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163 条记录 (耗时 0.017 秒)

    TREATMENT OF SPASTICITY, CONVULSIONS BY ISOVALERIC ACID DERIVATIVES CNS DEPRESSANTS
    82.
    发明公开
    TREATMENT OF SPASTICITY, CONVULSIONS BY ISOVALERIC ACID DERIVATIVES CNS DEPRESSANTS 失效
    Isovaleramide用于治疗惊风，癫痫，头痛，痉挛

    公开(公告)号：EP0938304A1

    公开(公告)日：1999-09-01

    申请号：EP97941381.0

    申请日：1997-08-29

    申请人： NPS PHARMACEUTICALS, INC.

    发明人： ARTMAN, Linda, D. ,  BALANDRIN, Manuel, F.

    IPC分类号： A61K36 ,  A61K31 ,  A61P25 ,  A61P43

    CPC分类号： A61K31/16 ,  A61K31/19 ,  A61K36/84

    摘要： Preparations and extracts of valerian, as well as isovaleramide, isovaleric acid, and its pharmaceutically acceptable salts, esters, and substituted amides, exhibit clinically significant pharmacological properties which implicate a treatment for a variety of pathological conditions, including spasticity and convulsions, which are ameliorated by effecting a mild depression of CNS activity. The compositions in question generally are non-cytotoxic and do not elicit weakness or sedative activity at doses that are effective for the symptomatic treatment of such pathological conditions.

    Polyamines useful as antagonists of excitatory amino acid neurotransmitters
    88.
    发明公开
    Polyamines useful as antagonists of excitatory amino acid neurotransmitters 失效
    Polyamine verwendbar als Antagonisten von anregbarenAminosäuren-Neurotransmittern。

    公开(公告)号：EP0436332A2

    公开(公告)日：1991-07-10

    申请号：EP90313663.8

    申请日：1990-12-14

    申请人： PFIZER INC. ,  NPS PHARMACEUTICALS, INC.

    发明人： Saccomano, Nicholas Alex ,  Volkmann, Robert Alfred

    IPC分类号： C07D209/18 ,  A61K31/405

    CPC分类号： C07D209/18

    摘要： A substantially pure compound, derived from the venom of Agelenopsis aperta spider, of the formula
    wherein each R is the same and is H or OH.
    The polyamines of this invention and the salts thereof antagonize excitatory amino acid neurotransmitters, which neurotransmitters affect cells of various organisms, and are useful in antagonizing said neurotransmitters, per se, in the treatment of excitatory amino acid neurotransmitter mediated diseases and conditions and in the control of invertebrate pests.

    摘要翻译： 衍生自Agelenopsis aperta蜘蛛的毒液的基本上纯的化合物，其具有式CHEM，其中每个R相同且为H或OH。 本发明的多胺及其盐拮抗兴奋性氨基酸神经递质，其神经递质影响各种生物的细胞，并且可用于拮抗所述神经递质本身在治疗兴奋性氨基酸神经递质介导的疾病和病症以及对照中 的无脊椎动物害虫。