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公开(公告)号：EP2300436B1
公开(公告)日：2018-07-18
申请号：EP09745772.5
申请日：2009-05-14
发明人： PULICI, Maurizio , POLUCCI, Paolo
IPC分类号： C07D231/56 , C07D471/04 , C07D487/04 , C07D497/04 , A61K31/416 , A61K31/4162 , A61P35/00 , A61K31/454 , A61K31/496
CPC分类号： A61K31/496 , A61K31/4162 , A61K31/454 , C07D231/56 , C07D471/04 , C07D487/04 , C07D497/04
摘要： There are provided bicyclic carbonylamino-pyrazoles of formula (I), wherein the variables are as specified in the claims, for use as medicament, in particular for the treatment of diseases due to the malfunctioning of protein kinases (PKs), such as cancer, pharmaceutical compositions comprising such carbamoyl derivatives, and their use as prodrugs of therapeutically active agents. Method of treatment and some new bicyclic carbonylamino-pyrazoles are also object of the present invention.
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公开(公告)号：EP2424868B1
公开(公告)日：2018-01-10
申请号：EP10715240.7
申请日：2010-04-23
IPC分类号： C07D487/04 , A61K31/33 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel crystalline form(s) of water-soluble salts and of free base of a cdk inhibitor. Such crystal salts are for example fumarate, L-malate, maleate, succinate, adipate, malonate, glycolate, phosphate, mesylate, L-lactate, hydrochloride, di-hydrochloride, tri-hydrochloride. Hydrates and polymorphs of such new salt forms, a process for their preparation, their utility in therapy and to the pharmaceutical compositions containing them are also claimed and described in the present application.
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83.发明授权PROCESS FOR THE PREPARATION OF N-[5-(3,5-DIFLUORO-BENZYL)-1H-INDAZOL-3-YL]-4-(4-METHYL-PIPERAZIN-1-YL)-2-(TETRAHYDRO-PYRAN-4-YLAMINO)-BENZAMIDE 无效制备N- [5-（3,5-二氟 - 苄基）-1H-吲唑-3-基] -4-（4-甲基 - 哌嗪-1-基）-2-（四氢吡喃 - -4-基氨基） - 苯甲酰胺
公开(公告)号：EP2855460B1
公开(公告)日：2017-11-08
申请号：EP13724270.7
申请日：2013-05-22
IPC分类号： C07D405/12 , A61K31/496 , A61P35/00
CPC分类号： A61K31/496 , A61P35/00 , C07B2200/13 , C07D405/12 , C07D405/14
摘要： The present invention relates to a process for the preparation of N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide. Novel solid forms of this compound, their utility in treating diseases caused by deregulated protein kinase activity and pharmaceutical compositions containing them are also object of the present invention..
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84.发明授权
公开(公告)号：EP2736514B1
公开(公告)日：2017-10-18
申请号：EP12737280.3
申请日：2012-07-18
发明人： BRASCA, Maria, Gabriella , BERTRAND, Jay, Aaron , GNOCCHI, Paola , MOTTO, Ilaria , NESI, Marcella , PANZERI, Achille , VIANELLO, Paola
IPC分类号： A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , A61P35/00
CPC分类号： A61K31/541 , A61K31/506 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
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85.发明授权1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives 有权1H-吡啶并[3,4-B]吲哚-1-酮和2,3,4,9-四氢-1H-β-咔啉-1-酮衍生物
公开(公告)号：EP2003129B1
公开(公告)日：2017-08-09
申请号：EP08157576.3
申请日：2008-06-04
发明人： Cervi, Giovanni , Felder, Eduard , Papeo, Gianluca Mariano Enrico , Vulpetti, Anna , Gennari, Cesare , La Ferla, Barbara , Nicotra, Francesco , Riccaboni, Mauro
IPC分类号： C07D471/04 , C07D401/04
CPC分类号： C07D471/04
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86.发明授权THERAPEUTIC COMBINATION COMPRISING A CDKs INHIBITOR AND AN ANTINEOPLASTIC AGENT 有权EINEM ANTINEOPLASTISCHEN MITTEL治疗麻醉师EINEM CDKS-INHIBITOR
公开(公告)号：EP2320903B1
公开(公告)日：2017-01-18
申请号：EP09781243.2
申请日：2009-07-29
IPC分类号： A61K31/519 , A61K31/513 , A61K31/7068 , A61K45/06 , A61P35/00
CPC分类号： A61K31/7068 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/519 , A61K31/555 , A61K45/06 , A61K2300/00
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87.发明公开COMPOUNDS FOR TREATING PATIENTS WITH ROS1 MUTANT CANCER CELLS 审中-公开VERBINDUNGEN ZUR BEHANDLUNG VON PATIENTEN MIT MUTANTEN ROS1-KREBSZELLEN
公开(公告)号：EP3107541A1
公开(公告)日：2016-12-28
申请号：EP15705613.6
申请日：2015-02-19
IPC分类号： A61K31/496 , A61P35/04 , A61P35/00
CPC分类号： A61K31/496
摘要： Substituted indazole derivatives of formula (I) or formula 2.(I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）或式（I）的取代的吲唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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公开(公告)号：EP2373626B1
公开(公告)日：2016-08-24
申请号：EP09768400.5
申请日：2009-12-15
发明人： MENICHINCHERI, Maria , BERTRAND, Jay, Aaron , MARCHIONNI, Chiara , NESI, Marcella , ORSINI, Paolo , PANZERI, Achille
IPC分类号： C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , A61K31/416 , A61K31/454 , A61K31/496 , A61P35/00
CPC分类号： C07D405/12 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12
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89.发明授权SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权取代PYRIMIDINYLPYRROLOPYRIDINONDERIVATE，工艺及其使用AS激酶抑制剂和及其
公开(公告)号：EP2443117B1
公开(公告)日：2016-03-23
申请号：EP10725144.9
申请日：2010-06-11
发明人： MARCHIONNI, Chiara , ZUCCOTTO, Fabio , BADARI, Alessandra , ANGIOLINI, Mauro , CARENZI, Davide , CALDARELLI, Marina , PULICI, Maurizio
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , A61N5/00
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90.发明授权DERIVATIVES OF PYRAZOLOPHENYL-BENZENESULFONAMIDE COMPOUNDS AND USE THEREOF AS ANTITUMOR AGENTS 有权PYRAZOLPHENYL - 苯磺酰胺化合物的衍生物及其作为抗肿瘤物质
公开(公告)号：EP2601185B1
公开(公告)日：2015-10-07
申请号：EP11738731.6
申请日：2011-08-02
发明人： PULICI, Maurizio , MARCHIONNI, Chiara , TRAQUANDI, Gabriella , SCOLARO, Alessandra , DONATI, Daniele
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D451/04 , C07D471/04 , A61P35/00 , A61K31/4439
CPC分类号： A61K31/4439 , A61K31/437 , A61K31/4545 , A61K31/506 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D451/04 , C07D471/04
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