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1.发明公开6-AMINO-7-BICYCLO-7-DEAZA-PURINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开作为蛋白激酶抑制剂的6-氨基-7-二环-7-哒嗪 - 嘌呤衍生物
公开(公告)号：EP3218378A1
公开(公告)日：2017-09-20
申请号：EP15793834.1
申请日：2015-11-12
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
摘要： The present invention relates to 6-amino-7-bicyclo-7-deaza-purine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular RET family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions containing these compounds.
摘要翻译： 本发明涉及调节蛋白激酶活性的6-氨基-7-双环-7-脱氮嘌呤衍生物，因此可用于治疗由蛋白激酶活性失调引起的疾病，特别是RET家族激酶。 本发明还提供了制备这些化合物的方法，包含这些化合物的药物组合物以及使用含有这些化合物的药物组合物治疗疾病的方法。
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公开(公告)号：EP2176231A1
公开(公告)日：2010-04-21
申请号：EP08785975.7
申请日：2008-07-08
发明人： LOMBARDI BORGIA, Andrea , MENICHINCHERI, Maria , ORSINI, Paolo , PANZERI, Achille , PERRONE, Ettore , VANOTTI, Ermes , NESI, Marcella , MARCHIONNI, Chiara
IPC分类号： C07D231/56 , A61K31/33 , A61P35/00
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
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公开(公告)号：EP2917214B1
公开(公告)日：2019-08-28
申请号：EP13783956.9
申请日：2013-10-31
发明人： MENICHINCHERI, Maria , ANGIOLINI, Mauro , BERTRAND, Jay Aaron , CARUSO, Michele , POLUCCI, Paolo , QUARTIERI, Francesca , SALOM, Barbara , SALSA, Matteo , ZUCCOTTO, Fabio
IPC分类号： A61K31/496 , A61K45/06 , A61N5/10 , A61K31/506 , C07D471/04
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4.发明授权PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权吡咯并[2,3-D]嘧啶衍生物，其制备方法及其作为激酶抑制剂的用途
公开(公告)号：EP2997030B1
公开(公告)日：2017-08-09
申请号：EP14721891.1
申请日：2014-05-07
发明人： ANGIOLINI, Mauro , BUFFA, Laura , MENICHINCHERI, Maria , MOTTO, Ilaria , POLUCCI, Paolo , TRAQUANDI, Gabriella , ZUCCOTTO, Fabio
IPC分类号： C07D487/04
CPC分类号： A61K31/519 , A61K31/496 , A61K45/06 , C07D487/04
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公开(公告)号：EP4217354A1
公开(公告)日：2023-08-02
申请号：EP21773829.3
申请日：2021-09-15
发明人： BINDI, Simona , BUFFA, Laura , CERVI, Giovanni , D ALESSIO, Roberto , MENICHINCHERI, Maria , MODUGNO, Michele
IPC分类号： C07D403/04 , C07D403/14 , A61P35/00 , A61K31/415 , A61K31/506
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6.发明授权
公开(公告)号：EP2176231B1
公开(公告)日：2016-10-19
申请号：EP08785975.7
申请日：2008-07-08
发明人： LOMBARDI BORGIA, Andrea , MENICHINCHERI, Maria , ORSINI, Paolo , PANZERI, Achille , PERRONE, Ettore , VANOTTI, Ermes , NESI, Marcella , MARCHIONNI, Chiara
IPC分类号： C07D231/56 , A61K31/33 , A61P35/00
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
摘要翻译： 式（I）的取代的吲唑衍生物及其药学上可接受的盐，如说明书中所定义; 本发明的化合物可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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公开(公告)号：EP2120933B1
公开(公告)日：2015-07-08
申请号：EP08709082.5
申请日：2008-02-18
IPC分类号： C07D471/14 , A61P35/00
CPC分类号： C07D471/04 , C07D471/14
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公开(公告)号：EP2120933A1
公开(公告)日：2009-11-25
申请号：EP08709082.5
申请日：2008-02-18
IPC分类号： A61K31/437
CPC分类号： C07D471/04 , C07D471/14
摘要： Heteroarylpyridinone derivatives represented by formula (I) wherein R1, R2, R3, R4, R5, and X are as defined in the specification, compositions thereof, and methods of use thereof. Particularly, there are described isoquinolinoyrrolopyridinones, pharmaceutical compositions comprising them and their use as therapeutic agents in the treatment of cancer and cell proliferation disorders.
摘要翻译： 由式（I）表示的杂芳基吡啶酮衍生物，其中R1，R2，R3，R4，R5和X如说明书中所定义，其组合物及其使用方法。 特别地，描述了异喹啉并吡咯并吡啶酮，包含它们的药物组合物以及它们在治疗癌症和细胞增殖疾病中作为治疗剂的用途。
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9.发明公开
公开(公告)号：EP4313971A1
公开(公告)日：2024-02-07
申请号：EP22716947.1
申请日：2022-03-22
IPC分类号： C07D403/04 , C07D417/04 , C07D471/04 , A61P35/00 , A61K31/4155 , A61K31/427 , A61K31/437 , A61K31/506
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公开(公告)号：EP3218378B1
公开(公告)日：2020-01-08
申请号：EP15793834.1
申请日：2015-11-12
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
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