公开(公告)号：EP3442551A1

公开(公告)日：2019-02-20

申请号：EP17718049.4

申请日：2017-04-12

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Assistance Publique-Hôpitaux de Paris (APHP) ,  Université Paris Diderot - Paris 7 ,  Institut Pasteur ,  Université Paris XIII Paris-Nord

发明人： RICARD, Jean-Damien ,  CLERMONT, Olivier ,  DEBARBIEUX, Laurent ,  DENAMUR, Erick ,  DUFOUR, Nicolas

IPC分类号： A61K35/76 ,  C12N7/00

公开(公告)号：EP3438920A1

公开(公告)日：2019-02-06

申请号：EP17306022.9

申请日：2017-07-31

申请人： Institut Pasteur

发明人： ZIMMER, Christophe ,  OUYANG, Wei

IPC分类号： G06T3/40

摘要： The invention relates to reconstructing a synthetic dense super-resolution image from a sequence of diffraction-limited images acquired by single molecule localization microscopy. After having obtained such a sequence of diffraction-limited images, a sparse localization image is reconstructed from the obtained sequence of diffraction-limited images according to single molecule localization microscopy image processing. The reconstructed sparse localization image is input to an artificial neural network and a synthetic dense super-resolution image is obtained from the artificial neural network, the latter being trained with training data comprising pairs of sparse localization images and corresponding dense super-resolution images, as a function of a training objective function comparing dense super-resolution images and corresponding outputs of the artificial neural network.

公开(公告)号：EP3434690A2

公开(公告)日：2019-01-30

申请号：EP17770648.8

申请日：2017-03-23

申请人： Seoul National University R&DB Foundation ,  Institut Pasteur Korea

发明人： CHUNG, Junho ,  KIM, Ki-Hyun ,  KIM, Hyori ,  OH, Myoung-don ,  PARK, Wan Beom ,  KIM, Seungtaek ,  KIM, Jinhee

IPC分类号： C07K16/10 ,  C07K14/005 ,  G01N33/543 ,  G01N33/569 ,  G01N35/00

摘要： The present invention relates to an antibody which specifically binds to the envelope glycoprotein of severe fever with thrombocytopenia syndrome virus (SFTSV), the pathogen of severe fever with thrombocytopenia syndrome (SFTS), and is used in order to effectively detect or diagnosis SFTSV and treat SFTS.

公开(公告)号：EP3394088A1

公开(公告)日：2018-10-31

申请号：EP16825755.8

申请日：2016-12-22

申请人： Institut Pasteur

发明人： AGOU, Fabrice ,  BOUCHARLAT, Alix ,  COIC, Yves-Marie ,  BALEUX, Françoise

IPC分类号： C07K14/47 ,  A61K38/17 ,  A61P29/00 ,  A61P35/00

摘要： The invention concerns stapled peptide inhibitors of NEMO which inhibit the Nuclear Factor ºB (NF-ºB) signaling pathway and are useful as medicine candidates, in particular as anti-inflammatory or anticancer drugs.

公开(公告)号：EP3359187A1

公开(公告)日：2018-08-15

申请号：EP16788600.1

申请日：2016-10-05

申请人： Merial, Inc. ,  Vetagro-Sup ,  Institut Pasteur

发明人： BOMCHIL, Natalia, Ines ,  CUPILLARD, Lionel, Pierre Christian ,  FONTANA, Célia ,  GUIGAL, Pierre-Michel ,  BOUVET, Jérôme ,  PICARDEAU, Mathieu ,  KODJO, Angeli

IPC分类号： A61K39/02 ,  A61K39/00

CPC分类号： A61K39/0225 ,  A61K2039/522 ,  A61K2039/552 ,  C07K14/20

摘要： The present invention provides compositions or vaccines that contain a recombinant or an attenuated Leptospira interrogans that elicit an immune response in animals against Leptospira infection, including compositions comprising said recombinant or attenuated L. interrogans, methods of vaccination against Leptospira, and kits for use with such methods and compositions.

公开(公告)号：EP3357506A1

公开(公告)日：2018-08-08

申请号：EP17305122.8

申请日：2017-02-02

申请人： Institut Pasteur

发明人： AMINO, Rogerio ,  CHARNEAU, Pierre ,  BEIGNON, Anne-Sophie ,  BLANC, Catherine

IPC分类号： A61K39/015 ,  C07K14/445

CPC分类号： C07K14/445 ,  A61K39/015

摘要： The invention relates to Plasmodium antigenic polypeptides identified through the use of a specifically devised functional immunization screening assay. In particular, the invention relates to antigenic polypeptides of malaria parasites wherein said antigenic polypeptides that exhibit a protective effect, especially that of eliciting a protective immune response in a host against challenge by Plasmodium sporozoites. The invention relates to a combination of compounds, comprising at least 2 distinct active ingredients wherein each active ingredient consists of an antigenic polypeptide of a Plasmodium parasite, a polynucleotide encoding the antigenic polypeptide, or a vector, in particular a viral vector, especially a lentiviral vector, expressing such antigenic polypeptide of a Plasmodium parasite, wherein one antigenic polypeptide is the circumsporozoite protein (CSP) or a polypeptidic derivative thereof and another antigenic polypeptide is either protein Ag40 (11-09) or protein Ag45 (11-10).

公开(公告)号：EP2761011B1

公开(公告)日：2018-05-23

申请号：EP12813090.3

申请日：2012-09-25

申请人： Theravectys ,  Institut Pasteur

发明人： TRAN, Thi-Lan ,  CHARNEAU, Pierre ,  BAUCHE, Cecile

IPC分类号： C12N15/867 ,  C07K14/16

CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N2740/16043 ,  C12N2740/16052 ,  C12N2740/16222 ,  C12N2800/00

摘要： The invention encompasses a lentiviral packaging vector comprising a non-subtype B gag-pol sequence, particularly a subtype D gag-pol sequence. The invention further encompasses methods for making and using these vectors. The invention further encompasses lentiviral vector particles comprising HIV-1 non-subtype B Gag and/or Pol proteins.

公开(公告)号：EP3265586A1

公开(公告)日：2018-01-10

申请号：EP16732333.6

申请日：2016-03-04

申请人： Institut Pasteur ,  Université Paris Diderot - Paris 7

发明人： WEIL, Robert ,  MESSALI, Nassima ,  SOARES, Helena ,  NAOKO, Satoh-Takayama ,  TRIVELLAS, Andromahi ,  DI SANTO, James ,  ALCOVER, Andrés

IPC分类号： C12Q1/68 ,  G01N33/50 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2217/077 ,  A01K2227/105 ,  A01K2267/0387 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/57407 ,  G01N2500/10

摘要： The invention provides methods of identifying an E-SYT2 modulator. The methods may comprise providing a cell that expresses E-SYT2; contacting the cell with a candidate chemical entity; and characterizing recruitment of at least one of Carma1, BcllO, NEMO, and PKC9 to the immunological synapse (IS). The invention also provides E-SYT2 modulators, including inhibitors, identified using the disclosed methods. The invention provides methods of inhibiting NF-κB activity in a cell comprising contacting the cell with an E-SYT2 inhibitor. The invention provides methods comprising providing a sample from a patient suspected of having or at risk of having a MALT-lymphoma or an ABC-DLBCL-lymphoma; and screening the sample to identify the presence and/or absence of a gain of function E-Syt2 mutation in the sample. The invention also provides genetically modified mammals comprising one or two loss of function alleles of E-Syt2.

公开(公告)号：EP1539810B1

公开(公告)日：2017-12-20

申请号：EP03733668.2

申请日：2003-06-19

申请人： INSTITUT PASTEUR ,  MASSEY UNIVERSITY

发明人： Murray, Alan ,  Dupont, Christine

IPC分类号： C07K14/35 ,  A61K39/04 ,  A61P1/00 ,  A61K39/00

CPC分类号： C07K14/35 ,  A61K39/00

摘要： The present invention relates to an immunogenic polypeptide isolated from Mycobacterium avium subspecies paratuberculosis and variants of the polypeptide. The polypeptide and variants may be used in vaccines against Johne's disease and in methods for detection of the disease. Antibodies against the polypeptide or variants may be used in diagnostic tests for Johne's disease. Also included are polynucleotides encoding the polypeptide and variants, and methods for preparing these.

公开(公告)号：EP3250684A1

公开(公告)日：2017-12-06

申请号：EP16701946.2

申请日：2016-01-28

申请人： Institut Pasteur

发明人： VIGNUZZI, Marco ,  BARBEZANGE, Cyril ,  MORATORIO,Gonzalo

IPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2760/00062 ,  C12N2760/16134 ,  C12N2760/16162 ,  C12N2770/00062 ,  C12N2770/24134 ,  C12N2770/24162 ,  C12N2770/32334 ,  C12N2770/32362 ,  Y02A50/383 ,  Y02A50/388

摘要： The application generally relates to the attenuation of a RNA virus or of a clone thereof and involves the alteration of sequence space, more particularly the reduction, of mutational robustness of said RNA virus or clone. The means of the application are more particularly dedicated to the attenuation of an infectious RNA virus or clone, for the production of immunogenic composition or vaccine. More particularly, the means of the application involve the replacement of codon(s) by different codon(s), which is(are) selected to differ by only one nucleotide from a codon STOP, more particularly by different but synonymous codon(s), which is(are) selected to differ by only one nucleotide from a codon STOP.