, a carbonylimino group -N(Y)C(O)-, a sulfonylimino group -NN(Y)S(O)2-, where Y is a hydrogen atom or a C1-C8-alkyl group, a sulfonyloxy group -OS(O)2-, a dimethylsilyloxy group -O--Si(CH3)2- or a carbonylsulfanyl group -SC(O)- or a bond between A and C or, together with C, a bond between A and D; C is a bond between B and D or, together with B, a bond between A and D or an unbranched C1-C6-alkylene group, a phenylene group, a substituted phenylene group, a five-membered ring or six-membered ring heteroarylene group, a substituted five-membered ring or six-membered ring heteroarylene group or a five-membered ring or six-membered ring heteroarylene group fused with a phenyl ring; and D is a hydrogen atom, a C1-C4-alkyl group, a vinyl group, a C1-C4-alkoxy group, a C1-C4-alkoxycarbonyl group, a bis(C1-C4-alkoxycarbonyl)methyl group, an acetyl(C1-C4-alkoxycarbonyl)methyl group, a cyan group, a carboxy group, an azide group, a hydroxy group, a halogen atom or a rest of the formula CnFmHo, in which n is 1, 2, 3 or 4, m > 1 and m+o = 2n+1.